个人简介

徐涛，中山大学引进中青年杰出人才，教授，博士生导师。在中科院上海生物化学与细胞生物学研究所（现中国科学院分子细胞科学卓越创新中心）获得细胞生物学博士学位。在斯柯里普斯研究所（The Scripps Research Institute）以及美国加州大学旧金山分校戴维•格拉斯通研究所（J. David Gladstone Institutes，University of California, San Francisco）从事博士后研究工作。2018年由中山大学引进全职回国至今。2017年至今已经以独立通讯或第一作者身份在Nature, Journal of Experimental Medicine等杂志发表文章多篇，总引用2000多次。

主要科学贡献

TH17细胞在清除细菌和真菌感染中发挥至关重要的保护性作用，但在一系列的自身免疫性疾病，如多发性硬化病，银屑病，炎症性肠道疾病，风湿性关节炎等都发挥着非常重要的致病性作用，因此研究TH17细胞发育分化具有重要意义。徐涛博士在TH17细胞的发育分化中取得了重要进展，系列工作包括：

  1. 国际上首次揭示谷氨酰胺代谢能够通过影响表观遗传及转录来调控TH17细胞的命运决定（Nature, 2017, 2023）;
  2. 证明TCR-Lck/Fyn-STAT3轴在调控TH17细胞分化中的重要作用,提出了TCR信号和细胞因子信号协同作用诱导STAT3的磷酸化，进而促进TH17细胞命运决定这一全新的理论模型(Journal of Experimental Medicine，2024)。

Cell Metabolism, Nature Review Immunology, Cell Research等国内外顶刊为这些工作发表了专评。相关工作已被Nature, Cell, Science, Immunity, Nature Immunology, Nature Biotechnology, Nature Review Immunology, Annual Review Immunology，Nature Review Drug discovery等顶级刊物多次正面引用。这些工作对于推动TH17细胞的发育分化以及TCR信号和细胞内代谢在T细胞命运决定中的作用提供了全新的认识，并为靶向TH17细胞的药物研发提供了全新的靶点。

目前研究方向

肿瘤免疫疗法是近年来生物医学领域内最重大的突破。Science杂志将其列为2013年度最重要的科学突破。2018年诺贝尔生理医学奖授予了在肿瘤免疫疗法，特别是免疫检查点疗法中做出巨大贡献的两位科学家James Allison 和Tasuku Honjo。与传统的化疗药相比，肿瘤免疫疗法具有治愈后维持时间长（可以长达10年以上）和疾病不再复发（disease free survival）的优势。目前临床上使用的免疫检查点阻断疗法主要是通过恢复抗原特异性T细胞的功能，从而使其更好的发挥肿瘤杀伤能力。

实验室目前致力于：

1）抗原特异性T细胞和其识别的多肽抗原的快速识别和鉴定；

2）研究抗原特异性T细胞在肿瘤内部如何发育分化，从而为如何提高此类T细胞的肿瘤杀伤功能提供新的靶标；同时也关注在其它疾病（如自身免疫性疾病）中，抗原特异性T细胞在体内如何发育分化，从而为更精准靶向致病性T细胞提供新靶点；

3）肿瘤细胞是如何逃脱免疫监视。

同时我们也将着力于将这些基础研究的成果转化为临床应用。

发表文章

(# Co-first author, *corresponding author)

