个人简介

博彩公司排名 副教授,斯坦福大学霍华德.休斯医学研究所(HHMI)访问学者。2005年6月本科毕业于博彩公司排名-博彩公司评级 法医学系,获“中山大学优秀毕业生”称号,并获免试研究生资格,于2005年9月在博彩公司排名-博彩公司评级 免试攻读研究生, 从事脑卒中离子通道学研究,2010年6月毕业, 获医学博士学位。2010年7月留校任教, 在博彩公司排名 法医学系任讲师, 2013年获评硕士研究生导师,后晋升为副教授,在国家级司法鉴定机构“中山大学法医鉴定中心”任鉴定专家。主要致力于精神损伤神经生物学机制研究,已发表SCI论文20篇(IF>5的有5篇),其中通讯作者或共同通讯作者7篇,第一或共同第一作者5篇,主持国家自然科学基金等科研项目5项,获2013年博彩公司排名-博彩公司评级 青年学术奖一等奖,2013年教育部自然科学二等奖和2014年度中华医学科技奖二等奖(第6完成人)。

学术成果

Acting Grants:

  1. 2014~2017 Role of ClC-3 in hydrogen peroxide-induced mitophagy in artery smooth muscle cells. National Natural Science Foundation of China, 230,000 RMB, Principal Investigator (Number: 81300106)
  2. 2013~2017 Mechanism of ClC-3 in regulating hypertensive cerebrovascular remodeling. Provincial Natural Science Fund Project of Guangdong, 30,000 RMB, Principal Investigator (Number: S2012040006519)
  3. 2012~2015 Mechanism of ClC-3 chloride channels in regulating hypertensive cardiac hypertrophy induced by Angiotension-Ⅱ in mice. Fundamental Research Funds for the Central Universities, 150,000 RMB, Principal Investigator (Number: 11YKPY06)

 

Representative Publications:

  1. Wang, Xiao-Guang#,Tao, Jing#,Ma, Ming-Ming#,Tang, Yong-Bo,Zhou, Jia-Guo,Guan, Yong-Yuan*,Tyrosine 284 phosphorylation is required for ClC-3 chloride channel activation in vascular smooth muscle cells,Cardiovasc Res,,2013,98(3):469-478(Impact factor:6.02)
  2. Asim M, Wang B, Hao B, Wang XG*. Ketamine for post-traumatic stress disorders and it's possible therapeutic mechanism. Review. Neurochem Int. 2021;146:105044. doi: 10.1016/j.neuint.2021.105044. (Impact factor:3.88)
  3. Chen YF#, Chen ZX#, Wang RH, Shi YW, Xue L, Wang XG*, Zhao H*. Knockdown of CLC-3 in the hippocampal CA1 impairs contextual fear memory. Prog Neuropsychopharmacol Biol Psychiatry. 2019;89:132-145. (Impact factor:4.36)
  4. Asim M#, Hao B#, Yang YH, Fan BF, Xue L, Shi YW*, Wang XG*, Zhao H. Ketamine Alleviates Fear Generalization Through GluN2B-BDNF Signaling in Mice. Neurosci Bull. 2020 Feb;36(2):153-164. (Impact factor:4.32)
  5. Liu, Yu-Jie#,Wang, Xiao-Guang#,Tang, Yong-Bo#,Chen, Jing-Hui,Lv, Xiao-Fei,Zhou, Jia-Guo*,Guan,Yong-Yuan*,Simvastatin Ameliorates Rat Cerebrovascular Remodeling During Hypertension via Inhibition of Volume-Regulated Chloride Channel,HYPERTENSION,2010,56(3):445-452(Impact factor:6.93)
  6. Zeng, Jia-Wei#, Wang, Xiao-Guang#,Ma, Ming-Ming#,Lv, Xiao-Fei,Liu, Jie,Zhou, Jia-Guo,Guan,Yong-Yuan*,Integrin beta3 mediates cerebrovascular remodelling through Src/ClC-3 volume-regulated Cl- channel signalling pathway.,Br J Pharmacol,,2014,171(13):3158-3170(Impact factor:5.04)
  7. Fang Liu#,Qing-Hua Cao#,De-Jian Lu#,Bin Luo,Xiao-Fang Lu,Rong-Cheng Luo*,Xiao-Guang Wang*,TMEM16A overexpression contributes to tumor invasion and poor prognosis of human gastric cancer through TGF-βsignaling,Oncotarget,2015,Feb.Epub ahead of print. (Impact factor:6.61)
  8. Shi YW#, Fan BF, Xue L, Wang XG*, Ou XL*. Fear renewal activates cyclic adenosine monophosphate signaling in the dentate gyrus.Brain Behav. 2019;9(8):e01280.(Impact factor:2.09)
  9. Tong ZT#, Cai MY#, Wang XG, Kong LL, Mai SJ, Liu YH, Zhang HB, Liao YJ, Zheng F,Zhu W, Liu TH, Bian XW, Guan XY, Lin MC, Zeng MS, Zeng YX, Kung HF, Xie D.EZH2 supports nasopharyngeal carcinoma aggressiveness by forming a co-repressor complex with HDAC1/HDAC2 and Snail to inhibit E-cadherin. Oncogene. 2012 Feb;31:583-94(Impact factor:7.36)
  10. Li, Shi-Yang#,Wang, Xiao-Guang#,Ma, Ming-Ming,Liu, Yun,Du, Yan-Hua,Lv, Xiao-Fei,Zhou,Jia-Guo,Tang, Yong-Bo*,Guan, Yong-Yuan*,Ginsenoside-Rd potentiates apoptosis induced by hydrogen peroxide in basilar artery smooth muscle cells through the mitochondrial pathway,Apoptosis,2012,17(2):113-120(Impact factor:4.32)