个人简介
赵蔚 博士,中山大学教授,博士生导师,海外高层次人才(青年),中山大学引进人才,广东省脑发育与脑病防治学会副理事长,广东省解剖学会常务理事。赵蔚在南京大学获生物学士和博士学位,在美国Baylor College of Medicine从事博士后研究,然后到美国康奈尔大学Weill医学院附属Methodist医院任助理研究员,2015年来到博彩公司排名-博彩公司评级 担任教授、博导。
目前的研究围绕肿瘤微环境表观遗传调控领域,具体包括:1.通过单细胞转录组和表观组分析揭示肿瘤微环境细胞亚群并发现关键表观遗传因子;2.探究RNA修饰和组蛋白修饰的调控因子在肿瘤微环境细胞的命运决定中的功能; 3. 发展表观遗传药物在肿瘤治疗中的应用。
迄今已在 Cell(2013,一作),Cancer Research(2019,通讯), Science Advances(2020,通讯), Signal Transduction and Targeted Therapy(2020,通讯),Advanced Science (2020,2021,通讯),等国际权威学术期刊发表论文30余篇,其中通讯作者(含共同通讯作者)论文18篇。
研究生培养
欢迎热爱科研且具有坚韧性格的研究生的加入,赵蔚教授将给予充分的指导和最大程度的支持,目前团队的研究生已有多人在国际有影响力的刊物上发表高水平论文。
关于赵蔚教授团队更多信息请访问实验室网站://www.zhaolaboratory.com/
学术成果
近三年通讯作者论文发表情况(*为通讯作者)
- Pharmacological Inhibition of Core Regulatory Circuitry Liquid-liquid Phase Separation Suppresses Metastasis and Chemoresistance in Osteosarcoma. Lu B, Zou C, Yang M, He Y, He J, Zhang C, Chen S, Yu J, Liu K, Cao Q, and Zhao W* Advanced Science (Accept). 2021. 影响因子:16.806
- Interplay of m6A and histone modifications contributes to temozolomide resistance in glioblastoma. Li FX, Chen SY, Yu JM, Gao ZX, Sun ZY, Yi Y, Long T, Zhang CX, Li YZ, Pan YM, Qin CY, Long WY*, Liu Q*, Zhao W*. Clinical and Translational Medicine (Accept). 2021. 影响因子:11.429
- Nanomaterial-Facilitated Cyclin Dependent Kinase 7 Inhibition Suppresses Gallbladder Cancer Progression via Targeting Transcriptional Addiction. Huang CS, Xu QC, Dai CL, Wang LY, Tien YC, Li FX, Su Q, Huang XT, Wu J, Zhao W*, Yin XY. ACS Nano (Accept).2021. 影响因子:15.881
- HNRNPC impedes m6A-dependent anti-metastatic alternative splicing events in pancreatic ductal adenocarcinoma. Huang XT, Li JH, Zhu XX, Huang CS, Gao ZX, QC, Zhao W*, Yin XY*. Cancer Letters (Accept). 2021. 影响因子:8.679
- Nanoparticle Enhanced Combination Therapy for Stem-like Progenitors Defined by Single-Cell Transcriptomics in Chemotherapy-Resistant Osteosarcoma. Wang L, Huang X, You X, Yi T, Lu B, Liu J, Lu G, Ma M, Zou C, Wu J*, and Zhao W*. Signal Transduction and Targeted Therapy, 2020 Sep 25;5(1):196. 影响因子:18.187
- Interplay of m6A and H3K27 trimethylation restrains inflammation during bacterial infection. Wu C, Chen W, He J, Jin S, Liu Y, Yi Y, Gao Z, Yang J, Yang J*, Cui J*, and Zhao W*. Science Advances. 2020 Aug 19:Vol. 6, no. 34, eaba0647. 影响因子:14.163
- Targeting Super-Enhancers via Nanoparticle-facilitated BRD4 and CDK7 Inhibitors Synergistically Suppresses Pancreatic Ductal Adenocarcinoma. Huang CS, You X, Dai C, Xu QC, Li F, Wang L, Huang XT, Wang JQ, Li SJ, Gao Z, Wu J*, Yin XY*, and Zhao W*. Advanced Science. 2020 Feb 16;7(7):1902926. 影响因子:16.806
- Epigenetic Profiling Identifies LIF as a Super-enhancer-Controlled Regulator of Stem Cell-like Properties in Osteosarcoma. Lu B, He Y, He J, Wang L, Liu Z, Yang J, Gao Z, Lu G, Zou C*, Zhao W*. Mol Cancer Res. 2020 Jan;18(1):57-67. 影响因子:5.852
- MFAP5 facilitates the aggressiveness of intrahepatic Cholangiocarcinoma by activating the Notch1 signaling pathway.Li JH, Zhu XX, Li FX, Huang CS, Huang XT, Wang JQ, Gao ZX, Li SJ, Xu QC, Zhao W*, Yin XY*. J Exp Clin Cancer Res. 2019 Nov 27;38(1):476. 影响因子:11.161
- Isoform-specific involvement of Brpf1 in expansion of adult hematopoietic stem and progenitor cells. He Q, Hong M, He J, Chen W, Zhao M, Zhao W*. J Mol Cell Biol. 2019 Sep 30. 影响因子:6.216
- N6-methyladenosine Modulates Nonsense-mediated mRNA Decay in Human Glioblastoma. Li F, Yi Y, Miao Y, Long W, Long T, Chen S, Cheng W, Zou C, Zheng Y, Wu X, Ding J, Zhu K, Chen D, Xu Q, Wang J, Liu Q, Zhi F, Ren J, Cao Q*, Zhao W*. Cancer Res. 2019 Sep 17. 影响因子:12.701
科研项目
1. 国家自然科学基金面上项目,2020-2023,项目负责人
2. 国家自然科学基金面上项目,2018-2021,项目负责人
3.国家重点研发计划干细胞及转化研究项目,2017-2021,课题负责人
4. 国家自然科学基金面上项目,2016-2019,项目负责人 (已结题)