导师资格:博士生导师
所在教研室/单位: 生理学教研室
E-mail:[email protected]
通信地址: 广州中山二路74号何母楼808,科技楼东725
办公电话:020-87330028818
研究方向:病理性疼痛的发病机制及治疗
个人简介
2002年毕业于山东济宁医学院临床医学专业,2007年在中山大学获博士学位,自2014年1月至今任博彩公司排名 生理教研室副教授。2016.3-2017.3美国西北大学生理系访学一年。研究领域为病理性疼痛的发病机制,迄今为止发表了40 余篇相关论文。2014年入选广东省高等学校“千百十工程”校级培养对象。
学术成果
发表论文
- Han S, Jiang B, Ren J, Gao F, Wen J, Zhou T, Wang L, Wei X*. Impaired lactate release in dCA1 astrocytes contributed to nociceptive sensitization and comorbid memory deficits in rodents. Anesthesiology. 2023 Aug 31. doi: 10.1097/ALN.0000000000004756. (中科院大类一区top,IF: 8.9, 独立通讯作者)
- Han S, Ren J, Li Z, Wen J, Jiang B*, Wei X*. Deactivation of dorsal CA1 pyramidal neurons projecting to medial prefrontal cortex contributes to neuropathic pain and short-term memory impairment. Pain. 2023 Oct 27. doi: 10.1097/j.pain.0000000000003100. (中科院大类一区top,IF: 7.4,末位通讯作者)
- Wu Y, Qiu Y, Su M, Wang L, Gong Q, Wei X*. Activation of the bile acid receptors TGR5 and FXR in the spinal dorsal horn alleviates neuropathic pain. CNS Neurosci Ther. 2023; 29(7):1981-1998. (中科院大类一区top,IF: 7.0,末位通讯作者)
- Wei X, Centeno M, Ren W, Borruto A, Procissi D, Xu T, Jabakhanji R, Mao Z, Haram Kim, Li Y, Yang Y, Gutruf P, Rogers J, Surmeier D, Radulovic J, Liu X, Martina M, Apkarian A. Activation of the dorsal, but not ventral, hippocampus relieves neuropathic pain in rodents. Pain. 2021;162(12):2865-2880. (中科院大类一区top,IF: 7.8)
- Xu J, Wei X, Gao F, Zhong X, Guo R, Ji Y, Zhou X, Chen J, Yao P, Liu X, Wei X. NADPH oxidase 2 derived ROS contributes to LTP of C-fiber evoked field potentials in spinal dorsal horn and persistent mirror-image pain following high frequency stimulus of the sciatic nerve. Pain. 2020; 161(4):758-772. (中科院大类一区top,IF: 7.8,独立通讯作者)
- Wang W, Zhong X, Li Y, Guo R, Du S, Wen L, Ying Y, Yang T, Wei XH. Rostral ventromedial medulla-mediated descending facilitation following P2X7 receptor activation is involved in the development of chronic post-operative pain. J Neurochem. 2019 149(6):760-780. (中科院大类二区top,IF: 4.8,独立通讯作者)
- Yang T, Du S, Liu X, Ye X, Wei X. Withdrawal from spinal application of remifentanil induces long-term potentiation of c-fiber-evoked field potentials by activation of Src family kinases in spinal microglia. Neurochem Res. 2018; 43(8):1660-1670. (中科院大类三区,IF: 4.0,末位通讯作者)
- Song J, Ying Y, Wang W, Liu X, Xu X*, Wei X*, Ruan X* (2017) The role of P2X7R/ERK signaling in dorsal root ganglia satellite glial cells in the development of chronic postsurgical pain induced by skin/muscle incision and retraction (SMIR). Brain, behavior, and immunity.(中科院大类一区,IF: 19.8, 并列通讯作者).
- Xu J, Feng YW, Liu L, Wang W, Zhong XX, Wei XH*, Liu XG (2017) Liver X Receptor alpha Is Involved in Counteracting Mechanical Allodynia by Inhibiting Neuroinflammation in the Spinal Dorsal Horn. Anesthesiology. 127:534-547. (中科院大类一区,IF:8.9,独立通讯作者).
