导师资格：博士生导师

所在教研室/单位： 生物化学与分子生物学教研室

E-mail：[email protected]

研究方向：以卵巢癌为主要疾病模型，研究细胞代谢与细胞周期检查点在DNA复制压力(DNA replication stress)调控中的关键作用，进而解析基因毒性药物（genotoxic drug）的化疗抵抗机制与逆转策略。

个人简介

    潘超云，博彩公司排名-博彩公司评级 副教授，博士生导师，课题组PI，中山大学“百人计划”引进人才，中山大学逸仙学者。2016年博士毕业于南京大学；2016年至2020年在美国埃默里大学医学院从事博士后研究；2020年起任职于博彩公司排名-博彩公司评级 生物化学与分子生物学系。

    课题组以卵巢癌为主要疾病模型，研究细胞代谢与细胞周期检查点在DNA复制压力(DNA replication stress)调控中的关键作用，进而解析基因毒性药物（genotoxic drug）的化疗抵抗机制与逆转策略。

    课题组研究成果以第一作者或者通讯作者发表在Cell Metabolism，JCI (3篇), Nature Communications, Molecular Cell, Nature Microbiology, Clinical Cancer Research, PLoS Pathogen, Oncogene等领域高水平杂志，并获得国家自然科学基金面上项目与青年项目、科技部“生育健康及妇女儿童健康保障”重点专项、重点研发计划“合成生物学”青年科学家项目、广东省自然科学基金面上项目、中山大学创新人才培育项目、以及美国癌症研究协会AACR Fellowship等基金资助 （更新至：2023年12月20日）。

    本实验室长期招聘博士后，并招收博士及硕士研究生(分子医学)。有意者欢迎与潘超云博士联系：[email protected], 热烈欢迎加入我们！

 

学术成果

代表性学术论著

  1. Li Jie, Zheng Cuimiao, Mai Qiuwen, Huang Xi, Pan Wenfeng, Lu Jingyi, Chen Zhengfan, Zhang Suman, Zhang Chunyu, Huang Hua, Chen Yangyang, Guo Hongbo, Wu Zhenyin, Deng Chunnuan, Jiang Yiting, Li Bo, Liu Junxiu, Yao Shuzhong, Pan Chaoyun. Tyrosine catabolism enhances genotoxic chemotherapy by suppressing translesion DNA synthesis in epithelial ovarian cancer. Cell Metabolism 2023, 35(11). (最后通讯)
  2. Li Jie, Lu Jingyi, Xu Manman, Yang Shiyu, Yu Tiantian, Zheng Cuimiao, Huang Xi, Pan Yuwen, Chen Yangyang, Long Juming, Zhang Chunyu, Huang Hua, Dai Qingyuan, Li Bo, Wang Wei, Yao Shuzhong, Pan Chaoyun. ODF2L acts as a synthetic lethal partner with WEE1 inhibition in epithelial ovarian cancer models. J Clin Invest 2023, 133(2). (最后通讯)
  3. Li Jie, Zheng Cuimiao, Wang Mingshuo, Umano Anna D, Dai Qingyuan, Zhang Chunyu, Huang Hua, Yang Qing, Yang Xianzhi, Lu Jingyi, Pan Wenfeng, Li Bo, Yao Shuzhong, Pan Chaoyun. ROS-regulated phosphorylation of ITPKB by CAMK2G drives cisplatin resistance in ovarian cancer. Oncogene 2022, 41(8): 1114-1128. (最后通讯)
  4. Pan Chaoyun, Li Bo, Simon M Celeste. Moonlighting functions of metabolic enzymes and metabolites in cancer. Mol Cell 2021, 81(18): 3760-3774. (综述类文章)
  5. Pan Chaoyun, Kang JiHoon, Hwang Jung Seok, Li Jie, Boese Austin C, Wang Xu, Yang Likun, Boggon Titus J, Chen Georgia Z, Saba Nabil F, Shin Dong M, Magliocca Kelly R, Jin Lingtao, Kang Sumin. Cisplatin-mediated activation of glucocorticoid receptor induces platinum resistance via MAST1. Nat Commun 2021, 12(1): 4960. (第一作者)
  6. Liu Zhijun, You Yuyu, Chen Qiyi, Li Guobang, Pan Wenfeng, Yang Qing, Dong Jiajun, Wu Yi, Bei Jin-Xin, Pan Chaoyun#, Li Fuming#, Li Bo#. Extracellular vesicle-mediated communication between hepatocytes and natural killer cells promotes hepatocellular tumorigenesis. Mol Ther 2021. (#共同通讯作者)
  7. Pan Chaoyun, Jin Lingtao, Wang Xu, Li Yuancheng, Chun Jaemoo, Boese Austin C, Li Dan, Kang Hee-Bum, Zhang Guojing, Zhou Lu, Chen Georgia Z, Saba Nabil F, Shin Dong M, Magliocca Kelly R, Owonikoko Taofeek K, Mao Hui, Lonial Sagar, Kang Sumin. Inositol-triphosphate 3-kinase B confers cisplatin resistance by regulating NOX4-dependent redox balance. J Clin Invest 2019, 129(6): 2431-2445. (第一作者)
  8. Pan Chaoyun*, Chun Jaemoo*, Li Dan, Boese Austin C, Li Jie, Kang JiHoon, Umano Anna, Jiang Yunhan, Song Lina, Magliocca Kelly R, Chen Zhuo G, Saba Nabil F, Shin Dong M, Owonikoko Taofeek K, Lonial Sagar, Jin Lingtao, Kang Sumin. Hsp90B enhances MAST1-mediated cisplatin resistance by protecting MAST1 from proteosomal degradation. J Clin Invest 2019, 129(10): 4110-4123. (*共同第一作者)
  9. Zhu Dihan*, Pan Chaoyun*, Sheng Jingxue*, Liang Hongwei*, Bian Zhen, Liu Yuan, Trang Phong, Wu Jianguo, Liu Fenyong, Zhang Chen-Yu, Zen Ke. Human cytomegalovirus reprogrammes haematopoietic progenitor cells into immunosuppressive monocytes to achieve latency. Nat Microbiol 2018, 3(4): 503-513. (*共同第一作者)
  10. Pan Chaoyun*, Zhu Dihan*, Wang Yan*, Li Limin, Li Donghai, Liu Fenyong, Zhang Chen-Yu, Zen Ke. Human Cytomegalovirus miR-UL148D Facilitates Latent Viral Infection by Targeting Host Cell Immediate Early Response Gene 5. PLoS Pathog 2016, 12(11): e1006007. (*共同第一作者)
  11. Zhu Dihan*, Pan Chaoyun*, Li Limin, Bian Zhen, Lv Zhiyuan, Shi Lei, Zhang Jing, Li Donghai, Gu Hongwei, Zhang Chen-Yu, Liu Yuan, Zen Ke. MicroRNA-17/20a/106a modulate macrophage inflammatory responses through targeting signal-regulatory protein alpha. J Allergy Clin Immunol 2013, 132(2): 426-436 e428.(*共同第一作者)