博彩公司排名

个人简介

医学博士，博彩公司排名-博彩公司评级 药理病生系教授，硕士生导师，博士生导师， 2005年于首都医科大学获得临床医学学士学位，2010年于博彩公司排名-博彩公司评级 获得医学博士学位。兼任BMC Anesthesiology副编辑，广东省精准医学应用学会免疫治疗分会常务委员和广东省抗癌协会专业委员会委员，人民卫生出版社《药理学》教材配套《学习指导与习题集》编委。曾获中国药理学会全国青年教师教学竞赛一等奖。

研究领域为肿瘤药理，主要研究方向为溶瘤病毒疗法和实体瘤诱导分化疗法的基础研究和新药临床转化。目前的主要发现包括：鉴定阻碍溶瘤病毒M1抗肿瘤效应的免疫抑制细胞亚型和功能分子，发现基于以上机理的M1增效药物；提出反沃伯格效应在诱导恶性胶质瘤分化中的代谢重构机理，发现新的干预靶点和药物；解析恶性胶质瘤分化的组蛋白乙酰化密码，发现基于染色体重塑机理的诱导分化联合药物策略。

已获得国家自然科学基金4项、省科技厅应用型科研重大专项1项、省自然科学基金4项等共10余个项目的支持。已发表SCI科研论文60余篇 (作为第一或共同第一作者11 篇，作为通讯或共同通讯作者13篇)，发表在Oncogene、 Cell Reports、International Journal of Cancer、Molecular Oncology、Cell Death & Disease、Human Gene Therapy等杂志，2次参编英文脑肿瘤专著。

代表性论著

1. Xincheng Liu, Cui Gu, Tiandong Len, Zhen Fan, Jialuo Ma, Jiehong Chen, Jinhai Xu, Qianyi Li, Bin Jian, Ke Sai, Wenzhuo Yang, Jiayu G, Jingyi Wang, Shuxin Su, Zhijie Che, Yingqian Zhong, Xuanming Liang, Chaoxin Chen, Jing Cai, Yuan Lin, Jiankai Liang, Jun H, Guangmei Yan, Wenbo Zhu* and Wei Yin*. Differential regulation of H3K9/H3K14 acetylation by small molecules drives neuron-fate-induction of glioma cell. Cell Death Dis. 2023, 14: 142. （中科院1区TOP）
2. Jiayu Zhang#, Ying Liu#, Jingyi Tan, Yanming Zhang, Chunwa Wong, Ziqing Lin, Xincheng Liu, Max Sander, Xiaozhi Yang, Lebin Liang, Deli Song, Jia Dan, Yuwei Zhou, Jing Cai, Yuan Lin, Jiankai Liang, Jun Hu, Guangmei Yan, Wenbo Zhu*. Necroptotic Virotherapy of Oncolytic Alphavirus M1 cooperated with Doxorubicin displays promising therapeutic efficacy in TNBC. Oncogene. 2021, 40:4783–4795.（中科院1区TOP）
3. Fan Xing#, Yizhao Luan#, Jing Cai, Sihan Wu, Jialuo Mai, Jiayu Gu, Haipeng Zhang, Kai Li, Yuan Lin, Xiao Xiao, Jiankai Liang, Yuan Li, Wenli Chen, Yaqian Tan,Longxiang Sheng, Bingzheng Lu, Wanjun Lu, Mingshi Gao，Pengxin Qiu, Xingwen Su,Wei Yin, Jun Hu, Zhongping Chen, Ke Sai , Jing Wang, Furong Chen, Yinsheng Chen, Shida Zhu， Dongbing Liu, Shiyuan Cheng, Zhi Xie*, Wenbo Zhu*, Guangmei Yan*. Anti-Warburg Effect Elicited by cAMP-PGC1α Pathway Drives Differentiation of Glioblastoma Cells into Astrocytes. Cell Reports, 2017, 18 (2): 468-481. （中科院1区TOP）
4. Wenfeng Liu, Yang Liu, Cheng Hu, Cuiying Xu, Jiehong Chen, Yinting Chen, Jing Cai, Guangmei Yan, Wenbo Zhu*. CTLA-4 Antibody Aggrandizes Antitumor Immune Response of Oncolytic Virus M1 via Targeting Regulatory T Cells. Int. J. Cancer. 2021, 149 (6): 1369-1384.（中科院1区TOP）
5. Shuxin Sun#, Dongdong Xue#, Zhijie Chen, Ying Ou-yang, Ji Zhang, Jialuo Mai, Jiayv Gu, Wanjun Lu, Xincheng Liu, Wenfeng Liu, Longxiang Sheng, Bingzheng Lu, Yuan Lin, Fan Xing, Zhongping Chen, Yonggao Mou, Guangmei Yan, Wenbo Zhu*& Ke Sai*. R406 elicits anti-Warburg effect via Syk-dependent and -independent mechanisms to trigger apoptosis in glioma stem cells. Cell Death & Disease, 2019, 10(358): 1-16. （中科院1区TOP）
6. Wenbo Zhu, Jiankai Liang, Jingyi Tan, Li Guo, Jing Cai, Jun Hu, Guangmei Yan, Yang Liu, Jiayu Zhang, Deli Song, Jia Dan, Chun-Wa Wong, Xingwen Su, Pengxin Qiu, and Yuan Lin*. "Real-Time Visualization and Quantification of Oncolytic M1 Virus In Vitro and In Vivo." Hum Gene Ther. 2021, 32(3-4): 158-165. （中科院2区，封面文章）