- Xu J, Wang W, Zhong XX, Feng Y, Wei X*, Liu XG* (2016) EXPRESS: Methylcobalamin ameliorates neuropathic pain induced by vincristine in rats: Effect on loss of peripheral nerve fibers and imbalance of cytokines in the spinal dorsal horn. Molecular pain. 12 ( IF:3.0, 并列通讯作者).
- Chen SL, Zang Y, Zheng WH, Wei XH, Liu XG (2016) Inhibition of Neuropathic Pain by a Single Intraperitoneal Injection of Diazepam in the Rat: Possible Role of Neurosteroids. The Chinese journal of physiology. 59:9-20 (IF:1.2, 独立通讯作者).
- Zhu HQ, Xu J, Shen KF, Pang RP, Wei X*, Liu XG* (2015) Bulleyaconitine A depresses neuropathic pain and potentiation at C-fiber synapses in spinal dorsal horn induced by paclitaxel in rats. Exp. Neurol. 273:263-272 (IF:4.7,并列通讯作者).
- Ying YL#, Wei XH#, Xu XB, She SZ, Zhou LJ, Lv J, Li D, Zheng B, Liu XG. Over-expression of P2X7 receptors in spinal glial cells contributes to the development of chronic postsurgical pain induced by skin/muscle incision and retraction (SMIR) in rats. Exp. Neurol. 261, 836-843, 2014 (IF:4.6,并列第一作者)
- Wei XH, Wei X, Chen FY, Zang Y, Xin WJ, Pang RP, Chen Y, Wang J, Li YY, Shen KF, Zhou LJ, Liu XG*. The Upregulation of Translocator Protein (18 kDa) Promotes Recovery from Neuropathic Pain in Rats. J. Neurosci. 33(4),1540-1551, 2013 (IF:6.8)
- Wei XH, Na XD, Liao GJ, Chen QY, Cui Y, Chen FY, Li YY, Zang Y, Liu XG*. The up-regulation of IL-6 in DRG and spinal dorsal horn contributes to neuropathic pain following L5 ventral root transection. Exp. Neurol. 241,159-68, 2013 (IF:4.6)
- Li YY #, Wei XH #, Lu ZH, Chen JS, Huang QD, Gong QJ*. Src/p38 MAPK pathway in spinal microglia is involved in mechanical allodynia induced by peri-sciatic administration of recombinant rat TNF-α. Brain Res Bull. 96, 54-61, 2013. (IF:3.3,共同第一作者))
- Wei XH, Yang Tao, Wu Qiang, Xin WJ, Zang Y, Wu JL, Wang YQ, Wang Jun, Li YY and Liu XG. Peri-sciatic administration of recombinant rat IL-1<beta> induces mechanical allodynia by activation of src-family kinases in spinal microglia in rats. Exp. Neurol. 2012; 241:159-68. (IF:4.6)
- Wei XH, Zang Y, Wu CY, Xu JT, Xin WJ and Liu XG. Peri-sciatic administration of recombinant rat TNF-α induces mechanical allodynia via up-regulation of TNF-α in dorsal root ganglia and in spinal dorsal horn: the role of NF-kappa B pathway. Exp. Neurol. 2007; 205(2): 471-484. (IF:4.6)
- He XH, Zang Y, Chen X, Pang RP, Xu JT, Zhou X, Wei XH, Li YY, Xin WJ, Qin ZH, Liu XG. TNF-α contributes to up-regulation of Nav1.3 and Nav1.8 in DRG neurons following motor fiber injury. Pain 2010; 151(2): 266-279. (IF:6.0)
- Ren WJ, Liu Y, Zhou LJ, Li W, Zhong Y, Pang RP, Xin WJ, Wei XH, Wang J, Zhu HQ, Wu CY, Qin ZH, Liu G, Liu XG. Peripheral nerve injury leads to working memory deficits and dysfunction of the hippocampus by upregulation of TNF-alpha in rodents. Neuropsychopharmacology 2011; 36(5) 979-992. (IF:7.8)
- Shen KF, Zhu HQ, Wei XH, Wang J, Li YY, Pang RP, Liu XG*. Interleukin-10 down-regulates voltage gated sodium channels in rat dorsal root ganglion neurons. Exp. Neurol. 247, 466-475, 2013.
