博彩公司排名

On the afternoon of November 30, the 11th Congress of League Members of the Communist Youth League of Sun Yat-sen School of Medicine, Sun Yat-sen University was officially held in the Alumni Hall on the North Campus. Zhou Jing, Deputy Secretary of the Communist Youth League Committee of Sun Yat-sen University, Chen Baoyu, Deputy Secretary of the Party Committee of Sun Yat-sen School of Medicine, Ding Xiaoyi, Secretary of the Communist Youth League Committee of Sun Yat-sen School of Medicine, Ji Xiaoting, Deputy Secretary of the Communist Youth League Committee, Chen Jintang, Counselor of the 2024 grade, and Guan Qianxuan, Secretary of the Alumni Center, attended this meeting. League member representatives from all grades participated in this meeting.
First of all, the preparatory meeting of the 11th Congress of League Members of the Communist Youth League of Sun Yat-sen School of Medicine, Sun Yat-sen University was held.

The preparatory meeting listened to and voted on the "Report on the Qualification Examination of Representatives of the 11th Congress of League Members of the Communist Youth League of Sun Yat-sen School of Medicine, Sun Yat-sen University (Draft)"; the "Agenda of the 11th Congress of League Members of the Communist Youth League of Sun Yat-sen School of Medicine, Sun Yat-sen University (Draft)"; the "Election Measures for Members of the 11th Committee of the Communist Youth League of Sun Yat-sen School of Medicine, Sun Yat-sen University (Draft)"; and the "List of Chief Scrutineers and Tellers for the Election of the 11th Committee of the Communist Youth League of Sun Yat-sen School of Medicine, Sun Yat-sen University (Draft)". The convening of the preparatory meeting laid a solid foundation for the smooth progress of the formal meeting. The 11th Congress of League Members of Sun Yat-sen School of Medicine, Sun Yat-sen University opened. All participants stood up and sang the "National Anthem of the People's Republic of China" and the "Anthem of the Communist Youth League" together.

Zhou Jing, Deputy Secretary of the Communist Youth League Committee of the university, extended warm congratulations on the successful convening of the 11th Congress of League Members of Sun Yat-sen School of Medicine. She fully affirmed the hard work and outstanding achievements of teachers and students of all grades in the past three years. Meanwhile, on behalf of the Communist Youth League Committee of the university, Deputy Secretary Zhou Jing put forward three expectations for the work of the Communist Youth League of Sun Yat-sen School of Medicine: First, listen to the Party, follow the Party, and effectively enhance the political nature of the Communist Youth League. Second, inspire the vast number of league members and young people to strive for excellence, show the features of the times, and effectively enhance the advanced nature of the Communist Youth League. Third, give full play to the role of a bridge and bond connecting the Party and young people, serve the growth and development of young people, and effectively enhance the mass nature of the Communist Youth League.

At the meeting, all league member representatives listened to, deliberated on and voted on the "Work Report of the 10th Committee of the Communist Youth League of Sun Yat-sen School of Medicine, Sun Yat-sen University (Draft)". The report systematically reviewed the work of the Communist Youth League of the school since the 10th Congress of the Communist Youth League of Sun Yat-sen School of Medicine from four aspects: strengthening political guidance, continuously deepening reforms, expanding volunteer services, and focusing on the second classroom. The report believed that the Communist Youth League Committee of Sun Yat-sen School of Medicine had always put ideological guidance first, carried out theoretical learning in a down-to-earth manner, combined theory with practice, built learning platforms, adhered to deepening the reform of the league organization, strictly implemented the system of "Three Meetings, Two Systems and One Lesson", actively participated in the construction of Chinese-style modernization, adhered to the "simultaneous development of five aspects of education", focused on the second classroom, and continuously standardized and institutionalized the work of the league committee. The report also pointed out that there were still deficiencies in strengthening the integrated construction of the Party, the league and classes, further improving the contribution to the overall situation, and further deepening the organizational reform in our school. The league committee of the school will improve the work in a targeted manner, innovate the working mechanism, consolidate the organizational foundation, lead, unite and serve young students, and contribute youthful strength to promoting the development of youth undertakings and the comprehensive construction of the school.

The candidates for members of the 11th Committee of the Communist Youth League of Sun Yat-sen School of Medicine, Sun Yat-sen University made personal statements. In their statements, the candidates elaborated on their election platforms, reviewed their experiences in league affairs, put forward work ideas, and expressed their enthusiasm for serving youth affairs and playing an exemplary role.

Chen Baoyu, Deputy Secretary of the Party Committee of Sun Yat-sen School of Medicine, gave a special league class titled "Making Good Use of the 'Four Addition and Subtraction' Toolkit to Promote the Inheritance and Innovation of the Work of the Communist Youth League". He described the four additions and subtractions in the work of the league and student affairs of Sun Yat-sen School of Medicine: do "addition" in terms of political height and do "subtraction" in terms of working alone; do "addition" in terms of work depth and do "subtraction" in terms of treating people differently; do "addition" in terms of professional concentration and do "subtraction" in terms of shirking responsibilities; do "addition" in terms of the degree of closed loop and do "subtraction" in terms of weaknesses. Correct the style through learning and promote work through learning. Combine strict management with kind care. Pay attention to both quality and quantity. Have inheritance and also be able to develop. Promote the vast number of league members to jointly build, manage and make decisions on relevant league affairs and jointly create a harmonious and beautiful campus environment. Encourage league members and young people to be strivers in the new era, witnesses of the glorious history, leaders of the beautiful future, and guardians of "Healthy China". Integrate the individual into the collective, run hard on the track of youth, and strive to become builders and successors of socialism.

In accordance with the election measures and procedures of the congress, a total of 15 members of the 11th Committee of the Communist Youth League of Sun Yat-sen School of Medicine, Sun Yat-sen University were elected through the vote of all participants. Deputy Secretary Chen Baoyu announced the list of members, who are (in the order of the number of strokes of their surnames): Ding Xiaoyi, Tian Juntao, Guan Qianxuan, Li Yangfan, Li Xinyan, Wu Jiajia, Zhang Junhao, Zhang Jingxing, Chen Jieyi, Chen Jintang, Tie Hangyu, Luo Xiaoyi, Ji Xiaoting, Kang Jiaqi, Cheng Siyang.

