个人简介

 2002年获微生物学博士学位;2002-2004年,于美国弗吉尼亚州立大学(VCU)接受博士后培训;2005-2008年,在美国加利福尼亚大学(UCSB)任研究助理。2009年作为百人计划引进人才,受聘于博彩公司排名-博彩公司评级 。研究方向是宿主细胞与虫媒病毒的相互作用,抗病毒感染的细胞应答,抗病毒药物的筛选等。

学术成果

  1. Changbai Huang, Fei Feng, Yongxia Shi, Wenhui Li, Ziqiao Wang, Yunkai Zhu, Shuai Yuan, Dandan Hu, Jun Dai, Qiqi Jiang, Rong Zhang, Chao Liu*, Ping Zhang*. Protein Kinase C inhibitors reduce SARS-CoV-2 replication in cultured cells. Microbiology Spectrum, 2022, e0105622
  2. Shili Zhou, Quanshi Lin, Changbai Huang, Xiaocao Ma, Xiaotong Luo, Xu Tian, Chao Liu*, Ping Zhang* Rottlerin plays an antiviral role at early and late steps of Zika virus infection. Virologica Sinica. 2022, 37 (5) 685–694
  3. Huixin Gao#, Yuxia Lin #, Changbai Huang#, Xiaobo Li, Michael S. Diamond, Chao Liu, Rong Zhang*, and Ping Zhang* A genome-wide CRISPR screen identifies HuR as a regulator of apoptosis induced by dsRNA and virus. Journal of Cell Science, 2022, 135(6): jcs.258855
  4. Yuxia Lin#, Changbai Huang #, Huixin Gao, Xiaobo Li, Quanshi Lin, Shili Zhou, Zhiting Huo, Yanxia Huang, Chao Liu*, Ping Zhang*. AMBRA1 promotes dsRNA- and virus-induced apoptosis through interacting with and stabilizing MAVS. Journal of Cell Science, 2021, 135(1):jcs258910
  5. Yi Wang, Zhiting Huo, Quanshi Lin, Yuxia Lin, Cancan Chen, Yanxia Huang, Changbai Huang, Junfang He, Chao Liu*, Ping Zhang*. Positive feedback loop of lncRNA OASL-IT1 and innate immune response restricts the replication of Zika virus in epithelial A549 cells. Journal of Innate Immunity, 2021,13(2):1-15
  6. Yanxia Huang#, Quanshi Lin#, Zhiting Huo, Cancan Chen, Shili Zhou, Xiaocao Ma, Huixin Gao, Yuxia Lin, Xiaobo Li, Junfang He, Ping Zhang*, and Chao Liu*. Inositol requiring enzyme 1α promotes Zika virus infection through regulating stearoyl-CoA desaturase 1 mediated lipid metabolism.  Journal of Virology, 2020, 94(23):e01229-20
  7. Quanshi Lin#, Shili Zhou#, Yanxia Huang, Zhiting Huo, Cancan Chen, Xin Luo, Junfang He, Chao Liu*, and Ping Zhang*. ANKS4B restricts replication of Zika virus by downregulating the autophagy. Frontiers in Microbiology, 2020, 11:1745.
  8. Shili Zhou, Chao Yang, Fanfan Zhao, Yanxia Huang, Yuxia Lin, Changbai Huang, Xiaocao Ma, Jingjie Du, Yi Wang, Gang Long, Junfang He, Chao Liu*, and Ping Zhang*. Double-stranded RNA deaminase ADAR1 promotes the Zika virus replication by inhibiting the activation of protein kinase PKR. Journal of Biological Chemistry, 2019, 294(48):18168-18180.
  9. Yi Wang#, Xiaoyan Chen#, Jiong Xie, Shili Zhou, Yanxia Huang, Yiping Li, Xiaobo Li, Chao Liu, Junfang He*, Ping Zhang* . RNA helicase A is an important host factor involved in dengue virus replication. Journal of Virology, 2019, 93(4): e01306-18
  10. Huixin Gao#, Yuxia Lin#, Junfang He, Shili Zhou, Mujiao Liang, Changbai Huang, Xiaobo Li, Chao Liu*, Ping Zhang*. Role of heparan sulfate in the Zika virus entry, replication, and cell death. Virology, 2019, 529: 91-100
  11. Yi Wang, Ping Zhang*. Recent advances in the identification of the host factors involved in dengue virus replication. Virology Sinica, 2017, 32(1)23–31
  12. Feng Xu, Xiaobo Li, Peifen Zhang, Jun Xia, Yi Wang, Chao Yang, Huixin Gao, Shili Zhou, Ping Zhang*. Melanoma differentiation-associated gene 5 is involved in the induction of stress granules and autophagy by protonophore CCCP. Biological Chemistry, 2016, 397 (1):67-74
  13. Yuye Li#, Siyu Wu#, Jieying Pu, Xi Huang, Ping Zhang*. Dengue Virus Upregulates Expression of Notch Ligands Dll1 and Dll4 Through IFN-β Signaling Pathway. Immunology, 2015, 144(1):127-38
  14. Xiaoyan Chen, Jun Xia, Qirui Zhao, Yi Wang, Jingyu Liu, Lianqiang Feng, Junfang He*, Ping Zhang*. Eukaryotic initiation factor 4AI interacts with NS4A of Dengue virus and plays an antiviral role. Biochemical and Biophysical Research Communications, 2015, 461 (1): 148-153
  15. Jun Xia#, Xiaoyan Chen#, Feng Xu, Yi Wang, Yongxia Shi, Yuye Li, Junfang He*, Ping Zhang*. Infection of Dengue virus induces formation of G3BP1 granules in human lung epithelial cells. Archives of Virology, 2015, 160(12):2991-2999
  16. Peifen Zhang#, Yuye Li#, Jun Xia, Junfang He, Jieying Pu, Jiong Xie, Siyu Wu, Lianqiang Feng, Xi Huang, Ping Zhang*. IPS-1 plays an essential role in dsRNA-induced stress granule formation by interacting with PKR and promoting its activation. Journal of Cell Science, 2014, 127: 2471-2482