  1. Zhen Qin#, Ruining Wang#, Ping Hou, Yuanyuan Zhang, Qianmu Yuan, Ying Wang, Yuedong Yang, Tao Xu*. TCR signaling induces STAT3 phosphorylation to promote TH17 cell differentiation. Journal of Experimental Medicine 221(03), (2024)
  2. Zhen Qin#, Ping Hou#, Huizhen Lin, Minghui Chen, Ruining Wang, Tao Xu*. Inhibition of Lck/Fyn kinase activity promotes the differentiation of induced Treg cells through AKT/mTOR pathway. International Immunopharmacology 134, (2024)
  3. Wanning Chen#, Yichen Li#, Wenxia Wang#, Sheng Gao, Jun Hu, Bingjie Xiang, Dingfeng Wu, Na Jiao, Tao Xu, Min Zhi*, Lixin Zhu*, Ruixin Zhu*. Enhanced microbiota profiling in patients with quiescent Crohn’s disease through comparison with paired healthy first-degree relatives. Cell Reports Medicine 5(7), 2024.
  4. Tao Xu*, Zhen Qin, Xiaohu Wang, Chen Dong*, Edward M. Driggers*, Sheng Ding*. Reply to: GOT1 constrains TH17 cell differentiation, while promoting iTreg cell differentiation. Nature 614, E12-E14 (2023)
  5. Di Che#, Mingshuo Wang#, Juan Sun, Bo Li, Tao Xu, Yuxiong Lu, Haiyan Pan, Zhaoliang Lu* and Xiaoqiong Gu*. KRT6A Promotes Lung Cancer Cell Growth and Invasion Through MYC-Regulated Pentose Phosphate Pathway. Front Cell Dev Biol. 9: 694071 (2021);
  6. Sijing Cheng, Dingfeng Wu, Jie Li, Yifeng Zou, Yunle Wan, Lihan Shen, Lixin Zhu, Mang Shi, Linlin Hou, Tao Xu, Na Jiao, Yichen Li, Yibo Huang, Zhipeng Tang, Mingwei Xu, Shusong Jiang, Maokun Li, Guangjun Yan, Ping Lan, Ruixin Zhu*. Risk factors for the critical illness in SARS-CoV-2 infection: a multicenter retrospective cohort study. Respiratory research 20, 1-12 (2020).
  7. Tao Xu#, Kelly M. Stewart#, Xiaohu Wang#, Kai Liu, Min Xie, Jae Kyu Ryu, Ke Li, Tianhua Ma, Haixia Wang, Lu Ni, Saiyong Zhu, Nan Cao, Dongwei Zhu, Yu Zhang, Katerina Akassoglou, Chen Dong*, Edward M. Driggers* and Sheng Ding*. Metabolic control of TH17/iTreg balance through an epigenetic mechanism. Nature 548, 228-233 (2017). Preview at Cell Metabolism 26, 588-590. 
  8. Baoming Nie, Tao Nie, Xiaoyan Hui, Ping Gu, Liufeng Mao, Kuai Li, Ran Yuan, Jiashun Zheng, Haixia Wang, Ke Li, Shibing Tang, Yu Zhang, Tao Xu, Aimin Xu, Donghai Wu, Sheng Ding*. Brown adipogenic reprogramming induced by a small molecule. Cell reports 18(3), 624-635 (2017)
  9. Nan Cao, Yu Huang, Jiashun Zheng, C Ian Spencer, Yu Zhang, Ji-Dong Fu, Baoming Nie, Min Xie, Mingliang Zhang, Haixia Wang, Tianhua Ma, Tao Xu, Guilai Shi, Deepak Srivastava, Sheng Ding*. Conversion of human fibroblasts into functional cardiomyocytes by small molecules. Science 352 (6290), 1216-1220 (2016)
  10. Yu Zhang#, Nan Cao#, Yu Huang, C Ian Spencer, Ji-dong Fu, Chen Yu, Kai Liu, Baoming Nie, Tao Xu, Ke Li, Shaohua Xu, Benoit G Bruneau, Deepak Srivastava, Sheng Ding*. Expandable cardiovascular progenitor cells reprogrammed from fibroblasts. Cell Stem Cell 18 (3), 368-381 (2016). 