This congress of the Communist Youth League of Sun Yat-sen School of Medicine, Sun Yat-sen University is an important meeting for league members to discuss league affairs together, gather youthful strength, show their responsibilities and promote the vigorous development of the cause of the Communist Youth League. Through this meeting, each league member representative can convey the voices of league members in a serious, responsible, comprehensive and detailed manner, and actively offer suggestions for the construction of the league organization. The league organization can optimize decisions, build a better growth platform for league members, help league members strengthen their sense of responsibility, enhance their enthusiasm for participating in league affairs, promote the close connection between the league organization and league members, deepen mutual trust, create an energetic atmosphere for the construction of the league committee, and demonstrate the spirit and mission of the Communist Youth League of Sun Yat-sen School of Medicine of striving in unity and pursuing excellence.

Keep moving forward and the future will surely be achieved. The league committee of the school will continue to move forward bravely, shoulder the mission of the times, closely follow the pulse of development, gather the strength of young people in the whole school, and continue to strive hard to practice the school motto of Sun Yat-sen University, which is "erudite, inquisitive, reflective, discerning, and steadfast". Remain true to our original aspiration, follow the Communist Party of China, shoulder responsibilities bravely and make new achievements, and let youth shine more brightly in hard work and dedication.

The inheritance of medical knowledge and skills passes down from generation to generation;
The charm of Zhongshan School of Medicine has been renowned for a hundred years.
In the centennial Sun Yat-sen University, the mountains are high and the waters are long;
With a hundred years of glory, we jointly compose a magnificent chapter.

On the morning of November 10th,
The teachers, students, and alumni of Zhongshan School of Medicine gathered together
And grandly held the 2024 Alumni Assembly of Zhongshan School of Medicine of Sun Yat-sen University
And the closing ceremony of the 16th Academic Festival in the Alumni Hall of the North Campus of Sun Yat-sen University.

Professor Zhang Qi, the deputy secretary of the Party Committee of Sun Yat-sen University, Professor Kuang Ming, the assistant president of Sun Yat-sen University and the dean of Zhongshan School of Medicine, Professor Yan Guangmei, the former deputy secretary of the Party Committee and vice president of Sun Yat-sen University, alumnus Zhang Yanhau, the former deputy director of the Health Department of Guangdong Province, Professor Xie Fukang, the former dean of Zhongshan School of Medicine, Researcher Xia Dan, the former Party secretary of Zhongshan School of Medicine, Professor Wang Tinghuai, the vice president of the Alumni Association of Sun Yat-sen University and the president of the Ke Lin Foundation, Professor Chen Minshan, the president of the Zhongshan Medical Alumni Association and the Cancer Prevention and Treatment Center of Sun Yat-sen University, Professor Bei Jinxin, the deputy director of the Office of Education Development and Alumni Affairs of Sun Yat-sen University, Long Bo, the deputy director of the Medical Department of Sun Yat-sen University and the director of the General Affairs Office, Ye Wei, the director of the Hospital Administration Office, Lin Haotian, the director of the Zhongshan Ophthalmic Center, Chen Wangnan, the Party secretary of the Guanghua School of Stomatology and the Affiliated Stomatological Hospital, Yang Jianlin, the Party secretary of the Sun Yat-sen Memorial Hospital, Rong Limin, the dean of the Third Affiliated Hospital, Chen Qikun, the Party secretary of the Seventh Affiliated Hospital, Chen Yanming, the dean of the Eighth Affiliated Hospital, Zhang June, the dean of the School of Nursing, Zhang Yuanquan, the Party secretary of the Commission for Discipline Inspection of the Cancer Prevention and Treatment Center, Li Wenmin, the deputy Party secretary of the Sixth Affiliated Hospital, Huang Yangyang, the chief accountant of the Fifth Affiliated Hospital, the guest representatives of the medical colleges and departments of the university, the leaders at all levels of the university who have worked in Zhongshan School of Medicine, and about 400 alumni, teachers, and students participated in the assembly.
The assembly was presided over by Hao Yajuan, the Party secretary of Zhongshan School of Medicine.

Speech

Professor Zhang Qi, the deputy secretary of the Party Committee of Sun Yat-sen University, delivered a speech at the assembly. On behalf of the university, Professor Zhang Qi extended the warmest welcome to the alumni from all over the world. She said that looking back on the century-old journey, Sun Yat-sen University has become more and more brilliant with the passage of time, and Zhongshan School of Medicine has successfully presented a gift to the centennial Sun Yat-sen University with its continuously rising scientific research strength and strategic ability to serve the country. The alumni of Zhongshan School of Medicine are large in number and have prominent exemplary roles, and they are the backbone of the alumni team of Sun Yat-sen University. She hoped that the alumni from all over the world would integrate their own development into the great tide of national and social development with their alma mater as the bond, and make contributions and show the responsibility of Zhongshan School of Medicine for promoting the great rejuvenation of the Chinese nation in an all-round way with Chinese modernization. Finally, she wished the assembly a complete success and sincerely invited all the alumni to come back to visit often.

School Development Report

Professor Kuang Ming, the assistant president of Sun Yat-sen University and the dean of Zhongshan School of Medicine, made the "Development Report of Zhongshan School of Medicine". Taking his own study experience as the starting point, Dean Kuang Ming introduced the basic situation of Zhongshan School of Medicine in detail to the participants and demonstrated the excellent achievements of the school in discipline construction, talent cultivation, talent introduction and cultivation, etc. Subsequently, Dean Kuang Ming shared the exploration and achievements of the school in the process of high-quality development. He emphasized that in the high-quality development of the school, the leadership of the Party is the direction, the curriculum is the key, the teaching staff is the core, innovation is the orientation, culture is the foundation, and cooperation is the driving force. Finally, Dean Kuang Ming pointed out the bottleneck problems currently restricting the development of the school, such as the teaching staff and teaching reform, and emphasized the need to continuously improve the effectiveness of the curriculum and enhance the international influence.

Alumni Center Inauguration Ceremony

Alumni are an important force in promoting the development of the school. In order to better connect with alumni, unite alumni, and serve alumni, in May this year, the school decided to establish an alumni center. The unveiling ceremony of the alumni center of Zhongshan School of Medicine was held at the assembly. The leaders and guests such as Secretary Zhang Qi, Dean Kuang Ming, Secretary Hao Yajuan, Director Long Bo, Professor Wang Tinghuai, President Chen Minshan, and Deputy Director Bei Jinxin participated in the unveiling.
To ensure the operation of the alumni center, the school hired teachers and alumni who are actively active in the front line of alumni work to hold relevant positions. Secretary Zhang Qi, Professor Yan Guangmei, Professor Xie Fukang, and Secretary Xia Dan came to the stage to issue appointment letters to the appointees. It is believed that the alumni center will surely play an active role, provide more high-quality services for the alumni, and gather more alumni resources to support the development of the school's cause!