- Wang J, Liu Y, Zhou LJ, Wu Y, Li F, Shen KF, Pang RP, Wei XH, Li YY, Liu XG*. Magnesium L-threonate prevents and restores memory deficits associated with neuropathic pain by inhibition of TNF-α. Pain Physician. 16(5): E563-E575, 2013
- 代娟丽, 王臻, 董超雄, 李玉莹, 魏绪红*. RVM致炎细胞因子上调导致5-HT释放参与调控慢性术后疼痛. 中山大学学报 2024,网络首发
- 黄睿臻, 徐劲, 魏绪红. 弥可保预防长春新碱诱导的病理性疼痛的机制. 中山大学学报(医学科学版). 2022, 43(02), 212-220
- 魏绪红, 臧颖, 王静, 信文君, 宫庆娟, 张彤, 李永勇, 刘先国. 坐骨神经周围给予rrTNF引起病理性疼痛. 中国病理生理杂志 2009, 25(4), 719-724
- 魏绪红,杨涛, 宫庆娟, 信文君, 周丽君, 刘先国. 大鼠脊髓小胶 质细胞p38 MAPK介导rrIL-1β诱导的机械痛敏. 中山大学学报2010,31(3):327-331
科研项目
- 增强背侧海马锥体神经元兴奋抑制外周神经损伤引起的神经病理性疼痛的作用及其机制研究(No.81870969)国家自然科学基金面上项目,56万,2019.1~2022.12 负责人
- 脊髓背角肝X受体抑制致炎细胞因子表达促进神经病理性疼痛恢复的作用及其机制(No. 81471250)国家自然科学基金面上项目,70万,2015.1~2018.12 负责人
- 胶质细胞TSPO抗神经病理性疼痛的机制(No. 81200856)国家自然科学青年基金 32万,2013.1~2015.12 负责人
- 背侧海马星形胶质细胞源性乳酸对外周神经损伤引起的记忆障碍的作用及其机制(2019A1515011855). 广东省自然科学基金面上项目10万2019.10~2022.09负责人
- L-苏糖酸镁对化疗药物引起的神经病理性疼痛的预防作用及其机制,广东省科技计划项目10万,2016A020215035, 2016.1~2018.12负责人
- 脊髓背角肝X受体对神经病理性疼痛的调制作用及其机制(No. 13ykpy05)青年教师培育项目, 15万, 2014.1~2016.12负责人
- DRG LXRs 抑制外周敏感化促进神经病理性疼痛恢复的作用及其机制.广东省自然科学基金面上项目,10万,2015.1~2017.12负责人
- TSPO激动剂抑制神经病理性疼痛的作用及其机制(No:20100171120053)教育部新教师基金,3.6万, 2011.1~2013.12负责人
获奖荣誉
2023年广东省柯麟医学教育基金会临床医学专业优秀中青年教师奖,
2023年中国生理学会全国高等学校人体生理学教师教学大赛三等奖,
2023-2024学年第一学期博彩公司排名
本科课程教案大赛优秀奖,
2023年中山大学第十一届教学成果二等奖 (第八),
2020-2022年 博彩公司排名
优秀共产党员,
2012年中华医学科技奖二等奖 (第五),
2014年博彩公司排名
学术节二等奖,
中国生理学会张锡钧基金会第十届青年优秀生理学学术论文最佳答辩奖,
2011年广东省生理学会优秀论文报告三等奖,
第三届博彩公司排名
学术节青年学术奖三等奖
学术兼职
本科毕业论文(设计)抽检专家库专家
Fronties in pain research 副主编
教育部学位论文评审专家
广东省神经科学学会理事,党支部副书记
中国神经科学学会会员
中国生理学会会员
广东省神经科学学会理事、党支部副书记