导师资格：硕士生导师

所在教研室/单位： 人体解剖学教研室

行政职务： 人体解剖与生理系副书记

E-mail：[email protected]

通信地址： 医学科技楼北607

办公电话：87330218-838

研究方向：1.老年性痴呆免疫治疗 ; 2.获得性免疫对中枢神经发育及神经再生影响机制

个人简介

邹俊涛，博士，博彩公司排名-博彩公司评级 人体解剖学副教授, 硕士生导师，人体解剖与生理学系副书记。本科毕业于湖北医药学院临床医学专业，硕士及博士毕业于博彩公司排名-博彩公司评级 人体解剖与组织胚胎学专业。2010年中山大学博士后出站。2010.9-2011.9及2018.4-2019.4于香港中文大学脑研究中心访问学习。主要研究方向为老年性痴呆免疫治疗，获得性免疫对中枢神经发育及神经再生影响机制的研究。主要研究成果在Neuroscience, Int Immunopharmacol, Neurosci Bull, Brain Behav Immun, Neurobiol Learn Mem, J Neurol Sci，Neurochem Int，Brain Behav Immun，J Neuroimmunol，Neuroreport，Hum Vaccin Immunother，Brain Research等杂志上发表。主持国家自然科学基金及省、市级等项目10多项。研究成果获得广东医学科技奖二等奖（GMDA202002202，接种卡介苗和流感疫苗促进神经和认知发育及预防自闭症的作用和机制）。