Chorus of "China in the Lights"

The students of Zhongshan School of Medicine are not only good at studying and have excellent academic achievements, but also versatile. The choir of Zhongshan School of Medicine has won the special prize in the school-wide choral competition for two consecutive years. Youth is graceful and the mind is broad. The students of the North Campus Choir sang the song "China in the Lights" affectionately, which not only showed their good artistic accomplishment and spiritual outlook, but also sang the youth oath and the praise of the times of "I am strong for the country, please rest assured the Party".

Speech by the President of Zhongshan Medical Alumni Association

With the passage of time, the torch is passed on. The Zhongshan Medical Alumni Association has always been a strong backing for the development of the school. On behalf of the Zhongshan Medical Alumni Association, President Chen Minshan of the Zhongshan Medical Alumni Association delivered a speech, extending warm congratulations on the establishment of the Zhongshan Medical Alumni Center, expressing warm welcome to the alumni representatives from at home and abroad, and wishing the assembly a complete success. He emphasized that the alumni association can closely connect the alma mater with the alumni from all over the world because we all have the common name of "Zhongshan Medical". Finally, he issued an initiative: he hoped that the alumni at home and abroad would be more united and make new contributions to the development of Zhongshan Medical!
In the centennial Zhongshan Medical, the peaches and plums are all over the world. The alumni of Zhongshan Medical, with the earnest expectations of their alma mater, have silently dedicated and actively contributed to the medical and health undertakings in Guangdong, the Greater Bay Area, China, and even the world.

Alumni Representative Speeches

"With a Solid Foundation, Build a Career and Establish a Reputation"
Professor Zhang Jianqing, an alumnus of the class of 1989 of Zhongshan Medical, the president of the Zhongshan Medical Alumni Association in the United States, and an academician of the American Academy of Nursing Sciences, spoke as one of the alumni representatives. Professor Zhang Jianqing's speech revolved around four parts: "memories of youth", "the influence of the alma mater", "growth and insights", and "industry insights and feelings". She said that the influence of the alma mater on her is not only the imparting of knowledge, but also has deeply shaped her values and outlook on life. Looking forward to the future, the medical industry will face rapid changes and great challenges, and the alumni of Sun Yat-sen University in different fields should combine their forces and work together to release a stronger influence of Sun Yat-sen University. She emphasized that in this era full of uncertainties, we need to be people who look for opportunities in crises and build windmills when the wind comes, and make positive contributions to global health.

"For the Welfare of Society, For the Glory of the Country"

Mr. Luo Yilong, an alumnus of the class of 2000 of Zhongshan Medical, a member of the National Committee of the Chinese People's Political Consultative Conference, the vice president of the All-China Youth Federation, and the director of the Macau Health Bureau, spoke as one of the alumni representatives. Mr. Luo Yilong recalled his growth and development experience in Zhongshan Medical. His alma mater is the place that helped him with his medical enlightenment and laid a solid foundation for his development. He said that "graduates of Zhongshan Medical" are a resounding "golden business card" in Macau and a guarantee of comprehensive quality and clinical skills, and the alumni resources of Zhongshan Medical have also become a great help for the career development of the students of Zhongshan Medical. The spirit of "saving people, saving the country, and saving the world, treating diseases, treating the body, and treating the mind" of Zhongshan School of Medicine is in line with and echoes the core value of "loving the country and loving Macau" in Macau. He emphasized that he is willing to continue to be a good contact person between "Macau, China" and "Zhongshan Medical", seize the opportunity of building the Guangdong-Hong Kong-Macao Greater Bay Area, and contribute the wisdom and strength of Zhongshan Medical to the medical and health undertakings of the country and the Greater Bay Area.

"Saving People, Saving the Country, and Saving the World, Treating Diseases, Treating the Body, and Treating the Mind"

Alumnus Liu Bin, a council member of the class of 2007 of the Zhongshan Medical Alumni Association and a chief physician in the Department of Obstetrics and Gynecology of the First Affiliated Hospital of Sun Yat-sen University, spoke as one of the alumni representatives. He said that the medical students of each session, with the goal of "saving people, saving the country, and saving the world, treating diseases, treating the body, and treating the mind", are eager to learn medical knowledge and strive to grow into great doctors for the common people; generations of Zhongshan Medical people have written the medical motto of Zhongshan Medical on the land of the motherland, all over the world, and in the hearts of every patient we have treated with their wisdom, sweat, and even lives, and the future students of Zhongshan Medical will also be like this. The development of medical technology is changing with each passing day, and the doctors in the new era face new challenges and opportunities. Therefore, he entrusted the medical students in the new era to have new responsibilities and new achievements: first, have solid knowledge and excellent basic clinical skills; second, have an international perspective and be good at innovation and creation; third, have a kind heart and a noble ideal.

Donation Scholarship Awarding Ceremony

The "Yixian Fate" Physiology Scholarship was set up by the donation of alumnus Zhu Hui, a graduate student majoring in Physiology in 1987, and alumnus Wu Wenlei, an undergraduate majoring in Stomatology in 1985, to reward the students with excellent grades in the "Physiology" course. The 04 Research Xinglin Senior Scholarship was set up by the donation of the graduate student class of 2004 to reward the undergraduate students with excellent academic achievements. The donation scholarship awarding ceremony was held at the assembly. Alumnus Zhu Hui presented the certificates of the Yixian Fate Physiology Scholarship to Zhang Zhenxia, Xiong Haiting, Du Yuhan, and Tang Shile. Alumni Kong Xiaoping and Xu Jiajian, on behalf of the graduate student alumni of 2004, presented the certificates to the recipients of the 04 Research Xinglin Senior Scholarship, Guo Hongbo, Zheng Mixue, Chen Yanlin, Gao Zirui, Wu Jiajia, and Chen Juexiao.
Xiong Haiting, a student representative of the award-winning students and a student of the eight-year clinical medicine program in 2022, delivered an acceptance speech. Student Haiting said that on the occasion of the approaching centennial anniversary of Sun Yat-sen University, it is an honor to be awarded the Yixian Fate Physiology Scholarship in her academic journey. She extended the highest respect and sincere gratitude to the donors of the Yixian Fate Physiology Scholarship, Zhu Hui and Wu Wenlei. She mentioned that the receipt of the Yixian Fate Physiology Scholarship is not only an recognition of our past efforts, but also an expectation for our future. It is an incentive and a responsibility. In the future, she will actively engage in the research of physiology and continue to move forward on the path of medicine, exploring the unknown and pursuing excellence.