  11. Saiyong Zhu, Holger A. Russ, Xiaojing Wang, Mingliang Zhang, Tianhua Ma, Tao Xu, Shibing Tang, Matthias Hebrok & Sheng Ding*. Human pancreatic beta-like cells converted from fibroblasts. Nature Communication 7 (2016).
  12. Tianhua Ma#, Jun Li#, Yue Xu#, Chen Yu, Tao Xu, Haixia Wang, Kai Liu, Nan Cao, Bao-ming Nie, Saiyong Zhu, Shaohua Xu, Ke Li, Wan-Guo Wei, Kun-Liang Guan and Sheng Ding*. Atg5-independent autophagy regulates mitochondrial clearance and is essential for iPSC reprogramming. Nature Cell Biology 17, 1379-1387 (2015)
  13. Ke Li, Saiyong Zhu, Holger A. Russ, Shaohua Xu, Tao Xu, Yu Zhang, Matthias Hebrok, and Sheng Ding*. Small molecules facilitate the reprogramming of mouse fibroblasts into pancreatic lineages. Cell Stem Cell 14 (2), 228-236 (2014). 
  14. Haixia Wang, Nan Cao, C. Ian Spencer, Baoming Nie, Tao Xu, Yu Zhang, Xiaojing Wang, Deepak Srivastava, and Sheng Ding*. Small Molecules Enable Cardiac Reprogramming of Mouse Fibroblasts with a Single Factor, Oct4. Cell Reports 2, 951-960 (2014). 
  15. Na Wei, Yi Shi, Lan N Truong, Kathleen M Fisch, Tao Xu, Elisabeth Gardiner, Guangsen Fu, Yun-Shiuan Olivia Hsu, Shuji Kishi, Andrew I Su, Xiaohua Wu, Xiang-Lei Yang*. Oxidative Stress Diverts tRNA Synthetase to Nucleus for Protection against DNA Damage. Molecular cell, 56 (2), 323-32 (2014).
  16. Tao Xu#, Mingliang Zhang#, Timothy Laurent, Min Xie, and Sheng Ding. Chemical approaches for modulating lineages-restricted stem cells and progenitors. Stem Cells Transl Med. 2(5):355-61 (2013).(Invited Review) 
  17. Guangsen Fu, Tao Xu, Yi Shi, Na Wei, Xiang-Lei Yang*. tRNA-controlled Nuclear Import of a Human tRNA Synthetase. J Biol Chem 287(12), 9330-9334 (2012)
  18. Tao Xu#, Xiaohu Wang#, Bo Zhong, Roza I. Nurieva, Sheng Ding*, and Chen Dong*. Ursolic acid suppresses interleukin-17 (IL-17) production by selectively antagonizing the function of RORүt protein. J Biol Chem. 286(26):22707-10 (2011). (Highlighted in SciBX, a Nature sister journal; and in Nature Review Immunology). 
  19. Tao Xu#, Lei Zhang#, Zhen H. Geng, Hai-Bo Wang, Jin-Tao Wang, Ming Chen, Jian-Guo Geng*. P-selectin Cross-links PSGL-1 and enhances Neutrophil Adhesion to Fibrinogen and ICAM-1 in a Src Kinase-dependent, but GPCR-independent Mechanism. Cell Adhesion & Migration, 1(3). 1-9 (2007),
  20. Hai-Bo Wang#, Jin-Tao Wang#, Lei Zhang#, Zhen H Geng#, Wei-Li Xu#, Tao Xu#, Yuqing Huo, Xueliang Zhu, Edward F Plow, Ming Chen* & Jian-Guo Geng*. P-selectin primes leukocyte integrin activation during inflammation. Nature Immunology 2007, 8(8):882-92. 

专利

  1. Tao Xu and Sheng Ding. Methods of Treating Diseases by Metabolic control of T-Cell differentiation, PCT/US2017/013252

科研项目

  1. 国家重点研发计划课题，2019-2024
  2. 国家自然科学基金面上项目，2024-2027
  3. 国家自然科学基金面上项目，2022-2025
  4. 国家自然科学基金面上项目，2020-2023
  5. 广东省自然科学基金面上项目，2021-2023
  6. 广东省创新创业团队项目， 2020-2025
  7. 中山大学青年教师重点培育项目，2019-2021
  8. 校企合作项目，2023-2026