科研项目

  1. 国家自然科学基金面上项目,82271385, 核膜蛋白SUN2在寨卡病毒致神经系统疾病中的作用机制研究
  2. 广州市科技局重点研发计划,202206010114, 抗RNA病毒药物的机理与应用研究
  3. 国家自然科学基金面上项目,31970887,一个新的长链非编码RNA通过正反馈调控干扰素的产生抑制寨卡病毒的复制
  4. 广东省自然科学基金面上项目,2021A1515011491,基于CRISPR/Cas9技术筛选寨卡病毒的宿主因子与功能研究
  5. 国家自然科学基金面上项目,81371794,Notch 受登革病毒调控的分子机制及其对固有免疫和病毒复制的影响
  6. 国家自然科学基金面上项目,81171576,PKR在登革病毒诱导干扰素合成过程中的调控作用与分子机制
  7. 国家自然科学基金青年项目,30901345,与 PKR 蛋白激酶相互作用的先天免疫相关蛋白的鉴定和功能分析
  8. 广东省科技计划项目, 2017A050501012, RNA编辑酶ADAR1促寨卡病毒复制的分子机制研究
  9. 中央高校基本科研业务费资助项目, 17ykjc01, 非凋亡性细胞死亡的关键调控分子的鉴定及其在登革病毒免疫病理中的作用
  10. 广东省自然科学基金重点项目,2014A030311007,PKR相互作用蛋白RHA促登革病毒复制的分子机理
  11. 广东省自然科学基金面上项目,S2013010016454,巨噬细胞通过激活Notch信号抑制登革病毒的复制
  12. 广东省自然科学基金面上项目,9151008901000083,与PKR相互作用的先天免疫调控蛋白的鉴定和功能分析

学术兼职

American Society for Virology 会员