Academic Festival Commendation Ceremony

The Academic Festival of Zhongshan School of Medicine, as a classic academic brand of the school, continues the fearless pursuit of truth, the in-depth exploration of the essence of academics, and the unremitting climb of the scientific research peak of the generations of Zhongshan Medical people. The 16th Academic Festival held this year held 20 wonderful academic report sessions and a series of activities, inviting 188 well-known experts and scholars at home and abroad to communicate and share with the teachers and students of the school on the same stage, including 10 academicians and 35 foreign experts, and a total of more than 3,300 people participated in the activities.
The commendation ceremony of the Youth Academic Salon and Experimental Technology Salon of the 16th Academic Festival of Zhongshan School of Medicine was held at the assembly. Professor Zhou Jiaguo, the vice dean of Zhongshan School of Medicine, and Professor Deng Kai, the vice dean of Zhongshan School of Medicine, presented certificates to the third prize winners. Professor Gao Guoquan, the former vice dean of Zhongshan School of Medicine, and Professor Liu Xianguo, the former vice dean of Zhongshan School of Medicine, presented certificates to the second prize winners. Professor Yan Guangmei of Zhongshan School of Medicine and Professor Zhang Hongqi, a master alumnus of the class of 1990 and a professor at the School of Basic Medical Sciences of Fudan University, presented certificates to the first prize winners.

Recitation

Ke Lin is known as the "master of Zhongshan Medical in one generation". To celebrate the centennial anniversary of the alma mater, the school organized and invited the modern Cantonese opera "Silent Merit" with the red doctor Ke Lin as the protagonist to perform three times on campus, which won wide acclaim. At the end of the assembly, the participants reproduced the climax of the play and recited "My Zhongshan Medical, My Sun Yat-sen University" aloud, expressing the feelings of the people of Zhongshan Medical.

My Zhongshan Medical, My Sun Yat-sen University,
Has written a glorious history and opened a new chapter.
My Zhongshan Medical, My Sun Yat-sen University,
May you grow taller like bamboo joints and be as tall and red as kapok.
My Zhongshan Medical, My Sun Yat-sen University,
May you be as holy and flawless as apricot forest and as lush and leafy as banyan trees.
My Zhongshan Medical, My Sun Yat-sen University,
May you be as majestic and evergreen as Yunshan Mountain and be passed down for a hundred generations like the Pearl River.
Finally, in the melodious chorus of the school song, the 2024 Alumni Assembly and the closing ceremony of the 16th Academic Festival of Zhongshan School of Medicine of Sun Yat-sen University came to a successful conclusion.
The centennial medical school has a profound heritage;
The apricot forest is full of spring and fruitful;
The alumni gather and enjoy the friendship.
Entering a new journey,
Zhongshan School of Medicine will, with a fuller spirit and a higher fighting spirit,
Take root in the land of China, base itself on the Guangdong-Hong Kong-Macao Greater Bay Area,
Continue to move forward in the same direction and at the same pace as the development of the Party and the country.
Wish the alumni happiness and well-being and strive for new heights;
Wish Zhongshan School of Medicine the pursuit of excellence and perseverance;
Wish Sun Yat-sen University new achievements and new glories!

In recent years, with the development of synthetic biology technology, there have been reports of using synthetic brain organoids, spinal cord organoids, and spinal cord-like tissues to repair central nervous system injuries. However, there is a lack of literature on the design and synthesis of organoids/tissues for repairing peripheral nerve defects. Therefore, this study follows the tissue engineering simulation design concept, using synthetic biology technology to load neurotrophin-3 (NT-3) overexpressing genetically engineered Schwann cells (SCs) within a decellularized optic nerve (DON) scaffold with natural uniform longitudinal channels. An artificial peripheral nerve tissue (peripheral nerve tissueoid, PNT) rich in laminin (LAM or LN) and NT-3 and other bioactive factors is manufactured to simulate the structure of peripheral nerve tissue in vitro. It is then transplanted to the site of sciatic nerve defect in an attempt to induce the longitudinal regrowth of axons in neurons expressing LAM or LN receptors and NT-3 receptors, restoring the function of the sciatic nerve and exploring the mechanism by which PNT grafts induce sciatic nerve regeneration.

To verify the above hypothesis, the joint team of Professor Zeng Yuanshan, Professor Xu Yangbin and Deputy Chief Physician Zhu Zhaowei from the First Affiliated Hospital of Sun Yat-sen University, Deputy Chief Physician He Bo from the Third Affiliated Hospital, and Deputy Researcher Li Ge from Guangdong Provincial People's Hospital transplanted PNT at the site of sciatic nerve defect. The results showed that PNT transplantation based on synthetic biology technology can repair the structure of the sciatic nerve defect and restore the sensory and motor functions of the paralyzed limb. This may involve inducing the interaction between NT-3 and its receptor TrkC cells, as well as the interaction between laminin and its receptor integrin αVβ6 axons, which play a role in chemotaxis, adhesion, and intrinsic drive mechanisms in promoting the targeted regeneration of neuronal axons within the PNT.

The results of testing the PNT showed that the unique bioactive matrix components LAMC3 or LN on the longitudinal channel walls of DON can form an NT-3-enriched area by binding with NT-3 secreted by genetically engineered Schwann cells (NT-3-SCs). The NT-3-SCs located in the PNT can also bind to the self-secreted NT-3 through their cell surface NT-3 receptor TrkC: on the one hand, it promotes the better colonization of NT-3-SCs in the NT-3-deposited area, forming a dynamic bioactive niche of PNT; on the other hand, the interaction between NT-3 and TrkC (ligand and receptor) further activates NT-3-SCs to better survive and secrete various neurotrophic factors, forming a microenvironment and structural basis for inducing the regrowth of neuronal axon bundles.

Transplanting the above PNT into the sciatic nerve defect site of rats, the animals survived for 8 weeks postoperatively. Through behavioral testing of the animals and detection of nerve-related tissues and functions, the results showed that the sciatic nerve index, limb rotation angle, and mechanical pain sensitivity test values of the PNT transplantation group were close to those of the autologous peripheral nerve transplantation group, with significant improvement compared to other transplantation control groups. Nerve-related tissue detection showed that compared with other transplantation control groups, the PNT transplantation group could promote the faster passage of regenerating axons across the sciatic nerve defect/transplant site to the target tissue and re-form myelin sheaths, thereby improving the sensory and motor functions of target skin and muscle tissues that had lost nerve innervation. Anterograde and retrograde tracing of nerve tissues indicated that regardless of whether in the PNT graft or at the distal end of the sciatic nerve defect/transplant site, adeno-associated virus (AAV) labeled dorsal root ganglion (DRG) neurons and their regenerated calcitonin gene-related peptide-positive axons could specifically express TrkC.

