导师资格：硕士生导师

所在教研室/单位： 博彩公司排名

E-mail：[email protected]

办公电话：020-87334196

研究方向：T淋巴细胞抗病毒、抗肿瘤免疫应答调控

个人简介

张译文，现任博彩公司排名-博彩公司评级 副教授，硕士生导师。2016于中山大学获博士学位。2016年至2021年在中山大学从事博士后及特聘副研究研究。

研究方向为T淋巴细胞抗病毒、抗肿瘤免疫应答调控。主要学术成果为鉴定了新冠病毒逃逸T细胞免疫监察的分子生物学机制；新冠新型纳米颗粒疫苗细胞免疫应答机制；氨基酸信号调控T细胞免疫应答机制。以第一或通讯作者（含共同）在PNAS，Immunity，Cancer Res，J Immunother Cancer，Cell Reports，Signal Transduct Target Ther，J Immunol，J Virology等国际期刊发表十余项高影响力的研究成果。主持国家自然科学基金重大研发计划（培育项目）及青年项目，广东省杰出青年科学基金等科研项目。

学术成果

代表性学术论著

  1. Chen Y#, Yan S#, Pu Z, Feng J, Tan L, Li Y, Hu H, Huang H, Lin Y, Peng Z, He X, Huang F*, Zhang H*, Zhang Y*. Dopamine/DRD5 Signaling Axis Modulates CD8+ T cells into the CD103+ Tissue-resident Memory Fate and Their Antitumor Immunity. Cancer Research.
  2. Zhang Y#, Li R#, Li Y#, Yang H, Zhou L, Yuan J, Pan T, Liu B, Zhang H*, He Y*. Antibody Response and Cross-Neutralization After Omicron BA.2 Infection. Signal Transduction and Targeted Therapy. 
  3. Zhang Y , Chen Y, Li Y, Huang F, Luo B, Yuan Y, Xia B, Ma X, Yang T, Yu F, Liu J, Liu B, Song Z, Chen J, Yan S, Wu L, Pan T, Zhang X, Li R, Huang W, He X, Xiao F, Zhang J*, Zhang H*. The ORF8 Protein of SARS-CoV-2 Mediates Immune Evasion through Downregulating MHC-Ι. Proceedings of the National Academy of Sciences, 2021, 118(23)
  4. Zhang Y , Yan S, Hu H, Li Y, Tan L, Chen Y, Peng Z, Yuan Y, Liu W, Huang W, Yu F, He X, Li B*, Zhang H*. Amino Acids and RagD Potentiate mTORC1 Activation in CD8+ T Cells to Confer Antitumor Immunity. Journal for ImmunoTherapy of Cancer, 2021, 9(4).
  5. Yuan Y#, Zhang X#, Chen R#, Li Y, Wu B, Li R, Zou F, Ma X, Wang X, Chen Q, Deng J, Zhang Y, Chen T, Lin Y, Yan S, Zhang X, Li C, Bu X, Peng Y, Ke C, Deng K, Pan T, He X, Zhang Y*, and Zhang H*. A bivalent nanoparticle vaccine exhibits potent cross-protection against the variants of SARS-CoV-2. Cell Reports. 2021: 110256
  6. Ma X#, Zou F#, Yu F#, Li R#, Yuan Y#, Zhang Y#, Zhang X, Deng J, Chen T, Song Z, Qiao D, Zhan Y, Liu J, Zhang J, Zhang X, Peng Z, Li Y, Lin Y, Liang L, Wang G, Chen Y, Chen Q, Pan T, He X, Zhang H. Nanoparticle Vaccines Based on the Receptor Binding Domain (RBD) and Heptad Repeat (HR) of SARS-CoV-2 Elicit Robust Protective Immune Responses. Immunity. 2020, 53(6): 1315-1330. e9
  7. Pan T#, Hu Z#, Hu F#, Zhang Y#, Liu B, Ke C, She Q, He X, Tang X*, Zhang H*. Significantly reduced abilities to cross-neutralize SARS-CoV-2 variants by sera from convalescent COVID-19 patients infected by Delta or early strains. Cellular & Molecular Immunology. 2021: 1-3.
  8. Zhang Y #, Chen Y#, Ma R, Jiang Y, Liu J, Lin Y, Chen S, Xia M, Zou F, Zhang J, Pan T, Wang L, Wei L*, Zhang H*. UHRF1 Controls Thymocyte Fate Decisions Through the Epigenetic Regulation of EGR1 Expression. The Journal of Immunology. 2020, 204(12): 3248-3261.
  9. Luo B#, Zhan Y#, Liu J, Luo M, Dong H, Liu J, Lin Y, Zhang J, Wang G, Verhoeyen E, Zhang Y*, Zhang H*. Engineered Production of Anti-PD1 Antibody-Expressing Long-lived Plasma Cells by CRISPR/CAS9-Mediated Targeted Gene Integration. Cell Death and Diseases. 2020 Nov 12;11(11):973.
  10. Zhang Y， Liu W, Chen Y, Liu J, Wu K, Su L, Zhang W, Jiang Y, Zhang X, Zhang Y, Liu C, Tao L, Liu B*, and Zhang H*. A cellular microRNA facilitates regulatory T lymphocyte development by targeting the FOXP3 promoter TATA-box motif. The Journal of Immunology. 2018. 200(3):1053-1063.
  11. Pan T, Peng Z, Tan L, Zou F, Zhou N, Liu B, Liang L, Chen C, Liu J, Wu L, Liu G, Peng Z, Liu W, Ma X, Zhang J, Zhu X, Liu T, Li M, Huang X, Tao L, Zhang Y*, and Zhang H*. Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) Potently Inhibit the Replication of Zika Viruses by Inducing the Degradation of Axl. Journal of Virology. 2018, 92(20): e01018-18.
  12. Chen Y#, Yu F #, Jiang Y, Chen J, Wu K, Chen X, Lin Y, Zhang H, Li L*, and Zhang Y*. Adoptive Transfer of Interleukin-21-stimulated Human CD8+ T Memory Stem Cells Efficiently Inhibits Tumor Growth. Journal of Immunotherapy. 2018, 41(6): 274. (IF:4.5).