博彩公司排名

   博彩公司排名-博彩公司评级 教授，博士生导师。2002 年 6 月毕业于北京师范大学， 获理学学士学位。之后于 2005 年 6 月毕业于中国协和医科大学获医学硕士学位。2009 年 6 月毕业 于北京生命科学研究所，获理学博士学位。后于 2009 年 9 月开始在美国西奈山医学院（Icahn School of Medicine at Mount Sinai, NY, U.S.A.）进行博士后研究至 2015 年底。2015 年获聘中 山大学“百人计划”引进人才，并于 2016 年入选中组部“青年千人计划”引进回国，在中山大学 任职至今。 
   基于表观调控机理，提高多能干细胞质与量，促进其临床转化。主要成绩：⑴首次发现 TET1 和 TET2 从 DNA 去甲基化的表观层面提高 iPS 细胞诱导效率和质量并阐释其机理(Nature,2013)；⑵ 进一步发现新型多能因子 TEX10 可通过超级增强子的表观修饰，促进干细胞多能性(Cell Stem Cell,2015)；⑶在此基础上发现超级增强子的表观修饰可被 YY1 与染色质重塑复合物 BAF 协同调 控，活化多能性基因表达（Stem Cell Reports,2018）；⑷为以上表观研究建立蛋白组学方法 (Cell Research,2012)。这些研究为提高多能干细胞质与量提供全新表观途径，为其临床转化提供 理论基础。近年共发表 SCI 论著 21 篇，引用超 1300 次，其中以通讯或（共同）一作发表论著 7 篇 （3 篇 IF>15）。 
   本课题组通过深入研究干细胞的多能性以及体细胞重编程的分子机理，阐明胚胎干细胞的自我 更新、分化及体细胞重编程的发生发展过程，并利用 iPS 细胞建立肿瘤疾病模型，对于干细胞的临 床应用具有重要意义。基于此，实验室正在开展以下几个方面研究： 
1、利用蛋白质组学、基因编辑等手段研究多能干细胞维持及分化、体细胞重编程及早期胚胎发 育的表观遗传调控机制； 2、结合相分离和染色体三维结构技术（HiC、HiChIP 等）研究干细胞多能性的表观机制； 3、利用生物信息学技术进行表观组学研究，整合二维的基因组学、转录组学、蛋白组学等数据 和 HiC、HiChIP 等染色质三维数据，进行细胞命运和疾病发生的研究； 4、利用诱导多能干细胞（iPS 细胞）建立人类疾病模型，特别是乳腺癌模型，并利用模型研究 其发病机理，长期目标为筛选药物。 

 
发表论文： 
 
1. Fuxi Li, Yang Yi, Yanyan Miao, Wenyong Long, Teng Long, Siyun Chen, Weisheng Cheng, Changye Zou, Yueyuan Zheng, Xingui Wu, Junjun Ding, Kaiyu Zhu, Delin Chen, Qiongcong Xu, Jinkai Wang, Qing Liu, Feng Zhi, Jian Ren, Qi Cao and Wei Zhao. N6-Methyladenosine Modulates Nonsense-Mediated mRNA Decay in Human Glioblastoma. Cancer Research. 2019 Nov 15;79(22):5785-5798. （IF: 8.378） 
 
2. Xiaona Huang* Chao Wei* Fenjie Li* Lumeng Jia, Pengguihang Zeng, Jiahe Li, Jin Tan, Tuanfeng Sun, Shaoshuai Jiang, Jia Wang, Xiuxiao Tang, Qingquan Zhao, Bin Liu, Limin Rong, Cheng Li, and Junjun Ding# (Corresponding author). PCGF6 regulates stem cell pluripotency as a transcription activator via super-enhancer dependent chromatin interactions. Protein Cell. 2019 Oct;10(10):709-725. （IF: 7.575） 
 
3. Li Fenjie, Junjun Ding# (Corresponding author).  Sialylation is involved in cell fate decision during development, reprogramming and cancer progression. Protein Cell. 2019 Aug;10(8):550-565. Review. （IF: 7.575） 
 
4. Kun-Yong Kim, Yoshiaki Tanaka, Juan Su, Bilal Cakir, Yangfei Xiang, Benjamin Patterson, Junjun Ding, Yong-Wook Jung, Ji-Hyun Kim, Eriona Hysolli, Haelim Lee, Rana Dajani, Jonghwan Kim, Mei Zhong, Jeong-Heon Lee, David Skalnik, Jeong Mook Lim, Gareth J. Sullivan, Jianlong Wang & In-Hyun Park. Uhrf1 regulates active transcriptional marks at bivalent domains in pluripotent stem cells through Setd1a, Nature Communicaitons. 2018 Jul 3;9(1):2583. doi: 10.1038/s41467-018-04818-0. （IF: 11.878） 
 