Transcriptome analysis of DRGs innervating the sciatic nerve defect/transplant side of the hind limb in the PNT transplantation group and the simple DON transplantation group revealed the potential molecular mechanisms of neuronal axon regeneration. The results revealed that the PNT graft provides a biophysical bridge at the sciatic nerve defect/transplant site to induce DRG neuronal axon regeneration. The NT-3 enriched on the longitudinal channel walls of the PNT by the genetically engineered Schwann cells activates DRG neurons and their axons to express the receptors TrkC and integrin αVβ6 (Integrin αVβ6) that combine with them, thereby activating the PI3K/AKT signaling pathway related to the intrinsic drive of neurons and enhancing the efficacy of long-distance axon regeneration.

Schematic diagram shows: (1) LN or LAMININ on the PNT channel wall can bind with NT-3 to form an NT-3-enriched area, which is conducive to the colonization and growth of genetically engineered Schwann cells (NT-3-S) expressing TrkC and forming a niche for regenerating axons to form myelin sheaths on the PNT. (2) The continuous secretion of NT-3 by the PNT can promote the extension of TrkC-expressing neuronal axons to the sciatic nerve defect/transplant site, which may involve the interaction between NT-3 and TrkC as well as LAMININ and integrin αVβ6.

Original Article Link: //pubmed.ncbi.nlm.nih.gov/39531746/

On November 12, Xi Jinping, General Secretary of the Communist Party of China Central Committee, President of the People's Republic of China, and Chairperson of the Central Military Commission, sent a letter to congratulate Sun Yat-sen University on its 100th anniversary and extended congratulations to all teachers, students, staff, and alumni at home and abroad.
In the congratulatory letter, Xi Jinping emphasized that, at a new starting point, he hopes that Sun Yat-sen University will adhere to the guidance of Xi Jinping Thought on Socialism with Chinese Characteristics for a New Era, inherit the red gene, adhere to educating people for the Party and cultivating talents for the country, focus on the major national strategies and the development needs of the Guangdong-Hong Kong-Macao Greater Bay Area, promote education reform and development, scientific and technological innovation, and talent cultivation in an integrated manner, accelerate the construction of a world-class university with Chinese characteristics, and make new and greater contributions to building a strong education country and promoting Chinese modernization.
On the afternoon of November 13, Zhongshan School of Medicine held an enlarged study session of the Theoretical Learning Center Group of the Party Committee to specifically convey and study the spirit of General Secretary Xi Jinping's congratulatory letter and to study and deploy the work of the school in learning, implementing, and fulfilling it. Hao Yajuan, Secretary of the Party Committee, presided over the meeting. Professor Kuang Ming, Assistant President of Sun Yat-sen University and Dean of Zhongshan School of Medicine, and other members of the Party and administrative leadership teams and members of the Party Committee attended the meeting. Secretaries and members of the Party branches and other relevant personnel were present as observers.
Dean Kuang Ming said that General Secretary Xi Jinping's congratulatory letter is far-sighted, profound in connotation, and of great significance, fully reflecting the importance and care that the Party Central Committee with Comrade Xi Jinping at its core attaches to the cause of higher education and Sun Yat-sen University. Standing at the starting point of Sun Yat-sen University's new century-long journey, Zhongshan School of Medicine should adhere to inheriting the red gene, adhere to the "Four Orientations", focus on the major strategic needs of the country and the construction of the Guangdong-Hong Kong-Macao Greater Bay Area, unite and gather alumni at home and abroad, and write a new chapter around promoting education reform and building a strong education country. The congratulatory letter has pointed out the direction for our development. The whole school should strengthen learning, combine it with the actual development of the school, give full play to the leading role and the spirit of being the master in the medical education of the university, emancipate the mind, work hard with a sense of responsibility, and contribute to the construction of a Healthy China.

Secretary Hao Yajuan said that General Secretary Xi Jinping's congratulatory letter has made every member of Sun Yat-sen University feel extremely honored and inspired. We should keep in mind the entrustment, bravely shoulder the mission, and quickly set off an upsurge in learning and implementing the spirit of General Secretary Xi Jinping's congratulatory letter. Party members and cadres should take the lead in learning, achieving a high degree of ideological consciousness and firm and powerful actions. We should also closely combine the study of the spirit of General Secretary Xi Jinping's congratulatory letter with the study and implementation of the spirit of the Third Plenary Session of the 20th CPC Central Committee and the spirit of the National Education Conference, continuously make efforts in cultivating students' sense of patriotism and family affection, cultivating noble teachers' ethics and styles, and improving the internal governance of the school, transform the learning achievements into work efficiency, promote the high-quality development of the school's undertakings, and step into the next century-long journey with a high-spirited attitude.

General Secretary Xi Jinping's congratulatory letter has aroused a strong response among the teachers, students, and staff of the school. Everyone unanimously said that they will keep in mind General Secretary Xi Jinping's earnest entrustment, bravely shoulder the mission of the times, and make new and greater contributions to building a strong education country and promoting Chinese modernization.

Lipotoxicity plays a significant role in the development of type 2 diabetes, with the ectopic deposition of lipids in cells causing chronic organ damage and dysfunction, which is an important mechanism for diabetic complications. Clinically, lipid-lowering and lipid control are important strategies in the prevention and treatment of diabetes and its complications. The latest guidelines for the prevention and treatment of type 2 diabetes from the Chinese Medical Association and the American Diabetes Association explicitly recommend that diabetic patients should receive statin drugs for lipid-lowering treatment.

However, clinical research data suggests the complexity of "lipid-lowering" in diabetic patients. On one hand, long-term use of statin drugs can affect blood sugar levels, leading to increased blood sugar and insulin resistance. Our institute's Professor Cai Weibin's team, in previous research (Nat Commun. 2023 Jan 24;14(1):390.), used a diabetic mouse model to observe the effects of statin drug use over 40 weeks, providing long-term research data that is difficult to achieve clinically. The study confirmed that long-term use of statin drugs in the context of diabetes can lead to lipid deposition and lipotoxicity in the kidneys, exacerbating the progression of diabetic nephropathy, preliminarily confirming that lipid-lowering does not equate to reducing organ lipids. On the other hand, even after intensive statin therapy for diabetic patients, 77% of cardiovascular events cannot be avoided, meaning that there is still residual risk of cardiovascular events. Whether there is ectopic lipid deposition in myocardial cells in the context of diabetes that exacerbates myocardial lipotoxicity has not yet been confirmed. Clarifying this key scientific question is related to the long-term prognosis of myocardial damage in diabetic patients.

