导师资格：博士生导师

所在教研室/单位： 人体解剖学教研室

E-mail：[email protected]

通信地址： 中山二路74号博彩公司排名-博彩公司评级

研究方向：成体干细胞移植与组织再生修复

个人简介

 姜美花，博彩公司排名-博彩公司评级 教授、博士生导师、硕士生导师。广东省医学会细胞治疗学分会委员，青年委员会副主任委员、中国解剖学会会员、广东省解剖学学会会员。2010毕业于韩国庆熙大学，师从韩国著名干细胞专家Youngsook Son, 获博士学位, 2010年加入博彩公司排名-博彩公司评级 任职至今。

主要从事成体干细胞移植与组织再生修复相关机制研究，在Nature Medicine、Cell Rescerch、Biomaterials、Journal of Neuroscience、Stem Cells等学术期刊发表论文20余篇，引用900余次。主要学术贡献为：1）证实了动员内源性神经干细胞，骨髓间质干细胞参与损伤修复的调控机制；2）轴突的靶向延伸及神经再生机制研究；3）利用成体干细胞标志物Nestin分离并鉴定出心脏、肾、睾丸间质干细胞，证实其在组织再生修复中的作用及机制，以及在衰老过程中的作用，为揭示组织干细胞的发育起源，以及临床转化应用提供了重要的科学依据。主持国家自然科学基金2项、广州市民生科技计划项目、广东省科技计划项目等；作为骨干参与国家重点研发计划，国家自然科学基金重点项目、广东省重大科技专项、国家重大研究计划/重点支持项目等，研究经费超过1000万元，获得授权专利3项，申请PCT专利2项。参与医用解剖学，格式解剖学等教材的编写。

学术成果

  1. Xie D, Liao Y, Wu B, Chen Y, Lin W, Lu D, Gao S, Zhu S, Peng C, Jiang MH*.Cardiac Nestin+ cells derived from early stage of dilated cardiomyopathy enhanced the survival of the doxorubicin-injured cardiac muscle HL-1 cells. Int Heart J. 2018，59(1):180-189. IF:1.826
  2. Zang ZJ, Fang YQ, Ji SY, Gao Y, Zhu YQ, Xia TT, Jiang MH, Zhang YN.Formaldehyde Inhibits Sexual Behavior and Expression of Steroidogenic Enzymes in the Testes of Mice. J Sex Med. 2017，14(11):1297-1306. IF:3.339
  3. Yang L＃, Li G, Ye J, Lu D, Chen Z, Xiang AP, Jiang MH*. Substance P enhances endogenous neurogenesis to improve functional recovery after spinal cord injury. Int J Biochem Cell Biology. 2017, 1; 89:110-119. IF: 3.247
  4. Zhang M＃, Jiang MH＃, Kim DW, Ahn W, Chung E, Son Y, Chi G. Comparative Analysis of the Cell Fates of Induced Schwann Cells from Subcutaneous Fat Tissue and Naïve Schwann Cells in the Sciatic Nerve Injury Model.Biomed Res Int. 2017, 2017:1252851. IF: 2.476
  5. Zang ZJ＃, Wang J＃, Chen Z＃, Zhang Y＃, Gao Y, Su Z, Tuo Y, Liao Y, Zhang M, Yuan Q, Deng C, Jiang MH*, Xiang AP*.Transplantation of CD51+ stem Leydig cells: A new strategy for the treatment of testosterone deficiency. Stem cells2017, 35(5):1222-1232. IF: 5.902
  6. Zang Z＃, Li S, Lin Y, Li X, Li Y, Qin Y, Wang H, Jiang MH*, Zhu L＊. Pentoxifylline Prevents Driamycin-Induced Myocardial Fibrosis and Apoptosis in Rats.Int Heart J. 2015, 2;56(6):651-5   IF:1.826
  7. Jiang MH#, Li G#, Liu J#, Liu L, Wu B, Huang W, He W, Deng C, Wang D, Li C, Lahn BT, Shi C*, Xiang AP*.Nestin(+) kidney resident mesenchymal stem cells for the treatment of acute kidney ischemia injury. Biomaterials. 2015, 50:56-66. IF：8.806
  8. Li WQ#, Huang LH#, Lin WY#, Ke Q, Chen R, Lai XQ, Wang XY, Zhang JF, Jiang MH, Huang WJ, Wang T, Yang XS, Chen Y, Song W*, Xiang AP*. Engraftable neural crest stem cells derived from cynomolgus monkey embryonic stem cells. Biomaterials, 2015, Jan;39:75-84. IF：8.806
  9. Jiang MH#, Cai B#, Tuo Y#, Wang J, Zang ZJ, Tu X, Gao Y, Su Z, Li W, Li G, Zhang M, Jiao J, Wan Z, Deng C, Lahn BT, Xiang AP*.Characterization of Nestin-positive stem Leydig cells as a potential source for the treatment of testicular Leydig cell dysfunctionCell Res. 2014, 24(12):1466-85. IF:15.393
  10. Tang S#, Zhu J#, Xu Y, Xiang AP, Jiang MH*, Quan D*.The effects of gradients of nerve growth factor immobilized PCLA scaffolds on neurite outgrowth in vitro and peripheral nerve regeneration in rats.Biomaterials. 2013, 34(29):7086-9. IF:8.806
  11. Jiang MH#, Lim JE, Chi GF, Ahn W, Zhang M, Chung E*, Son Y*. Substance P reduces apoptotic cell death possibly by modulating the immune response at the early stage after spinal cord injury. Neuroreport. 2013, 24(15):846-51.IF:1.266
  12. Jiang MH#, Chung E#, Chi GF, Ahn W, Lim JE, Hong HS, Kim DW, Choi H, Kim J, Son Y*. Substance P induces M2-type macrophages after spinal cord injury.Neuroreport.2012, 23(13):786-92. IF: 1.266
  13. Kang J#,Jiang MH, Min HJ, Jo EK, Lee S, Karin M, Yune TY, Lee SJ*. IKK-β-mediated myeloid cell activation exacerbates inflammation and inhibits recovery after spinal cord injury. Eur J Immunol , 2011, 41(5) : 1266-77. IF: 4.248
  14. Chi GF#, Kim MR, Kim DW, Jiang MH, Son Y*. Schwann cells differentiated from spheroid-forming cells of rat subcutaneous fat tissue myelinate axons in the spinal cord injury.Exp. Neurol.2010, 222（2）: 304-17. IF: 4.483
  15. Hong HS#, Lee J, Lee E, Kwon YS, Lee E, Ahn W, Jiang MH, Kim JC, Son Y*. A new role of substance P as an injury-inducible messenger for mobilization of CD29(+) stromal-like cells. Nat Med. 2009, 15（4），425-35. IF: 32.621
  16. Yune TY#, Lee JY#, Jiang MH,Kim DW, Choi SY, Oh TH*.Systemic administration of PEP-1-SOD1 fusion protein improves functional recovery by inhibition of neuronal cell death after spinal cord injury. Free Radic. Biol.Med.2008，45（8），1190-1200. IF: 6.020
  17. Yune TY#, Lee JY, Jung GY, Kim SJ, Jiang MH, Kim YC, Oh YJ, Markelonis GJ, Oh TH*. Minocycline alleviates death of oligodendrocytes by inhibiting pro-nerve growth factor production in microglia after spinal cord injury.J Neurosci.2007，18，27（29），7751-61. IF: 5.97

 

教材专著

  1. 医用解剖学 （第二版），人民出版社
  2. 格式解剖学 （第41版），山东科学技术出版社