中山大学博士后,2018年获博彩公司排名-博彩公司评级 博士学位。主要从事干细胞与基因编辑治疗研究;参与建立了多种人类遗传疾病iPSC细胞模型以及MCPH1,Shank3和FAH等基因缺陷食蟹猴模型,对阐明神经系统和遗传代谢相关疾病具有重要意义。在Cell Research, Stem Cell Research, Stem Cell Reports, Neuroreport等发表SCI论文多篇。主持国自然青年科学基金、中国博士后科学基金各1项。

 

承担的科研项目:

1,国家自然科学基金委员会,青年科学基金项目,81901514,酪氨酸血症Ⅰ型的体外疾病模型建立及基因修复治疗的实验研究,2020-01-2022-12,项目负责人

2,中国博士后科学基金会,面上二等,2019M663280,不同分化起源MSCs治疗下肢缺血疾病的作用及机制研究,2020-01至2021-12,项目负责人

参与发表的文章:

(1) Lai X#, Jiang B#, Liu J, Wang Y*, Wu G*. Generation of an induced pluripotent stem cell line (SYSUi002-A) from a patient with coronary slow flow phenomenon. Stem Cell Res. 2019 Dec; 41: 101646.(3.929)

(2) Ke Q#, Li W#, Lai X#, Chen H, Huang L, Kang Z, Li K, Ren J, Lin X, Zheng H, Huang W, Ma Y, Xu D, Ch Z, Song X, Lin X, Zh M, Wang T, Zh F, Xi J, Mao F, Xia H, Lahn BT,Zhou Q*, Yang S*, Xiang AP*. TALEN-based generation of a cynomolgus monkey disease model for human microcephaly. Cell Research. 2016 Sep; 26(9): 1048-61.  (IF:15.606)

(3) Wang Y#, Lai X#, Huang L#, Liu G, Zai Z, Zhu D, Zhang Y, Liang Z, Yao Z, Chen Y, Wen Z*, Xia H*. Establishment of an induced pluripotent stem cell model of Hirschsprung disease from a patient carrying a novel RET mutation. NeuroReport. 2018 Aug; 29(12): 975-980. (IF:1.266)

(4) Zhou Y#, Sharma J#, Ke Q#, Landman R#, Yuan J, Chen H, Hayden DS, Fisher JW 3rd, Jiang M, Menegas W, Aida T, Yan T, Zou Y, Xu D, Parmar S, Hyman JB, Fanucci-Kiss A, Meisner O, Wang D, Huang Y, Li Y, Bai Y, Ji W, Lai X, Li W, Huang L, Lu Z, Wang L, Anteraper SA, Sur M, Zhou H*, Xiang AP*, Desimone R, Feng G*, Yang S*. Atypical behaviour and connectivity in SHANK3-mutant macaques. Nature. 2019 Jun;570(7761):326-331.

(5) Feng Y#, Liao Y#, Huang W#, Lai X, Luo J, Du C, Lin J, Zhang Z, Qiu D, Liu Q, Shen H, Xiang AP*, Zhang Q*. Mesenchymal stromal cells-derived matrix Gla protein contribute to the alleviation of experimental colitis. Cell Death Dis. 2018 Jun; 9(6): 691.

(6)Ke Q#, Li L#, Yao X#, Lai X, Cai B, Chen H, Chen R, Zhai Z, Huang L, Li K, Hu A, Mao FF, Xiang AP, Tao L*, Li W*. Enhanced generation of human induced pluripotent stem cells by ectopic expression of Connexin 45. Sci Rep. 2017. Mar 28;7(1): p. 458. (IF:4.259)

(7) Li W#, Huang L#, Lin W#, Ke Q, Chen R, Lai X, Wang X, Zhang J, Jiang M, Huang W, Wang T, Yang X, Chen Y, Song W*, Xiang AP*. Engraftable neural crest stem cells derived from cynomolgus monkey embryonic stem cells. Biomaterials. 2015 Jan;39:75-84. (IF:8.402)