On October 30, 2024, Professor Cai Weibin's research group from Sun Yat-sen University's School of Medicine published a research paper titled "SREBP1 induction mediates long-term statins therapy related myocardial lipid peroxidation and lipid deposition in TIIDM mice" in the journal Redox Biol. The study confirmed that under the context of diabetes, long-term statin therapy for lipid-lowering treatment abnormally activates the transcriptional regulatory factor SREBP1, which is important for lipid synthesis in myocardial cells, leading to increased myocardial lipid deposition and lipid peroxidation, ultimately accelerating the progression of diabetic cardiomyopathy.

The study used three classic type 2 diabetes mouse models: db/db mice, KKay mice, and streptozotocin (STZ)-induced type 2 diabetes mice, to establish a comparative medical model that simulates the long-term statin therapy for lipid-lowering treatment in type 2 diabetic patients. The study found that after long-term statin therapy, all three types of diabetic mice showed明显的下降 in cardiac function, increased myocardial damage, accompanied by lipid deposition and lipid peroxidation. The research team further used SREBP1 knockdown mice, constructed TIIDM mice through a high-fat diet (HFD)/STZ, to study the role of SREBP1 in myocardial lipid metabolism after statin treatment. Mechanistically, statin drugs promote the cleavage of SREBP1 into the nucleus of myocardial cells, and SREBP1 knockdown can reverse the lipid deposition caused by long-term statin therapy in myocardial cells.

It is worth noting that in a cohort of people with diabetes and myocardial injury, the research team found significant activation of SREBP1, which is negatively correlated with myocardial lipid peroxidation and myocardial fibrosis, emphasizing the potential of SREBP1 as a therapeutic target for reducing lipid deposition in the myocardium of diabetic patients.

The study was supported by the National Key R&D Program, the National Natural Science Foundation of China, the Guangdong Basic and Applied Basic Research Fund, and the Guangzhou Science and Technology Program. Huang Tongsheng, a 2019 Ph.D. student, and Wu Teng, a 2020 Ph.D. student, are the co-first authors of the paper. Professor Cai Weibin from our institute, Professor Ren Meng from Sun Yat-sen Memorial Hospital of Sun Yat-sen University, and Professor Wang Hong from Temple University School of Medicine are the co-corresponding authors of the paper. The study received strong support from Professor Zhang Yuling from Sun Yat-sen Memorial Hospital, Professor Yang Xiaofeng from Temple University School of Medicine, and the assistance of teachers from the Experimental Animal Center of Sun Yat-sen University and the Scientific Research Instrument Platform of the School of Medicine.

Original Article Link: 

//www.sciencedirect.com/science/article/pii/S2213231724003902?via%3Dihub. 

Within the family of blood stem cells, there are both hematopoietic stem cells (HSCs) that maintain normal hematopoiesis and leukemia stem cells (LSCs) that can lead to relapse after leukemia treatment. When HSCs transition from a quiescent state to an activated state, they may encounter functional failure, which is not only related to the occurrence of clinical diseases such as aplastic anemia and bone marrow failure but also the biggest challenge faced by HSCs during ex vivo expansion.

On September 20, 2024, Professors Wen Zhuoqian and Zhao Meng from our institute published a review article titled "Metabolic Regulation in Normal and Leukemic Stem Cells" in Trends in Pharmacological Sciences, a subsidiary journal of Cell. In the article, based on the latest research results of their research group, the two professors comprehensively sorted out how cellular metabolism finely regulates the metabolic activities and functional maintenance of HSCs, and discussed corresponding clinical intervention strategies. At the same time, the article deeply elaborated on how LSCs rely on their unique metabolic characteristics to achieve chemoresistance and immune evasion mechanisms. The paper pointed out that maintaining a low-energy metabolic quiescent state is key to the long-term self-renewal of HSCs and is also an important mechanism for the chemoresistance of LSCs. In addition, the article also summarized clinical drugs and strategies for treating blood diseases by intervening in the energy metabolic state of blood stem cells.

Corresponding author Professor Zhao Meng, doctoral supervisor, is a talent introduced by Sun Yat-sen University and has received support from several national high-level talent projects. She mainly engages in hematopoietic stem cell research and has published more than 20 papers as the corresponding author in academic journals such as Nature Cell Biology (2 papers), Cell Stem Cell, Blood (3 papers), JEM, eLife, Adv Sci, JHO, with a total citation of more than 3500 times. She is the winner of the 2024 China Stem Cell Research Innovation Scientist Award, and her research results in 2022 and 2023 were successively selected as the top ten research progresses in Chinese hematology.

The first author, Associate Professor Wen Zhuoqian, doctoral supervisor, is a talent introduced by Sun Yat-sen University and a "Yat-sen Scholar Plan" new star scholar. He mainly researches the molecular regulatory mechanisms of the occurrence and relapse of acute myeloid leukemia (AML) and develops corresponding treatment plans. In recent years, he has published more than 10 papers as the first or corresponding author in academic journals such as Blood (5 papers), Leukemia (2 papers).

Pleiotropy is a fundamental concept in genetics, referring to the phenomenon where a single gene can affect multiple phenotypic traits. Recent studies have shown that many genes exhibit pleiotropy, meaning that a single gene can cause changes in various biochemical and physiological characteristics, thereby having a broad impact on biological processes. However, pleiotropy can cause evolutionary constraints. When a gene mutates and simultaneously affects multiple traits, this mutation is usually beneficial for only one specific trait while being detrimental to others. Since evolution largely depends on the overall changes in related traits, changes in a single beneficial trait are often difficult to detect and retain, thus pleiotropy actually limits the evolutionary adaptation of organisms. This raises a puzzling question: if pleiotropy can hinder evolution, how did such widespread genetic pleiotropy originate and evolve?

Recently, the collaborative team of Professor Chen Xiaoshu from Sun Yat-sen University's School of Medicine and Professor He Xionglei from the School of Life Sciences published a research paper titled "Most pleiotropic effects of gene knockouts are evolutionarily transient in yeasts" in Molecular Biology and Evolution, conducting a comprehensive study on the knockout effects of transcription factors to reveal the evolutionary characteristics of pleiotropy.