学术成果

  1. Wang G, Zhang H, Sun J, Zhang Y, He F, Zou J*. Cyclosporin A impairs neurogenesis and cognitive abilities in brain development via the IFN-γ-Shh-BDNF pathway. International immunopharmacology. 2021;96:107744. IF5.714
  2. Yuan Q, Liu X, Zhang Y, Xian YF, Zou J, Zhang X, et al. Established Beta Amyloid Pathology Is Unaffected by TREM2 Elevation in Reactive Microglia in an Alzheimer's Disease Mouse Model. Molecules (Basel, Switzerland). 2021;26(9).
  3. Yuan X, He F, Zheng F, Xu Y, Zou J*. Corrigendum to Interferon-gamma Facilitates Neurogenesis by Activating Wntβ-Catenin Cell Signaling Pathway via Promotion of STAT1 Regulation of the β-Catenin Promoter [Neuroscience 448 (2020) 219-233]. Neuroscience. 2021;459:198.
  4. Yuan X, He F, Zheng F, Xu Y, Zou J*. Interferon-gamma Facilitates Neurogenesis by Activating Wnt/β-catenin Cell Signaling Pathway via Promotion of STAT1 Regulation of the β-Catenin Promoter. Neuroscience. 2020;448:219-33.
  5. Xu Y, He F, Qi F, Yang G, Zheng F, Yang J, Zou J*. Remodeling the Th1 polarized systemic environment contributes to neurogenesis and cognitive function via the Wnt7a pathway in neonatal mice. Neurobiol Learn Mem. 2017;141:60-71.
  6. Wang G, He F, Xu Y, Zhang Y, Wang X, Zhou C, Zou J*. Immunopotentiator Thymosin Alpha-1 Promotes Neurogenesis and Cognition in the Developing Mouse via a Systemic Th1 Bias. Neurosci Bull. 2017;33(6):675-84. IF5.271
  7. 许云龙, 何芬, 郑福祥, 邹俊涛*. 卵白蛋白致敏降低新生期小鼠神经发生和学习记忆功能. 解剖学研究. 2016;38（2）:123-8.
  8. 王阁, 余文富, 王潇, 何芬, 邹俊涛*. 胸腺肽a1对小鼠新生期感染所致学习记忆障碍的影响. 中华神经医学杂志. 2017;16(2):121-6.
  9. 郑福祥, 许云龙, 何芬, 邹俊涛*. Wnt7a蛋白在IFN-γ促神经干细胞增殖中的影响. 解剖学研究. 2017;39(2):145-9.
  10. 何芬, 魏旋, 孙建聪, 莫威, 袁婷, 宫庆娟, 邹俊涛*. 醋酸格拉默免疫介导影响神经干细胞的增殖及分化. 解剖学研究.40(6):470-3.
  11. 周春华, 何芬, 邹俊涛*. Hippo-YAP信号通路在IFN-γ促神经干细胞增殖中的作用及其机制. 解剖学研究. 2019;41(2):88-92.
  12. 何芬, 袁婷, 魏旋, 莫威, 邹俊涛*, 孙建聪. 高尔基体磷酸化蛋白2对人结直肠癌细胞放射敏感性的影响. 解剖学研究. 2019;41(5):442-8.
  13. 王阁, 张雨微, 祁方窻, 许云龙, 姚志彬, 胡丹丹, 邹俊涛*. 环孢素A对新生小鼠的海马神经发生和认知能力的影响. 解剖学研究. 2015;37(2):100-3.
  14. Shi C, Wu F, Xu J, Zou J*. Bilobalide regulates soluble amyloid precursor protein release via phosphatidyl inositol 3 kinase-dependent pathway. Neurochem Int. 2011;59(1):59-64.
  15. Shi C, Zou J#, Li G, Ge Z, Yao Z, Xu J. Bilobalide protects mitochondrial function in ovariectomized rats by up-regulation of mRNA and protein expression of cytochrome c oxidase subunit I. J Mol Neurosci. 2011;45(2):69-75.
  16. Zou J, Yao Z, Zhang G, Wang H, Xu J, Yew DT, et al. Vaccination of Alzheimer's model mice with adenovirus vector containing quadrivalent foldable Abeta(1-15) reduces Abeta burden and behavioral impairment without Abeta-specific T cell response. J Neurol Sci. 2008;272(1-2):87-98.
  17. Yuan Q, Liu X, Xian YF, Tang Y, Zou J, Zhang X, et al. Origins of Beta Amyloid Differ Between Vascular Amyloid Deposition and Parenchymal Amyloid Plaques in the Spinal Cord of a Mouse Model of Alzheimer's Disease. Mol Neurobiol. 2019.
  18. Li Q, Xuan A, Qi F, Yang J, Zou J, Yao Z. Synergistic effects of combined vaccination with BCG and influenza vaccines on spatial cognition and hippocampal plasticity in rats. Brain Res Bull. 2019;149:268-78.
  19. Wu Y, Qi F, Song D, He Z, Zuo Z, Yang Y, et al. Prenatal influenza vaccination rescues impairments of social behavior and lamination in a mouse model of autism. Journal of neuroinflammation. 2018;15(1):228.
  20. Qi F, Zuo Z, Hu S, Xia Y, Song D, Kong J, et al. An enriched environment restores hepatitis B vaccination-mediated impairments in synaptic function through IFN-gamma/Arginase1 signaling. Brain Behav Immun. 2018;71:116-32.
  21. Zuo Z, Qi F, Yang J, Wang X, Wu Y, Wen Y, et al. Immunization with Bacillus Calmette-Guerin (BCG) alleviates neuroinflammation and cognitive deficits in APP/PS1 mice via the recruitment of inflammation-resolving monocytes to the brain. Neurobiol Dis. 2017;101:27-39.
  22. Qi F, Zuo Z, Yang J, Hu S, Yang Y, Yuan Q, et al. Combined effect of BCG vaccination and enriched environment promote neurogenesis and spatial cognition via a shift in meningeal macrophage M2 polarization. Journal of neuroinflammation. 2017;14(1):32.
  23. Yang J, Qi F, Yang Y, Yuan Q, Zou J, Guo K, et al. Neonatal hepatitis B vaccination impaired the behavior and neurogenesis of mice transiently in early adulthood. Psychoneuroendocrinology. 2016;73:166-76.
  24. Yang J, Qi F, Gu H, Zou J, Yang Y, Yuan Q, et al. Neonatal BCG vaccination of mice improves neurogenesis and behavior in early life. Brain Res Bull. 2016;120:25-33.
  25. Qi F, Yang J, Xia Y, Yuan Q, Guo K, Zou J, et al. A(H1N1) vaccination recruits T lymphocytes to the choroid plexus for the promotion of hippocampal neurogenesis and working memory in pregnant mice. Brain Behav Immun. 2016;53:72-83.
  26. Li Q, Zhang Y, Zou J, Qi F, Yang J, Yuan Q, et al. Neonatal vaccination with bacille Calmette-Guerin promotes the dendritic development of hippocampal neurons. Hum Vaccin Immunother. 2016;12(1):140-9.
  27. Zhang Y, Zou J, Yang J, Yao Z. 4Abeta1-15-Derived Monoclonal Antibody Reduces More Abeta Burdens and Neuroinflammation than Homologous Vaccine in APP/PS1 Mice. Curr Alzheimer Res. 2015;12(4):384-97.
  28. Zhang Y, Li Q, Zou J, Zuo Z, Yao Z. Continuous vaccinations of 4Abeta1-15 induces specific fluctuation of inflammatory factors accompany with pathologic alterations alleviation in APP/PS1 mice. Hum Vaccin Immunother. 2015;11(11):2674-81.
  29. Li Q, Qi F, Yang J, Zhang L, Gu H, Zou J, et al. Neonatal vaccination with bacillus Calmette-Guerin and hepatitis B vaccines modulates hippocampal synaptic plasticity in rats. J Neuroimmunol. 2015;288:1-12.
  30. Xia Y, Qi F, Zou J, Yao Z. Influenza A(H1N1) vaccination during early pregnancy transiently promotes hippocampal neurogenesis and working memory. Involvement of Th1/Th2 balance. Brain Res. 2014;PMID: 25307140.
  31. Xia Y, Qi F, Zou J, Yang J, Yao Z. Influenza vaccination during early pregnancy contributes to neurogenesis and behavioral function in offspring. Brain Behav Immun. 2014;42:212-21.
  32. He F, Zou JT, Zhou QF, Niu DL, Jia WH. Glatiramer acetate reverses cognitive deficits from cranial-irradiated rat by inducing hippocampal neurogenesis. J Neuroimmunol. 2014;271(1-2):1-7.
  33. Guan X, Yang J, Gu H, Zou J, Yao Z. Immunotherapeutic efficiency of a tetravalent Abeta1-15 vaccine in APP/PS1 transgenic mice as mouse model for Alzheimer's disease. Hum Vaccin Immunother. 2013;9(8):1643-53.
  34. Tan L, Wang H, Tan X, Zou J, Yao Z. Yeast expressed foldable quadrivalent Abeta15 elicited strong immune response against Abeta without Abeta-specific T cell response in wild C57BL/6 mice. Hum Vaccin Immunother. 2012;8(8):1090-8.
  35. Guan X, Zou J, Gu H, Yao Z. Short amyloid-beta immunogens with spacer-enhanced immunogenicity without junctional epitopes for Alzheimer's disease immunotherapy. Neuroreport. 2012;23(15):879-84.
  36. Zhu J, Gu H, Yao Z, Zou J, Guo K, Li D, et al. The nestin-expressing and non-expressing neurons in rat basal forebrain display different electrophysiological properties and project to hippocampus. BMC Neurosci. 2011;12:129.
  37. Li H, Zou J, Yao Z, Yu J, Wang H, Xu J. Tetravalent Abeta1-15 vaccine reduces TCR-positive cell infiltration and up-regulates p75 in Tg2576 brains compared to Abeta42 vaccine. J Neuroimmunol. 2010;219(1-2):8-16.
  38. Guo KH, Zhu JH, Yao ZB, Gu HY, Zou JT, Li DP. Chemical identification of nestin-immunoreactive neurons in the rat basal forebrain: a re-examination. Neurochem Int. 2010;56(5):694-702.
  39. Zhang Y, Ma Y, Lu HP, Gao JH, Liang CS, Liu CZ, et al. Inhibition of human prostate cancer xenograft growth by 125I labeled triple-helix forming oligonucleotide directed against androgen receptor. Chin Med J (Engl). 2008;121(22):2284-9.
  40. Zhao ZF, Gao GQ, Liu S, Zou JT, Xie Y, Yuan QF, et al. Screening for a human single chain Fv antibody against epitope on amyloid-beta 1 - 40 from a human phage display library. Chin Med J (Engl). 2007;120(21):1931-4.

