中山大学博士后,2020年获中山大学外科学博士学位。主要从事睾丸的发育与衰老相关研究;利用食蟹猴动物模型,初步证实睾丸间质干细胞(stem Leydig cells,SLCs)移植治疗雄激素低下性疾病的安全性及有效性,并发现了人SLCs的新标志物—endosialin,对促进SLCs疗法的临床转化具有重要意义。在Theranostics,Human Reproduction,Cell Discovery等杂志发表论文6篇。
发表文章:
(1) Kai Xia#, Hong Chen#, Jiancheng Wang#, Xin Feng#, Yong Gao, Yi Wang, Rongda Deng, Chunxing Wu, Peng Luo, Min Zhang, Chao Wang, Yong Zhang, Yadong Zhang, Guihua Liu, Xiang’an Tu, Xiangzhou Sun, Weiqiang Li, Qiong Ke*, Chunhua Deng*, Andy Peng Xiang*. Restorative functions of autologous stem Leydig cell transplantation in a testosterone-deficient non-human primate model. Theranostics. 2020;10(19):8705-8720.
(2) Kai Xia, Yuanchen Ma, Xin Feng, Rongda Deng, Qiong Ke, Andy Peng Xiang*. Chunhua Deng*. Endosialin defines human stem Leydig cells with regenerative potential. Hum Reprod. 2020;35(10):2197-2212.
(3) Hong Chen#, Kai Xia#, Weijun Huang#, Huijian Li, Chao Wang, Yuanchen Ma, Peng Luo, Shuwei Zheng, Yi Wang, Lin Dong, Zhipeng Tan, Xingqiang Lai, Fuxiang Mao, Weiqiang Li, Xiaoyan Liang, Tao Wang, Andy Peng Xiang, Qiong Ke*. Autologous transplantation of thecal stem cells restores ovarian function in nonhuman primates. Cell Discovery. 2021; In Press.
(4) Xin Feng#, Kai Xia#, Qiong Ke#, Rongda Deng, Jintao Zhuang, Zi Wan, Peng Luo, Fulin Wang, Zhijun Zang, Xiangzhou Sun, Andy Peng Xiang, Xiang'an Tu*, Yong Gao*, Chunhua Deng*. Transplantation of encapsulated human Leydig-like cells: A novel option for the treatment of testosterone deficiency. Mol Cell Endocrinol. 2020;519:111039.
(5) Chi Zhang#, Yun Xie#, Haicheng Chen#, Linyan Lv, Jiahui Yao, Min Zhang, Kai Xia, Xin Feng, Yanqing Li, Xiaoyan Liang, Xiangzhou Sun, Chunhua Deng*, Guihua Liu*. FOXO4-DRI alleviates age-related testosterone secretion insufficiency by targeting senescent Leydig cells in aged mice. Aging. 2020;12:1272-1284.
(6) Min Zhang#, Jiancheng Wang#, Chunhua Deng#, Meihua Jiang, Xin Feng, Kai Xia, Weiqiang Li, Xingqiang Lai, Haipeng Xiao, Renshan Ge, Yong Gao*, Andy Peng Xiang*. Transplanted human p75-positive stem Leydig cells replace disrupted Leydig cells for testosterone production. Cell Death & Disease. 2017;8(10):e3123.