The researchers conducted parallel gene knockout experiments on 100 transcription factors in two strains of Saccharomyces cerevisiae, systematically quantifying the pleiotropic effects of these knockouts on gene expression levels. Results from both strains confirmed the widespread presence of pleiotropic effects, where the knockout of a single gene typically affects the expression levels of multiple genes. Notably, the pleiotropic effects caused by knockouts varied rapidly between strains with different genetic backgrounds, with about 85% being non-conserved. Further analysis indicated that conserved effects are often directly related to the function of the knocked-out transcription factor, while non-conserved effects seem to be more transient responses. Additionally, the researchers measured 184 yeast cell morphological traits of these knockout strains and observed patterns consistent with gene expression.

Since gene knockouts can be considered a form of mutation, the researchers speculated that the reason for this instability could be traced back to the adaptive process of mutations. Whenever a new mutation arises, it may disrupt the homeostasis within the cell in an unknown way, leading to various responses. In this process, natural selection tends to retain adaptive responses while gradually eliminating those that are maladaptive or slightly harmful.

Therefore, the low conservation of pleiotropy may be the result of the rapid loss and acquisition of pleiotropic functions in different genetic backgrounds after divergence. To test this hypothesis, the researchers further studied the pleiotropic effects of genetic variation in a population of about 1000 hybrid offspring from the two strains. They observed that newly evolved expression quantitative trait loci (eQTL) affect the expression of more genes than ancient eQTL. This suggests that natural selection is gradually eliminating maladaptive or slightly harmful pleiotropic responses.

Based on these findings, the researchers proposed a new model for the evolution of pleiotropy: most mutations originate from a highly pleiotropic natural state, and evolution gradually prunes harmful pleiotropic effects, retaining only adaptive and conserved effects, making most pleiotropic effects evolutionarily transient. This model indicates a two-way interaction between pleiotropy and evolution, thus potentially alleviating the constraints of pleiotropy on evolution to some extent. Furthermore, the study's results that pleiotropic effects of knockouts are evolutionarily transient suggest that most knockout effects need to be re-evaluated for their biological significance, and their conservation should be considered a priority when understanding phenotypic effects.

Professor Chen Xiaoshu and Professor He Xionglei from Sun Yat-sen University are the co-corresponding authors of the article, and Associate Professor Liu Li is the sole first author of the article.

Original Article Link: //doi.org/10.1093/molbev/msae189

From August 23 to August 24, the final of the 10th National Undergraduate Forum on Basic Medical Innovation Research and Experimental Design and the 2024 "Belt and Road" International Undergraduate Medical Basic Research Innovation Design Forum were held on the South Campus of Sun Yat-sen University. This competition was sponsored by the Basic Medicine Group of the Joint Conference of National Experimental Teaching Demonstration Centers in Colleges and Universities and the Collaborative Education Working Group for Innovation and Entrepreneurship in Basic Medicine in Colleges and Universities. It was officially included in the Catalogue of Competitions for College Students in Regular Institutions of Higher Education released by the Chinese Society of Higher Education in 2023. Both the number of participating universities and the number of participants in this year's competition reached the highest level in history.

Ten student teams from Zhongshan School of Medicine, under the careful guidance of instructors and after intensive training and drills in the school, went through two days of fierce competition in the final. Eventually, with a rigorous academic style, solid foundation and confident demeanor, they stood out from 876 participating teams and won 6 gold medals, 3 silver medals and 1 bronze medal, as well as 2 Best Style Awards and 1 Best Teamwork Award, refreshing the award record once again!
The School of Medicine, Guanghua School of Stomatology, School of Public Health and School of Pharmaceutical Sciences, which were coordinated by our school for participation, also achieved excellent results with a total of 5 gold medals, 2 silver medals and 2 bronze medals.

Since the launch of this year's competition, our school has made every effort to improve the overall level of the participating teams with a high sense of responsibility and mission. From taking the lead in organizing the intra-school selection competitions of various colleges in the Medical Department, to undertaking the organization work of the competitions for the participating colleges, and until finally advancing to the national final, our school has continuously strengthened the overall organization within the school, carried out intensive competition training in the form of combining "instructors' individual guidance + school's centralized drills", and simultaneously provided training for the participating students from brother colleges such as the School of Medicine.

From the fierce competition in the regional competitions to the peak showdown in the national competition, Zhongshan School of Medicine not only achieved the best result in the history of the school in this competition but also helped the colleges in the Medical Department of our university jointly maintain the proud achievement of ranking first in the total number of gold medals in the country. The attainment of this result is the best affirmation for every participant and striver, and vividly demonstrates the good effect of the school in practicing the fine tradition of "Three Basics, Three Stricts and Three Earlies". Zhongshan School of Medicine will continue to pursue excellence, promote teaching, learning and reform through competitions, and contribute to cultivating more medical talents with an international perspective and innovative ability.

Chromatin loop extrusion is a fundamental mechanism for various molecular events such as chromosome packaging, separation, DNA repair, and RNA transcription. Recent studies have shown that cohesin-mediated loop extrusion plays a significant role in antibody diversification by promoting V(D)J recombination in developing B cells and class switch recombination (CSR) in mature B cells. The loop extrusion model suggests that during CSR, cohesin-mediated loops can extrude the IgH locus into loops, mediating the alignment, breakage, and joining of Sm and downstream transcriptionally activated S regions at the CSR centers, with the downstream Cx replacing the Cm exon, allowing the antibody to switch from IgM to other subtypes (IgG, IgE, or IgA, etc.) to exert different effector functions. Studies have shown that non-CTCF factors, including transcription, can act as barriers to regulate loop extrusion. However, how transcription regulates loop extrusion in the context of CSR is still unclear.

Recently, Professor Dong Junchao's team from Sun Yat-sen University's School of Medicine, in collaboration with Professor Chen Chun's team from the Seventh Affiliated Hospital of Sun Yat-sen University, published an article titled "USP7 promotes IgA class switching through stabilizing RUNX3 for germline transcription activation" in Cell Reports. The study indicates that USP7 and TGFb control the specificity of the CSR process by regulating the movement of cohesin-mediated extrusion loops towards the upstream S region by modulating Sa germline transcription activity.

In this study, the team constructed USP7-related mutant cells on the classic CH12 cell model. Compared with wild-type cells, under a-CD40/IL-4 stimulation, USP7-deficient cells showed significantly reduced Sa germline transcription (GLT) and CSR, while Sg GLT and CSR levels significantly increased. After adding TGFb to the above cells, the levels of Sa GLT and CSR in USP7-deficient cells significantly increased, while Sg GLT and CSR were significantly inhibited. The negative correlation between Sa and upstream Sg transcription and class switching suggests that Sa transcription can act as a barrier, inhibiting loop extrusion towards the upstream Sg region. This speculation was confirmed by 4C-Seq, indicating that USP7-mediated Sa germline transcription is crucial for Sa/CSR center interaction, and TGF-b compensates for the loss of interaction caused by USP7 knockout.

