博彩公司排名-博彩公司评级 副教授,硕士生导师。2002年毕业于中山大学,获理学学士学位;2009毕业于中国科学院上海生命科学研究院,获理学博士学位;2009年至2012年在美国University of Pennsylvania进行博士后研究工作;2013年获中山大学“百人计划”引进人才,被聘为博彩公司排名 副教授。

    主要致力于非编码RNA在干细胞的维持、诱导分化和重编程中的作用机理,以及非编码RNA在肿瘤生物学中的功能研究。作为课题负责人承担国家重点研发计划1项,国家自然科学基金1项,广东省科技计划1项。共发表相关领域研究文章及综述10余篇。

 

已发表论文:

1: Lin X, Yang F, Qi X, Li Q, Wang D, Yi T, Yin R, Zhao X, Zhong X*, Bian C*. LncRNA DANCR promotes tumor growth and angiogenesis in ovarian cancer through direct targeting of miR-145. Mol Carcinog. 2019;58:2286–2296. (*Corresponding authors)

2: Zhang L, Peng D, Sood AK, Dang CV, Zhong X*. Shedding Light on the Dark Cancer Genomes: Long Noncoding RNAs as Novel Biomarkers and Potential Therapeutic Targets for Cancer. Mol Cancer Ther. 2018 Sep;17(9):1816-1823. Review. (*Corresponding author)

3: Lin X, Shen J, Peng D, He X, Xu C, Chen X, Tanyi JL, Montone K, Fan Y, Huang Q, Zhang L, Zhong X*. RNA-binding protein LIN28B inhibits apoptosis through regulation of the AKT2/FOXO3A/BIM axis in ovarian cancer cells. Signal Transduct Target Ther. 2018 Aug 31;3:23. (*Corresponding author)

4: Zhong X*, Zhang D, Xiong M, Zhang L. Noncoding RNA for Cancer Gene Therapy. Recent Results Cancer Res. 2016;209:51-60. (*Corresponding author)

5: Zhong X*, Zheng L, Shen J, Zhang D, Xiong M, Zhang Y, He X, Tanyi JL, Yang F, Montone KT, Chen X, Xu C, Xiang AP, Huang Q, Xu X, Zhang L*. Suppression of MicroRNA 200 Family Expression by Oncogenic KRAS Activation Promotes Cell Survival and Epithelial-Mesenchymal Transition in KRAS-Driven Cancer. Mol Cell Biol. 2016 Oct 13;36(21):2742-2754.  (*Corresponding authors)

6: Zhang D, Xiong M, Xu C, Xiang P, Zhong X*. Long Noncoding RNAs: An Overview. Methods Mol Biol. 2016;1402:287-95. (*Corresponding author)

7: Zhong X*, Hu X, Zhang L. Oncogenic long noncoding RNA FAL1 in human cancer. Mol Cell Oncol. 2015 Feb 25;2(2):e977154. (*Corresponding author)

8: Yang X#, Zhong X#, Tanyi JL, Shen J, Xu C, Gao P, Zheng TM, Demichele AM, Zhang L. mir-30d regulates multiple genes in the autophagy pathway and impairs autophagy process in human cancer cells. Biochem Biophys Res Commun. 2013 Feb 15;431(3):617-22. (#Co-first author)

9: Zhong X, Coukos G, Zhang L. miRNAs in human cancer. Methods Mol Biol. 2012;822:295-306.

10: Zhong X, Li N, Liang S, Huang Q, Coukos G, Zhang L. Identification of microRNAs regulating reprogramming factor LIN28 in embryonic stem cells and cancer cells. J Biol Chem. 2010 Dec 31;285(53):41961-71.

11: Zhong X, Jin Y. Critical roles of coactivator p300 in mouse embryonic stem cell differentiation and Nanog expression. J Biol Chem. 2009 Apr 3;284(14):9168-75.

12: Yuan J, Hu Z, Mahal BA, Zhao SD, Kensler KH, Pi J, Hu X, Zhang Y, Wang Y, Jiang J, Li C, Zhong X, Montone KT, Guan G, Tanyi JL, Fan Y, Xu X, Morgan MA, Long M, Zhang Y, Zhang R, Sood AK, Rebbeck TR, Dang CV, Zhang L. Integrated Analysis of Genetic Ancestry and Genomic Alterations across Cancers. Cancer Cell 2018 Oct 8;34, 549–560.

13: Zhang D, Zhang G, Hu X, Wu L, Feng Y, He S, Zhang Y, Hu Z, Yang L, Tian T, Xu W, Wei Z, Lu Y, Flaherty KT, Zhong X, Mills GB, Gimotty PA, Xu X, Herlyn M, Zhang L. Oncogenic RAS Regulates Long Noncoding RNA Orilnc1 in Human Cancer. Cancer Res. 2017 Jul 15;77(14):3745-3757.

14: Hu X, Feng Y, Zhang D, Zhao SD, Hu Z, Greshock J, Zhang Y, Yang L, Zhong X, Wang LP, Jean S, Li C, Huang Q, Katsaros D, Montone KT, Tanyi JL, Lu Y, Boyd J, Nathanson KL, Li H, Mills GB, Zhang L. A Functional Genomic Approach Identifies FAL1 as an Oncogenic Long Noncoding RNA that Associates with BMI1 and Represses p21 Expression in Cancer. Cancer Cell. 2014 Sep 8;26(3):344-57.

15: Liao B, Zhong X, Xu H, Xiao F, Fang Z, Gu J, Chen Y, Zhao Y, Jin Y. Itch, an E3 Ligase of Oct4, Is Required for Embryonic Stem Cell Self-Renewal and Pluripotency Induction. J Cell Physiol.  2013 Jul;228(7):1443-51.

16: Li N, Zhong X, Lin X, Guo J, Zou L, Tanyi JL, Shao Z, Liang S, Wang LP, Hwang WT, Katsaros D, Montone K, Zhao X, Zhang L. lin-28 homologue A (LIN28A) promotes cell cycle progression via the regulation of cyclin-dependent kinase 2 (CDK2), cyclin D1 (CCND1), and cell division cycle 25 homolog A (CDC25A) expression in cancer. J Biol Chem. 2012 May 18;287(21):17386-97.

17: Li N, Kaur S, Greshock J, Lassus H, Zhong X, Wang Y, Leminen A, Shao Z, Hu X, Liang S, Katsaros D, Huang Q, Bützow R, Weber BL, Coukos G, Zhang L. A combined array-based comparative genomic hybridization and functional library screening approach identifies mir-30d as an oncomir in cancer. Cancer Res. 2012 Jan 1;72(1):154-64.

18: Yang X, Lin X, Zhong X, Kaur S, Li N, Liang S, Lassus H, Wang L, Katsaros D, Montone K, Zhao X, Zhang Y, Bützow R, Coukos G, Zhang L. Double-negative feedback loop between reprogramming factor LIN28 and microRNA let-7 regulates aldehyde dehydrogenase 1-positive cancer stem cells. Cancer Res. 2010 Nov 15;70(22):9463-72.