导师资格：硕士生导师

所在教研室/单位： 微生物学教研室

E-mail：[email protected]

研究方向：RNA病毒与宿主相互作用的分子机理研究

个人简介

2009年06月获中山大学微生物学博士学位；2009年07月至今，在博彩公司排名-博彩公司评级 从事RNA病毒（ZIKV/DENV/HIV-1）与宿主互作的分子机理研究，在宿主因子尤其是脂代谢相关因子调控病毒复制的分子机理等研究领域取得了一系列重要的研究成果，并作为通讯作者（共同通讯作者）和第一作者在Journal of Virology、Journal of Biological Chemistry、Virology、Retrovirology、Frontiers in Microbiology、Frontiers in Cellular and Infection Microbiology和BMC Medicine等病毒学权威期刊上发表SCI论文十余篇。近年来，共主持国家自然科学基金2项，广东省自然科学基金2项，广东省省级科技计划项目1项，广东省创新团队子课题1项，高等学校博士点专项基金1项以及中国博士后科学基金1项，并于2016年入选广东省特支计划百千万工程青年拔尖人才。

学术成果

学术论著与教材

  1. Wang Y, Huo ZT, Lin QS, Lin YX, Chen CC, Huang YX, Huang CB, Zhang JS, He JF, Liu C*, Zhang P*. Positive Feedback Loop of Long Noncoding RNA OASL-IT1 and Innate Immune Response Restricts the Replication of Zika Virus in Epithelial A549 Cells. Journal of Innate Immunity. 2021. 13(3):179-193.
  2. Huang YX#, Lin QS#, Huo ZT, Chen CC, Zhou SL, Ma XC, Gao HX, Lin YX, Li XB, He JF, Zhang P*, Liu C*. Inositol-Requiring Enzyme 1 alpha Promotes Zika Virus Infection through Regulation of Stearoyl Coenzyme A Desaturase 1-Mediated Lipid Metabolism. Journal of Virology. 2020. 94(23):e01229-20.
  3. Ma XC, Luo X, Zhou SL, Huang YX, Chen CC, Huang CB, Shen L, Zhang P, and Liu C*. Hydroxycarboxylic Acid Receptor 2 Is a Zika Virus Restriction Factor That Can Be Induced by Zika Virus Infection Through the IRE1-XBP1 Pathway. Frontiers in Cellular and Infection Microbiology. 2020. 9: 480.
  4. Lin QS#, Zhou SL#, Huang YX, Huo ZT, Chen CC, Luo X, He JF, Liu C*,  Zhang P*. ANKS4B Restricts Replication of Zika Virus by Downregulating the Autophagy. Frontiers in Microbiology. 2020. 11: 1745.
  5. Zhou SL, Yang C, Zhao FF, Huang YX, Lin YX, Huang CB, Ma XC, Du JJ, Wang Y, Long G, He JF, Liu C*, and Zhang P*. Double-stranded RNA deaminase ADAR1 promotes the Zika virus replication by inhibiting the activation of protein kinase PKR. J Biol Chem. 2019. 294(48) : 18168-18180.
  6. Gao HX#, Lin YX#, He JF, Zhou SL, Liang MJ, Huang CB, Li XB, Liu C*, and Zhang P*. Role of heparan sulfate in the Zika virus entry, replication, and cell death. Virology. 2019. 529: 91-100.
  7. Chen CC, Ma XC, Hu QF, Li XH, Huang F, Zhang JS, Pan T, Xia JY, Liu C*, and Zhang H. Moloney leukemia virus 10 (MOV10) inhibits the degradation of APOBEC3G through interference with the Vif-mediated ubiquitin–proteasome pathway. Retrovirology. 2017. 14: 56.
  8. Liu C, Ma XC, Liu BF, Chen CC, Zhang H*. HIV-1 functional cure: will the dream come true? BMC Medicine. 2015. 13: 284.
  9. Huang F#, Zhang JS#, Zhang YJ, Geng GN, Liang JR, Li YN, Chen JL, Liu C*, and Zhang H. RNA helicase MOV10 functions as a co-factor of HIV-1 Rev to facilitate Rev/RRE-dependent nuclear export of viral mRNAs. Virology. 2015. 486:15-26.
  10. Yin Y, Zhang SY, Luo HH, Zhang X, Geng GN, Li J, Guo XM, Cai WP, Li LH, Liu C*, and Zhang H*. Interleukin 7 up-regulates CD95 protein on CD4+ T cells by affecting mRNA alternative splicing: priming for a synergistic effect on HIV-1 reservoir maintenance. J Biol Chem. 2015. 290(1):35-45.
  11. Zhou XX#, Luo J#, Mills L#, Wu SX, Pan T, Geng GN, Zhang J, Luo HH, Liu C*, and Zhang H*. DDX5 facilitates HIV-1 replication as a cellular co-factor of Rev. PLoS ONE. 2013. 8(5): e65040.
  12. Liu C*, Zhang X, Huang F, Yang B, Li J, Liu BF, Luo HH, Zhang P, and Zhang H*. APOBEC3G Inhibits microRNA-mediated repression of translation by interfering with the interaction between argonaute-2 and MOV10. J Biol Chem. 2012. 287: 29373-29383.