So, how do USP7 and TGFb regulate Sa transcription? By detecting the impact of USP7 on the protein levels of several transcription factors bound to the Ia promoter region, the research team found that USP7 can promote RUNX3 protein expression by interacting with the transcription factor RUNX3. USP7 can stabilize RUNX3 protein through its deubiquitinating enzyme activity, and TGFb can efficiently induce RUNX3 transcription, returning RUNX3 protein levels in USP7-deficient cells to wild-type levels.

In summary, this study, using a cell model where transcriptional activity can be inhibited and reversed, confirms the importance of the loop extrusion model for the production of B cell antibody region germline transcription, the three-dimensional conformation of the antibody gene locus, and the CSR process. It also discovers the regulatory effects of the TGF-b signaling pathway and the deubiquitinating enzyme USP7 on the transcription factor RUNX3 at both transcriptional and post-translational modification levels, a regulatory mechanism that may also apply to other non-B cell scenarios involving TGF-b and USP7. Furthermore, given USP7's specific promotion of IgA rather than IgG antibodies, small molecule inhibitors targeting USP7's deubiquitinating enzyme activity may have potential therapeutic effects in IgA-induced inflammation, autoimmune, and other immune disorders.

Professor Dong Junchao from Sun Yat-sen University's School of Medicine and Professor Chen Chun from the Seventh Affiliated Hospital of Sun Yat-sen University are the co-corresponding authors; team members Dr. Zhao Bo and Dr. Xia Zhigang are the co-first authors. Professor Zhang Xuefei from the Peking University Biomedical Frontier Innovation Center, Researcher Zhu Chengming from the Seventh Affiliated Hospital of Sun Yat-sen University, Professor Liang Jintang from the Chinese University of Hong Kong, and Deputy Chief Physician Huang Junbin from the Seventh Affiliated Hospital of Sun Yat-sen University also made significant contributions to this research.

Original Article Link: //doi.org/10.1016/j.celrep.2024.114194

The formation of our limbs during development is not a one-step process, but rather a complex cellular evolution process. Limb development abnormalities are one of the most commonly reported birth syndromes worldwide, with one case found in approximately every 500 newborns globally. As limb development involves two classic developmental issues—cell fate determination and spatial positioning— it has long been studied as an important model in developmental biology. In recent years, the development of single-cell technology has made it possible to directly study cell fate determination and spatial positioning in human limb development.

On December 6, 2023, Professor Zhang Hongbo's research group from Sun Yat-sen School of Medicine, along with researchers from the Sanger Institute, published a research paper titled "A human embryonic limb cell atlas resolved in space and time" in the journal Nature. The study reported the establishment of the first single-cell atlas of human limb development based on single-cell transcriptomics and spatial transcriptomics technologies, deciphering the cellular evolution pathways and cellular spatial positioning determination processes from the early stages of limb development to complete morphological formation.

In this study, Professor Zhang Hongbo's research group from Sun Yat-sen University, in collaboration with researchers from the Sanger Institute, first used single-cell transcriptomics technology to leverage the continuity of the cell evolution process during limb development. They sampled from multiple periods and different individuals to create a continuous evolution map of all cell types in human limb development. Subsequently, the researchers combined spatial transcriptomics technology to accurately locate the exact positions of cells in the developing limbs and the rules of cell position changes over developmental time. With this atlas, researchers can track cell types produced at specific times and regions, identify new cell types, and provide detailed characterizations of the specific gene expression programs activated in these cell types. These temporal gene expression patterns often play a crucial regulatory role in shaping the growing limbs.

As part of the research, the researchers demonstrated that these gene patterns affect the formation of fingers and toes, identifying key regulatory genes. Staining of tissues clearly revealed how the original cell types that make up fingers and toes arrange themselves differently to form the rudiments of fingers and toes, and identified the specific expression genes of the corresponding cell types. When the expression of these genes does not follow established patterns, it can lead to specific developmental phenotypes, such as brachydactyly (short fingers or toes) and polydactyly (extra fingers or toes) developmental abnormalities, among others.

The researchers also focused on the cell development patterns of skeletal muscles that make up the limbs and tissues developed from limb mesenchymal cells. The study clearly identified two pathways for the formation of human skeletal muscles and specific expression genes for each pathway, which provides important clues for further determining the key regulatory genes and mechanisms of cell fate divergence in skeletal muscle formation. Interestingly, the study found that the PITX1 gene, which regulates the differential determination of upper and lower limbs, may have a unified mechanism in regulating the formation of skeletal muscles in different limbs. The research team also obtained single-cell transcriptome data for the development of mouse limbs, finding that many aspects of limb development are highly similar between humans and mice.

In summary, the study parsed the complex anatomical structure of the human limb at the single-cell level and in 2D spatial structure, providing an important reference for further cross-species in-depth study of the detailed regulatory mechanisms of limb development, the cellular physiological mechanisms of limb development abnormalities, and broader developmental and regenerative processes of cell fate regulation mechanisms and spatial positioning construction mechanisms.

Professor Zhang Hongbo from Sun Yat-sen University and Professor Sarah Teichmann from the Sanger Institute are the co-corresponding authors of the paper. Zhang Bao (a postdoctoral fellow in Professor Zhang Hongbo's research group, originally a doctoral student), Peng He (a postdoctoral fellow in Professor Sarah Teichmann's research group), John Lawrence (a doctoral student in Professor Sarah Teichmann's research group), and Wang Shuaiyu (a postdoctoral fellow in Professor Zhang Hongbo's research group, now working at Guangzhou Women and Children's Medical Center) are the co-first authors of the paper. The research was supported by the National Key R&D Program, the National Natural Science Foundation of China, the UK Wellcome Trust, and other funding sources.

Professor Zhang Hongbo's research group from Sun Yat-sen University's Sun Yat-sen School of Medicine uses single-cell sequencing, biochemistry and molecular cell biology, model animals, and human disease models to study the impact of cellular fate in processes such as energy metabolism, aging, development, and regeneration. Postdocs interested in the above directions are welcome to join, and inquiries for graduate studies are also welcome.

Original Article Link: //www.nature.com/articles/s41586-023-06806-x