5. Songyan Han, Christopher Tan, Junjun Ding, Jianlong Wang, Avi Ma'ayan, Valerie Gouon-Evans. Endothelial cells instruct liver specification of embryonic stem cell-derived endoderm through endothelial VEGFR2 signaling and endoderm epigenetic modifications, Stem Cell Research. 2018 Jul;30:163-170. doi: 10.1016/j.scr.2018.06.004. （IF: 3.929） 
 
6. Jia Wang*, Xingui Wu*, Chao Wei*, Xin Huang, Qian Ma, Xiaona Huang, Francesco Faiola, Diana Guallar, Miguel Fidalgo, Tingyuan Huang, Di Peng, Li Chen, Haopeng Yu, Xingyu Li, Junyi Sun, Xinyi Liu, Xiaoxia Cai, Xiao Chen, Ling Wang, Jian Ren, Jianlong Wang#, Junjun Ding# (Corresponding author). YY1 Positively Regulates Transcription by Targeting Promoters and Super-Enhancers through the BAF Complex in Embryonic Stem Cells, Stem Cell Reports. 2018 March 1; doi: 10.1016/j.stemcr.2018.02.004. （IF: 5.499） 
 
7. Diana Guallar, Xianju Bi, Jose Angel Pardavila, Xin Huang, Carmen Saenz, Xianle Shi, Hongwei Zhou, Francesco Faiola, Junjun Ding, Phensinee Haruehanroengra, Fan Yang, Dan Li, Carlos Sanchez-Priego, Arven Saunders, Feng Pan, Victor Julian Valdes, Kevin Kelley, Miguel G. Blanco, Lingyi Chen, Huayan Wang, Jia Sheng, Mingjiang Xu, Miguel Fidalgo, Xiaohua Shen & Jianlong Wang. RNA-dependent chromatin targeting of TET2 for endogenous retrovirus control in pluripotent stem cells, Nature Genetic. 2018 Feb 26. doi: 10.1038/s41588-018-0060-9. （IF: 25.455） 
 
8. Chunliu Huang  Junjie Shi  Yibin Guo  Weijun Huang  Shanshan Huang Siqi Ming  Xingui Wu  Rui Zhang  Junjun Ding  Wei Zhao  Jie Jia  Xi Huang Andy Peng Xiang  Yongsheng Shi  Chengguo Yao. A snoRNA modulates mRNA 3' end processing and regulates the expression of a subset of mRNAs, Nucleic Acids Res earch . 2017 Sep 6;45(15):8647-8660.  （IF: 11.147） 
 
9. Francesco Faiola, Nuoya Yin, Miguel Fidalgo, Xin Huang, Arven Saunders, Junjun Ding, DianaGuallar, BaoyenDang, JianlongWang. NAC1 Regulates Somatic Cell Reprogramming by Controlling Zeb1 and E-cadherin Expression, Stem Cell Reports. 2017 Sep 12;9(3):913-926. （IF: 7.338） 
 
10. Arven Saunders, Dan Li, Francesco Faiola, Xin Huang, Miguel Fidalgo, Diana Guallar, Junjun Ding, Fan Yang, Yang Xu, Hongwei Zhou, Jianlong Wang. Context-Dependent Functions of NANOG Phosphorylation in Pluripotency and Reprogramming, Stem Cell Reports. 2017 May 9;8(5):1115-1123. （IF: 7.338） 
 
11. Bo Yang, Yi Qiu, Niu Zhou, Hong Ouyang, Junjun Ding, Bin Cheng, Jianbo Sun. Application of Stem Cells in Oral Disease Therapy: Progresses and Perspectives. Frontiers in Physiology. 2017 Apr 3;8:197. Review. （IF: 4.134）  
 
12. Arven Saunders, Xin Huang, Miguel Fidalgo, Michael H. Reimer Jr., Francesco Faiola, Junjun Ding, Carlos SánchezPriego, Diana Guallar, Carmen Sáenz, Dan Li, Jianlong Wang. The SIN3A/HDAC Corepressor Complex Functionally Cooperates with NANOG to Promote Pluripotency, Cell Reports. 2017 Feb 14;18(7):1713-1726. （IF: 8.282） 
 
13. Miguel Fidalgo, Xin Huang, Diana Guallar, Carlos Sanchez-Priego, Victor Julian Valdes, Arven Saunders, Junjun Ding, Wen-Shu Wu, Carlos Clave, Jianlong Wang. Zfp281 Coordinates Opposing Functions of Tet1 and Tet2 in Pluripotent States, Cell Stem Cell. 2016 Jun 21. （IF: 23.394） 
 
