男，77年7月生。中山大学干细胞与组织工程中心研室副教授，博士生导师。
长期从事遗传性疾病的研究，工作侧重于发病机制的探讨。现工作重点转入MSCs生物学特性及相关分子机制的研究，和改造细胞、优化MSCs治疗效能的研究，目前研究已取得以下成果：
①在MSCs生物学特性方面：证实骨髓MSCs在生物特性及基因表达上存在异质性（Int J Biochem Cell Biol 45: 2431-2443, 2013）；在肾脏中分离的Nestin 阳性细胞具有自我更新和间质分化能力，证明Nestin是成体组织MSCs的特异标志，为进一步获得适合损伤修复的MSCs亚群提供了重要依据（Biomaterials 50:56-66, 2015）；证实MSCs能够增强CD8+CD28-调节性T细胞的免疫调节能力，丰富了MSCs免疫调节作用的细胞学机制（Cell Mol Immunol 12:708-718, 2015）。
②在MSCs生物学特性相关分子机制方面：证实IL-8是介导MSCs促血管生成的重要分子，参与了MSCs对结直肠癌细胞生长的影响（Oncotarget 6:42825-42837, 2015）；证实IGFBP7是新的免疫调节分子，是介导MSCs免疫调节的重要分子，MSCs通过IGFBP7能有效舒缓炎性肠病（Inflammatory Bowel Disease）小鼠模型的临床症状（Mol Ther 24:1860-1872, 2016）；证实GBP1是介导MSCs抵御弓形虫的重要分子，参与宿主防御（Host Defense），抵抗微生物入侵（Proc Natl Acad Sci U S A 114:1365-1370,2017 ）。
③在改造细胞、优化MSCs治疗效能方面：证实过表达CXCR5的MSCs能更多到达病灶，更好治疗迟发性超敏反应（Delayed Type Hypersensitivity）（Mol Ther 25: 1434-1447, 2017）；成功将食蟹猴胚胎干细胞诱导为神经嵴干细胞（Neural Crest Stem Cells）（Biomaterials 39:75-84, 2015.）；成功建立人小脑畸形的食蟹猴模型（Cell Res 26:1048-1061, 2016）。目前已发表相关SCI文章25篇，其中第一或通讯作者7篇。
承担科研项目情况：
1. 基于恶性婴儿型石骨症诱导多能干细胞模型的破骨细胞功能缺陷机制及基因修复的研究；31371482；75万；国家自然科学基金；黄玮俊（负责人），赖文玉，柯琼，蔡炳，陈霏，颜孙兴，陈小湧，刘秋莉，周立文，王涛；2014.01-2017.12；实验设计及统筹实施。
2. 白癜风和Graves 病分子诊断试剂盒的研发；2010J-E191；15万元；广州市科技计划项目；黄玮俊（负责人），邓伟平，黄知敏，袁萍，郑灵燕，房玮，钟良英，张永玲，胡彬；2010.06-2013.07；实验设计及统筹实施。
3. 一个白癜风合并Graves病家系致病基因/基因组变异的定位及鉴定；20100171120055；3.6万元；高等学校博士学科点专项科研基金；黄玮俊（负责人），邓伟平，黄知敏，袁萍，郑灵燕，房玮，钟良英，张永玲，胡彬；2011.01-2013.12；实验设计及统筹实施。
代表性论著：
1. Zhang X, Huang W, Chen X, Lian Y, Wang J, Cai C, Huang L, Wang T, Ren J, Xiang AP. CXCR5-Overexpressing Mesenchymal Stromal Cells Exhibit Enhanced Homing and Can Decrease Contact Hypersensitivity. Mol Ther. 2017.25(6):1434-1447. (共同第一作者, IF:6.938)
2. Qin A, Lai DH, Liu Q, Huang W, Wu YP, Chen X, Yan S, Xia H, Hide G, Lun ZR, Ayala FJ, Xiang AP. Guanylate-binding protein 1 (GBP1) contributes to the immunity of human mesenchymal stromal cells against Toxoplasma gondii. Proc Natl Acad Sci U S A. 2017.114(6):1365-1370. (共同第一作者, IF:9.423)
3. Liao Y, Lei J, Liu M, Lin W, Hong D, Tuo Y, Jiang MH, Xia H, Wang M, Huang W, Xiang AP. Mesenchymal Stromal Cells Mitigate Experimental Colitis via Insulin-like Growth Factor Binding Protein 7-mediated Immunosuppression. Mol Ther. 2016.24.(10):1860-1872. (共同通讯作者, IF:6.938)
4. Ke Q, Li W, Lai X, Chen H, Huang L, Kang Z, Li K, Ren J, Lin X, Zheng H, Huang W, Ma Y, Xu D, Chen Z, Song X, Lin X, Zhuang M, Wang T, Zhuang F, Xi J, Mao FF, Xia H, Lahn BT, Zhou Q, Yang S, Xiang AP. TALEN-based generation of a cynomolgus monkey disease model for human microcephaly. Cell Res. 2016.26.(9):1048-61. (IF:14.812)
5. Liu Q, Zheng H, Chen X, Peng Y, Huang W, Li X, Li G, Xia W, Sun Q, Xiang AP.Human mesenchymal stromal cells enhance the immunomodulatory function of CD8(+)CD28(-) regulatory T cells. Cell Mol Immunol. 2015.12.(6):708-18. (IF:5.193)
