博彩公司排名

个人简历

2021-今，副教授，博彩公司排名 ，中山大学

2019-2021：特聘研究员，中山大学

2016-2019：特聘副研究员，中山大学

2011-2016：博士研究生，药理学专业，中山大学

研究方向

为溶瘤病毒，专注溶瘤病毒的肿瘤靶向性分子机制、免疫学特性和新毒种研究。在本领域内以第一或通讯作者在Nature Communications，PNAS, Oncogene，Molecular Oncology等国际期刊上发表了10项研究成果，阐明了溶瘤病毒M1天然靶向肿瘤细胞的分子机制，并基于M1病毒和肿瘤细胞的相互作用，发现系列增效靶点。作为项目负责人共主持国家、省、市和学校项目共6项，包括国家自然科学基金3项、广东省自然科学基金和广州市民生科技攻关项目等，并在2021年获得广东省自然科学基金杰出青年项目资助。

学术成果

学术论著

1. Liang J, Guo L, Li K, Xiao X, Zhu W, Zheng X, Hu J, Zhang H, Cai J, Yu Y, Tan Y, Li C, Liu X, Hu C, Liu Y, Qiu P, Su X, He S, Lin Y, Yan G (2018) Inhibition of the mevalonate pathway enhances cancer cell oncolysis mediated by M1 virus. Nature communications 9(1):1524
2. Xiao X, Liang J (co-first author), Huang C, Li K, Xing F, Zhu W, Lin Z, Xu W, Wu G, Zhang J, Lin X, Tan Y, Cai J, Hu J, Chen X, Huang Y, Qin Z, Qiu P, Su X, Chen L, Lin Y, Zhang H, Yan G (2018) DNA-PK inhibition synergizes with oncolytic virus M1 by inhibiting antiviral response and potentiating DNA damage. Nature communications 9(1):4342
3. Cai J, Liu W, Wong CW, Zhu W, Lin Y, Hu J, Xu W, Zhang J, Sander M, Wang Z, Dan J, Zhang J, Liu Y, Guo L, Qin Z, Liu X, Liu Y, Yan G, Wu S, Liang J (corresponding author) (2020) Zinc-finger antiviral protein acts as a tumor suppressor in colorectal cancer. Oncogene 39(37):5995-6008
4. Cai J, Lin K, Cai W, Lin Y, Liu X, Guo L, Zhang J, Xu W, Lin Z, Wong CW, Sander M, Hu J, Yan G, Zhu W, Liang J (corresponding author) (2020) Tumors driven by RAS signaling harbor a natural vulnerability to oncolytic virus M1. Molecular oncology 14(12):3153-3168
5. Liu Y, Cai J, Liu W, Lin Y, Guo L, Liu X, Qin Z, Xu C, Zhang Y, Su X, Deng K, Yan G, Liang J (corresponding author) (2020) Intravenous injection of the oncolytic virus M1 awakens antitumor T cells and overcomes resistance to checkpoint blockade. Cell death & disease 11(12):1062
6. Cai J, Zhu W, Lin Y, Zhang S, Chen X, Gong S, He S, Hu J, Yan G, Liang J (corresponding author) (2020) Systematic Characterization of the Biodistribution of the Oncolytic Virus M1. Human gene therapy 31(21-22):1203-1213
7. Lin Y, Zhang HP, Liang JK(co-first author), Li K, Zhu WB, Fu LW, Wang F, Zheng XK, Shi HJ, Wu SH, Xiao X, Chen LJ, Tang LP, Yan M, Yang XX, Tan YQ, Qiu PX, Huang YJ, Yin W, Su XW, Hu HY, Hu J, Yan GM (2014) Identification and characterization of alphavirus M1 as a selective oncolytic virus targeting ZAP-defective human cancers. P Natl Acad Sci USA 111(42):E4504-E4512
8. Dan J, Nie L, Jia X, Xu C, Cai J, Lin Y, Hu J, Zhu W, Li Y, Chen D, Liu Y, Hu C, Yan G, Liang J (co-corresponding author), Zhang Q (2021) Visualization of the Oncolytic Alphavirus M1 Life Cycle in Cancer Cells. Virologica Sinica
9. Liu Y, Li K, Zhu WB, Zhang H, Huang WT, Liu XC, Lin Y, Cai J, Yan GM, Qiu JG, Peng L, Liang JK (co-corresponding author), Hu C (2021) Suppression of CCDC6 sensitizes tumor to oncolytic virus M1. Neoplasia 23(1):158-168
10. Cai J, Zhu W, Lin Y, Hu J, Liu X, Xu W, Liu Y, Hu C, He S, Gong S, Yan G, Liang J (corresponding author) (2020) Lonidamine potentiates the oncolytic efficiency of M1 virus independent of hexokinase 2 but via inhibition of antiviral immunity. Cancer cell international 20(1):532