14. Jiao Yang, Renpeng Guo, Hua Wang, Xiaoying Ye, Zhongcheng Zhou, Jiameng Dan, Haiying Wang, Peng Gong, Wei Deng, Yu Yin, ShiQing Mao, Lingbo Wang, Junjun Ding, Jinsong Li, David L. Keefe, Meelad M. Dawlaty, Jianlong Wang, GuoLiang Xu, Lin Liu. Tet Enzymes Regulate Telomere Maintenance and Chromosomal Stability of Mouse ESCs, Cell Reports. 2016 May 24;15(8):1809-21. （IF: 7.87） 
 
15. Junjun Ding, Xin Huang, Ningyi Shao, Hongwei Zhou, Dung-Fang Lee, Francesco Faiola, Miguel Fidalgo, Diana Guallar, Arven Saunders, Pavel V. Shliaha, Hailong Wang, Avinash Waghray, Dmitri Papatsenko, Carlos Sánchez-Priego, Dan Li, Ye Yuan, Ihor R. Lemischka, Li Shen, Kevin Kelley, Haiteng Deng, Xiaohua Shen, and Jianlong Wang. Tex10 Coordinates Epigenetic Control of Super-Enhancer Activity in Pluripotency and Reprogramming, Cell Stem Cell. 2015 Jun 4;16(6):65368. （IF: 23.394） 
 
16. Yael Costa*, Junjun Ding* (co-first author), Thorold W. Theunissen*, Francesco Faiola*, Timothy A. Hore, Pavel V. Shliaha, Miguel Fidalgo, Arven Saunders, Moyra Lawrence, Sabine Dietmann, Satyabrata Das, Dana N. Levasseur, Zhe Li, Mingjiang Xu, Wolf Reik, Jose´ C. R. Silva & Jianlong Wang.  NANOG-dependent function of TET1 and TET2 in establishment of pluripotency, Nature. 2013 Mar 21;495(7441):370-4. （IF: 40.137） 
 
17. Miguel Fidalgo, Francesco Faiola, Carlos-Filipe Pereira, Junjun Ding, Arven Saunders, Julian Gingold, Christoph Schaniel, Ihor R. Lemischka, José C. R. Silva, and Jianlong Wang. Zfp281 mediates Nanog   autorepression through recruitment of the NuRD complex and inhibits somatic cell reprogramming, Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):16202-7. （IF: 9.661） 
 
18. Junjun Ding, Huilei Xu, Francesco Faiola, Avi Ma'ayan, Jianlong Wang. Oct4 links multiple epigenetic pathways to the pluripotency network, Cell Research. 2012 Jan;22(1):155-67（IF: 17.848） 
 
19. Yen-Sin Ang, Su-Yi Tsai, Dung-Fang Lee, Jonathan Monk, Jie Su, Kajan Ratnakumar, Junjun Ding, Yongchao Ge, Henia Darr, Betty Chang, Jianlong Wang, Michael Rendl, Emily Bernstein, Christoph Schaniel and Ihor R. Lemischkar. Wdr5 Mediates Self-Renewal and Reprogramming via the Embryonic Stem Cell Core Transcriptional Network, Cell. 2011, Volume 145, Issue 2, 15 April 2011, Pages 183-197. （IF: 30.410） 
 
20. Gang Chang, Yi-Liang Miao, Yu Zhang, Sheng Liu, Zhaohui Kou, Junjun Ding, Da-Yuan Chen, Qing-Yuan Sun, Shaorong Gao. Linking incomplete reprogramming to the improved pluripotency of murine embryonal carcinoma cellderived pluripotent stem cells, PLoS One. 2010 Apr 26;5(4):e10320. （IF: 2.806） 
 
21. Junjun Ding*, Yuanbiao Guo*, Sheng Liu, Yujuan Yan, Gang Chang, Zhaohui Kou, Yu Zhang, Ying Jiang, Fuchu He, Shaorong Gao and Jianli Sang. ES Cells Derived from Somatic Cloned and Fertilized Blastocysts are Post- transcriptionally Indistinguishable: a MicroRNA and Protein Profiles Comparison, Proteomics. 2009 May; 9(10):2711-21. （IF: 4.041） 
 
22. Ding Jun-Jun*, Guo Chen-Ying*, Cai Qi-Liang, Lin Ya-Hui, Wang Heng. In vivo expression of green fluorescent protein gene and immunogenicity of ES312 vaccine both mediated by starburst polyamidoamine dendrimers, Acta Academiae Medicinae Sinicae, 2005 March; Vol.27 (4): 499-503