教材专著

参编《人体形态学》，2012年，第2版，周福祥主编，人民卫生出版社。

科研项目

  1. 广东省自然科学基金-面上项目(2022A1515010690), 环状RNA has_circ_0001946介导miR-135a-5p调控Wnt/β-catenin通路促进小鼠中枢神经发生研究。
  2. 广东省自然科学基金-面上项目(2016A030313253), IFN-γ介导Wnt7a通路调控卡介苗促新生期神经发育的机制。
  3. 广东省自然科学基金-面上项目(2015A030313153)，免疫介导ERK1/2-p35-Cdk5通路调控卡介苗促新生期神经发育的机制。（粤科规财字[2015]120号）
  4. 中央高校基本科研业务费专项资金资助,新生期接种卡介苗和乙肝疫苗对小鼠认知能力及中枢神经发育的影响。
  5. 国家自然科学基金（81000545），自身抗原Aβ特异性T细胞介导神经元新生的实验证据。
  6. 中国博士后基金一等资助（20080440120），重组四价Aβ1-15腺病毒老年性痴呆疫苗接种成年恒河猴的免疫效应及安全性研究。
  7. 教育部高等学校博士学科点专项科研基金（20090171120047），Aβ自身抗原特异性T细胞介导神经新生治疗老年性痴呆实验研究。
  8. 广东省自然科学基金（9451008901002145），Aβ自身抗原特异性T细胞介导神经新生的实验证据。
  9. 广东省卫生厅医学科研基金（B2010066），Aβ自身抗原特异性T细胞介导神经新生的实验证据。
  10. 广州市科技计划项目（10C32060117），Aβ自身抗原特异性T细胞介导神经新生的实验证据。

获奖荣誉

  1. 广东医学科技奖二等奖，接种BCG和流感疫苗促进神经和认知发育及预防自闭症的作用和机制（GDMA202002202），第四（姚志彬，祁方昉，杨俊华，邹俊涛，郭凯华，夏宇岑，李清清，左泽杰）。

学术兼职

国家自然科学基金初审评委、广东省及广州市科研项目评委、中山大学学报（医学科学版）、实用医学杂志、现代医院、解剖学研究等杂志编辑、审稿人。广东省医养结合学会副会长、广东省神经科学学会支部书记及副秘书长。