6. Wang J, Wang Y, Wang S, Cai J, Shi J, Sui X, Cao Y, Huang W, Chen X, Cai Z, Li H, Bardeesi AS, Zhang B, Liu M, Song W, Wang M, Xiang AP. Bone marrow-derived mesenchymal stem cell-secreted IL-8 promotes the angiogenesis and growth of colorectal cancer. Oncotarget. 2015.6.(40):42825-37.(IF:5.008)
7. Jiang MH, Li G, Liu J, Liu L, Wu B, Huang W, He W, Deng C, Wang D, Li C, Lahn BT, Shi C, Xiang AP. Nestin(+) kidney resident mesenchymal stem cells for the treatment of acute kidney ischemia injury. Biomaterials. 2015.50:56-66.(IF:8.387)
8. Li W, Huang L, Lin W, Ke Q, Chen R, Lai X, Wang X, Zhang J, Jiang M, Huang W, Wang T, Yang X, Chen Y, Song W, Xiang AP. Engraftable neural crest stem cells derived from cynomolgus monkey embryonic stem cells. Biomaterials. 2015.39:75-84.(IF:8.387)
9. Ma J, Xiong L, Chang Y, Jing X, Huang W, Hu B, Shi X, Xu W, Wang Y, Li X. Novel mutations c.[5121_5122insAG]+[6859C>T] of the SPG11 gene associated with cerebellum hypometabolism in a Chinese case of hereditary spastic paraplegia with thin corpus callosum. Parkinsonism Relat Disord. 2014.20.(2):256-9. (IF:3.794)
10. Lei J, Hui D, Huang W, Liao Y, Yang L, Liu L, Zhang Q, Qi G, Song W, Zhang Y, Xiang AP, Zhou Q. Heterogeneity of the biological properties and gene expression profiles of murine bone marrow stromal cells. Int J Biochem Cell Biol. 2013.11.45(11):2431-43. (IF:4.152)
11. Ke Q, Li L, Cai B, Liu C, Yang Y, Gao Y, Huang W, Yuan X, Wang T, Zhang Q, Harris AL, Tao L, Xiang AP. Connexin 43 is involved in the generation of human induced pluripotent stem cells. Hum Mol Genet. 2013. First published online: Feb. 18, 2013. (doi: 10.1093/hmg/ddt074.)（IF 7.636）
12. Zhao Q, Peng L, Huang W, Li Q, Pei Y, Yuan P, Zheng L, Zhang Y, Deng J, Zhong C, Hu B, Ding H, Fang W, Li R, Liao Q, Lin C, Deng W, Yan H, Hou J, Wu Q, Xu T,Liu J, Hu L, Peng T, Chen S, Lai KN, Yuen MF, Wang Y, Maini MK, Li C, Li M, Wang J, Zhang X, Sham PC, Wang J, Gao ZL, Wang Y. Rare inborn errors associated with chronic hepatitis B virus infection. Hepatology. 2012.11. 56(5):1661-70. (并列第一作者, IF:11.665)
13. Huang W, Gu H, Li R, Lou T, Zhang J, Shi W, Ye Z, Zhou Y, Li C, Xiong S, Li L, Wu C, Leung JC, Lam MF, Lai KN, Wang Y. Association of -27T>C and its haplotype at the putative promoter for IgA specific receptor gene with IgA nephropathy among Chinese Han population. Nephrol Dial Transplant. 2011. 26(8): 2537-2544. (IF:3.564)
14. Yuan P, Yue Z, Sun L, Huang W, Hu B, Yang Z, Hu Y, Xiao H, Shi H, Zhou Q, Wang Y. Novel mutation of TCIRG1 and clinical pictures of two infantile malignant osteopetrosis patients. J Bone Miner Metab. 2011. 29(2): 251-256 (IF:1.894)
15. Pei Y, Wang Y, Huang W, Hu B, Huang D, Zhou Y, Su P. Novel mutations of EXT1 and EXT2 genes among families and sporadic cases with multiple exostoses. Genet Test Mol Biomarkers. 2010 12.14(6):865-72. (IF:1.110)
