个人简介
张昭，中山大学“百人计划”青年学术骨干，副教授，硕士生导师。
2018年毕业于香港大学李嘉诚医学院，获哲学博士学位。
2018年至2022年于香港大学从事博士后研究。
2022年获聘中山大学引进人才。
主要研究方向
1. 干细胞疾病模型及临床转化
利用诱导多功能干细胞（induced pluripotent stem cells, iPSCs）及CRISPR/Cas9基因编辑技术，来建立细胞疾病模型，探讨人类遗传疾病的病例机制, 并开发其潜在治疗手段，包括药物治疗，基因治疗及基因修复治疗。
2. 干细胞分化及细胞
利用人类胚胎干细胞（Embryonic stem cell, ESCs）等多功能干细胞，诱导分化为具备组织特异性功能的成体细胞（Somatic stem cells），用于细胞治疗及再生医学研究。
3. 基因治疗研究
临床移植慢病毒（lentivirus）基因修饰的多功能造血干细胞（Hematopoietic stem cells, HSCs）用于治疗遗传病患者，如异染性脑白质退化症（Metachromatic leukodystrophy）；利用转基因动物模型，开发能够用于治疗人类遗传疾病的腺病毒（Adeno-associated viruses）潜在治疗载体。
学术成果
第一作者论文（#共同第一作者,*通讯作者）：
- Q Lian#*, K Zhang#, Z Zhang#, F Duan1, L Guo1, W Luo, W Mok, A Thakur, X Ke, P Motallebnejad, V Nicolaescu, J Chen, C Ma, X Zhou, S Han, T Han, W Zhang, A Tan, T Zhang, X Wang, D Xu, J Xiang, A Xu, C Liao, F Huang, Y Chen, J Na, G Randall, H Tse, Z Chen, H Chen*. Differential effects of macrophage subtypes on SARS-CoV-2 infection in a human pluripotent stem cell-derived model. Nature Communications, 2022. (DOI: doi.org/10.1038/s41467-022-29731-5., 中科院一区，影响因子：14.919)
- Z Zhang#, L Guo#, X Lu#, C Zhang#, X Wang#, L Huang#, F Duan#, H Liang, L Zeng, CY Ma, J Shao, H Li, L Li, L Liu, P Chen, C Li, J Zhang, K Kwan, W Liu, Y Xu, X Gu, H Jiang, H Du, T Zhang, Y Wu, G Yu, J Chen, C Liao, H Tse, R Luo, Z Chen, H Chen*, H Xia*, and Q Lian*. Clinical analysis and pluripotent stem cells-based model reveal possible impacts of ACE2 and lung progenitor cells on infants vulnerable to COVID-19. Theranostics, 2021, 11:2170-2181. (中科院一区，影响因子：11.556，封面文章)
- Z Zhang#, L Guo#, L Huang#, C Zhang#, R Luo, L Zeng, H Liang, X Lu, X Wang, C Ma, J Shao, W Luo, L Li, L Li, Z Li, X Zhou, K Kwan, W Liu, Y Xu, H Jiang, H Liu, H Du, Y Wu, G Yu, J Chen, J Zhang, C Liao, Z Chen, H Tse*, H Xia*, and Q Lian*. Distinct disease severity between children and elderly adults with COVID-19: Roles of ACE2 distribution and lung progenitor cells. Clinical Infectious Diseases, 2021, 73: 4154- 4165. (中科院一区，影响因子：9.079).
- Z Zhang, B Yan, F Gao, X Meng, Q Li, L Zhou, P Chen, W Deng, C Li, W Xu, S Han, H Feng, Y Li, J Chen, Z Yin, HF Tse*, A Xu*, and Q Lian* iPSCs Reveal PUFA Overload-provoked Mitochondrial Stress as a Central Node for RPE Degeneration in Bietti’s Crystalline Dystrophy. Molecular Therapy, 2020, 28: 2642-2661. (中科院一区，影响因子：11.454)
- Y Zhang#, Z Zhang#, P Chen#, C Ma, C Li, T.Y.K. Au, V Tam, Y Peng, R Wu, KC. Cheung, PC Sham, HF Tse, D Chan, VY Leung, KS Cheah*, and Q Lian*. Directed Differentiation of Notochord-like and Nucleus Pulposus-like Cells Using Human Pluripotent Stem Cells. Cell Reports, 2020, 30: 2791-2806.e5. (中科院一区，影响因子：9.423)
- Z Zhang, Y Zhang, F Gao, S Han, KS Cheah, HF Tse, and Q Lian*. CRISPR/Cas9 genome-editing system in human stem cells：current status and prospects. Molecular Therapy-Nucleic Acids. 2017, 9: 230-241. (中科院二区，影响因子：8.886)
近五年参与的其他研究工作
- L Zhou#, K Ho#, T Wong#, Z Zhang, H Loong, N Che, H Yu, K Tan, Man Tong, S Ngan, W Ho, S Ma*. Lineage tracing and single-cell analysis reveal Prom1+ transit-amplifying tumor progenitors and their dynamic cellular transition during liver cancer progression. Gut. (Doi: 10.1136/gutjnl-2021-324321，影响因子：23.059)
- Y Zhang, L Guo, S Han, L Chen, C Li, Z Zhang, D Jiang, X Liang, J Qiu, J Zhang, X Li, C Liao, B Yan, H Tse, and Q Lian*. Adult mesenchymal stem cell ageing interplays with depressed mitochondrial Ndufs6. Cell Death & Disease. 2020, 11:1075. doi: 10.1038/s41419-020-03289-w. (影响因子：8.469)
- C Li, M Cheung, S Han, Z Zhang, L Chen, J Chen*, H Zeng*, and J Qiu*. Mesenchymal stem cells and their mitochondrial transfer: a double-edged sword. Bioscience Reports. 2019 May 31; 39(5): BSR20182417. (影响因子：3.840)
- D Jiang, G Xiong, H Feng, Z Zhang, P Chen, B Yan, L Chen, K Gandhervin, C Ma, C Li, S Han, Y Zhang, C Liao, T Lee, H Tse, Q Fu*, K Chiu*, and Q Lian*. Donation of mitochondria by iPSC-derived mesenchymal stem cells protects retinal ganglion cells against mitochondrial complex I defect-induced degeneration. Theranostics. 2019, 9(8): 2395–2410. (影响因子：11.556)
- X Fan, Z Zhang, C Ma, Q Fu*. Mesenchymal stem cells for inflammatory airway disorders: promises and challenges. Bioscience Reports. 2019, 39(1): BSR20182160. (影响因子：3.840)
- Z Yu, PL Tang, J Wang, S Bao, JT Shieh, AW Leung, Z Zhang, F Gao, SY Wong, AL Hui, Y Gao, N Dung, ZG Zhang, Y Fan, X Zhou, Y Zhang, DS Wong, PC Sham, A Azhar, PY Kwok, PP Tam, Q Lian, KS Cheah, B Wang, and YQ Song*. Mutations in Hnrnpa1 cause congenital heart defects. JCI Insight. 2018, 3: e98555. (影响因子：8.315)
