个人简介
教育背景
2009-2014 中山大学 博士 微生物学
2005-2009 中国药科大学 学士 制药工程
工作经历
2020-至今 副教授 中山大学人类病毒学研究所
2014-2020 博士后 宾夕法尼亚大学Perelman医学院
学术成果
发表论文
1.Zhang X, Zhang H, He X#. SARS-CoV-2 Omicron: a new challenge for pandemic and vaccine. Signal Transduct Target Ther 2022, 7(1): 211.
2.Zhang X, Wu S, Wu B, Yang Q, Chen A, Li Y, Zhang Y, Pan T, Zhang H#, He X#. SARS-CoV-2 Omicron strain exhibits potent capabilities for immune evasion and viral entrance. Signal Transduct Target Ther 2021, 6(1): 430.
3.Zhang X, Yuan Y, Wu B, Wang X, Lin Y, Luo Y, Li R, Chen T, Deng J, Zhang X, Zou F, He X#, Zhang H#. Improvement of a SARS-CoV-2 vaccine by enhancing the conjugation efficiency of the immunogen to self-assembled nanoparticles.Cell Mol Immunol. 2021 Aug;18(8):2042-2044.
4.Li R*, Ma X*, Deng J, Chen Q, Liu W, Peng Z, Qiao Y, Lin Y, He X#, Zhang H#.Differential efficiencies to neutralize the novel mutants B.1.1.7 and 501Y.V2 by collected sera from convalescent COVID-19 patients and RBD nanoparticle-vaccinated rhesus macaques. Cell Mol Immunol. 2021 Apr;18(4):1058-1060.
5.He X#, Feng Z#, Ma J, Ling S, Cao Y, Gurung B, Wu Y, Katona BW, O'Dwyer KP, Siegel DL, June CH, Hua X. Bispecific and split CAR T cells targeting CD13 and TIM3 eradicate acute myeloid leukemia. Blood. 2020 Mar 5;135(10):713-723.
6.He X#, Feng Z, Ma J, Zhang X, Ling S, Cao Y, Xing B, Wu Y, Wang L, Katona BW, June CH, Hua X. CAR T cells targeting CD13 controllably induce eradication of acute myeloid leukemia with a single domain antibody switch. Leukemia. 2021;35(11):3309-13.
7.Feng Z*, He X*, Zhang X, Wu Y, Xing B, Knowles A, Shan Q, Miller S, Hojnacki T, Ma J, Katona BW, Gade TPF, Schrader J, Metz DC, June CH, Hua X#. Potent suppression of neuroendocrine tumors and gastrointestinal cancers by CDH17CAR T cells without toxicity to normal tissues. Nature Cancer 2022, 3(5): 581-594.
8.Li L, Zhu X, Qian Y, Yuan X, Ding Y, Hu D, He X#, Wu Y#. Chimeric Antigen Receptor T-Cell Therapy in Glioblastoma: Current and Future. Front Immunol 2020, 11: 594271.
9.He X*, Chen X*, Zhang X*, Duan X, Pan T, Hu Q, Zhang Y, Zhong F, Liu J, Zhang H, Luo J, Wu K, Peng G, Luo H, Zhang L, Li X#, Zhang H#. An Lnc RNA (GAS5)/SnoRNA-derived piRNA induces activation of TRAIL gene by site-specifically recruiting MLL/COMPASS-like complexes. Nucleic Acids Res. 2015 Apr 20;43(7):3712-25.
科研项目
国家自然科学基金面上项目（82171825）主持，2022-2025
国家自然科学基金青年基金（32100743）主持，2022-2024
广东省自然科学基金-面上项目（2022A1515010132）主持，2022-2024
广东省重点领域研发计划项目（2022B1111020004）核心成员，2022-20226
中山大学“百人计划”，2020-2022