16. Yue Z, Xiong S, Sun L, Huang W, Mo Y, Huang L, Jiang X, Chen S, Hu B, Wang Y. Novel compound mutations of SMARCAL1 associated with severe Schimke immuno-osseous dysplasia in a Chinese patient. Nephrol Dial Transplant. 2010. 25(5): 1697-1702. (IF:3.306)
17. Huang W, Li C, Labu, Zhou Y, Li P, Hu B, Pubuzhuoma, Gesangzhuogab, Fang J, Wang Y. High resolution linkage disequilibrium and haplotype maps for the genes in the centromeric region of chromosome 15 in Tibetans and comparisons with Han population. Chinese Sci Bull. 2006. 51(5): 542-551. (IF:0.722)
18. Huang W, Li C, Chen S, Sun J, Zhou Y, Fang J, Wang Y. Construction of fine SNP haplotypes and haplotype blocks in 5 genes in the centromere of chromosome 15 in Chinese Han subjects. Chinese Sci Bull. 2004. 49(10): 1044-1051. (IF:0.683)
19. Lou T, Zhang J, Gale DP, Rees AJ, Rhodes B, Feehally J, Li C, Li Y, Li R, Huang W, Hu B, Leung JC, Lam MF, Lai KN, Wang Y, Maxwell PH. Variation in IGHMBP2 is not associated with IgA nephropathy in independent studies of UK Caucasian and Chinese Han patients. Nephrol Dial Transplant. 2010. 25(5): 1547-1554. (IF:3.306)
20. Li R, Xue C, Li C, Lou T, Tao Y, Li Y, Huang W, Zhang J, Leung JC, Lam MF, Vyse TJ, Lai KN, Wu C, Wang Y. TRAC variants associate with IgA nephropathy. J Am Soc Nephrol. 2009. 20(6):1359-1367. (IF:7.689)
21. Xia Y, Li Y, Du Y, Yang N, Li C, Leung JC, Lam MF, Huang W, Chen S, Maxwell PH, Lai KN, Wang Y. Association of MEGSIN 2093C-2180T haplotype at the 3' untranslated region with disease severity and progression of IgA nephropathy. Nephrol Dial Transplant. 2006. 21(6):1570-1574. (IF:3.154)
22. Zhong X, Chen S, Huang W, Yang J, Chen X, Zhou Y, Zhou Q, Wang Y. Novel and known mutations of TGFBI, their genotype-phenotype correlation and structural modeling in 3 Chinese families with lattice corneal dystrophy. Mol Vis. 2010. 16: 224-230. (IF:2.541)
23. Xiong S, Hao Y, Rao S, Huang W, Hu B, Labu, Pubuzhuoma, Gesangzhuogab, Wang Y. Effects of cutoff thresholds for minor allele frequencies on HapMap resolution: A real dataset-based evaluation of the Chinese Han and Tibetan populations. Chinese Sci Bull. 2009. 54(12): 2069-2075. (IF:0.898)
24. Chen S, Zhou Y, Li X, Labu, Huang S, Huang W, Zhou C, Maxwell PH, Wang Y. Genetic and structural analyses suggest that a novel SPG3A mutation causes severe phenotypes of hereditary spastic paraplegia. Chinese Sci Bull. 2006. 51(16): 2038-2040. (IF:0.722)
25. Chen S, Song C, Guo H, Xu P, Huang W, Zhou Y, Sun J, Li CX, Du Y, Li X, Liu Z, Geng D, Maxwell PH, Zhang C, Wang Y. Distinct novel mutations affecting the same base in the NIPA1 gene cause autosomal dominant hereditary spastic paraplegia in two Chinese families. Hum Mutat.2005. 25(2): 135-141. (IF:7.923)
