个人简介

李伟强博士，博彩公司排名-博彩公司评级 教授，博士生导师。本硕博均毕业于中山大学，2009年获得干细胞与组织工程博士学位。以通讯作者或第一作者（含共同）在Cell Res、Cell Rep Med、Nat Commun等杂志发表SCI论文20篇。先后主持国家自然科学基金项目6项、广东省重点领域项目及广州市协同创新重大项目3项。获得授权国际发明专利4项、授权国内发明专利8项。曾入选广东特支计划百千万工程青年拔尖人才培养计划、广州市“珠江科技新星”等人才培养计划。

导   师：博士生导师

学科专业：干细胞与再生医学

重要学术成果与贡献

神经嵴可分化为外胚层的外周神经组织、黑色素细胞及中胚层的骨/软骨、周细胞等，在不同组织器官的发育成熟、功能维持及再生修复中发挥了重要作用，其机制远未阐明。李伟强博士长期从事多能干细胞向神经嵴诱导分化的分子机制及转化研究。以人多能干细胞为体外细胞模型，揭示了神经嵴早期发育和迁移的相关调控机制，建立了神经嵴起源肠道神经元、交感神经元、周细胞等的高效诱导体系并开展移植疗效评估，提出了神经嵴相关疾病（腓骨肌萎缩、唐氏综合征等）的新的发病机理。相关研究结果有助于深入理解神经嵴在组织器官发育和疾病发病机制中的作用，也为推动神经嵴在组织损伤修复中的转化应用提供了新的思路。

学术论著与教材

发表论文（仅列出通讯作者和第一作者论文，*共同通讯作者，#共同第一作者）：

  1. Fan Y#, Huang S#, Li S#, Wu B, Zhao Q, Huang L, Zheng Z, Xie X, Liu J, Huang W, Sun J, Zhu X*, Zhu J*, Xiang AP*, Li W*. The adipose-neural axis is involved in epicardial adipose tissue-related cardiac arrhythmias. Cell Rep Med. 2024 May 21;5(5):101559.
  2. Liu H#, Huang S#, Wang W#, Wang H, Huang W, Zhai Z, Wang D, Fan Y, Sun J, Li D, Chiu W, Lai X, Zeng J, Ke Q, Wang T, Xiang AP, Yuan Y*, Zhang X*, Li W*. Migration deficits of the neural crest caused by CXADR triplication in a human Down syndrome stem cell model. Cell Death Dis. 2022 Dec 5;13(12):1018.
  3. Wei Y#, Wang B#, Jia L#, Huang W, Xiang AP, Fang C*, Liang X*, Li W*. Lateral mesoderm-derived mesenchymal stem cells with robust osteochondrogenic potential and hematopoiesis-supporting ability. Front Mol Biosci. 2022 Apr 28;9:767536. 
  4. Sun J#, Huang Y#, Gong J#, Wang J, Fan Y, Cai J, Wang Y, Qiu Y, Wei Y, Xiong C, Chen J, Wang B, Ma Y, Huang L, Chen X, Zheng S, Huang W, Ke Q, Wang T, Li X, Zhang W, Xiang AP*, Li W*. Transplantation of hPSC-derived pericyte-like cells promotes functional recovery in ischemic stroke mice. Nat Commun. 2020 Oct 15;11(1):5196. 
  5. Wang H#, Li D#, Zhai Z#, Zhang X, Huang W, Chen X, Huang L, Liu H, Sun J, Zou Z, Fan Y, Ke Q, Lai X, Wang T, Li X, Shen H, Xiang AP*, Li W*. Characterization and Therapeutic Application of Mesenchymal Stem Cells with Neuromesodermal Origin from Human Pluripotent Stem Cells. Theranostics. 2019; 9(6):1683-1697.
  6. Li W#, Huang L#, Zeng J#, Lin W, Li K, Sun J, Huang W, Chen J, Wang G, Ke Q, Duan J, Lai X, Chen R, Liu M, Liu Y, Wang T, Yang X, Chen Y, Xia H*, Xiang AP*. Characterization and transplantation of enteric neural crest cells from human induced pluripotent stem cells. Mol Psychiatry. 2018 Mar;23(3):499-508.
  7. Xiang Q#, Liao Y#, Chao H#, Huang W, Liu J, Chen H, Hong D, Zou Z, Xiang AP, Li W. ISL1 overexpression enhances the survival of transplanted human mesenchymal stem cells in a murine myocardial infarction model. Stem Cell Res Ther. 2018 Feb 26;9(1):51.
  8. Shi L#, Huang L#, He R#, Huang W, Wang H, Lai X, Zou Z, Sun J, Ke Q, Zheng M, Lu X, Pei Z, Su H, Xiang AP, Li W*, Yao X. Modeling the Pathogenesis of Charcot-Marie-Tooth Disease Type 1A Using Patient-Specific iPSCs. Stem Cell Reports. 2018 Jan 9; 10(1):1-14. 
  9. Ke Q#, Li L#, Yao X#, Lai X, Cai B, Chen H, Chen R, Zhai Z, Huang L, Li K, Hu A, Mao FF, Xiang AP, Tao L*, Li W*. Enhanced generation of human induced pluripotent stem cells by ectopic expression of Connexin 45. Sci Rep. 2017 Mar 28;7(1):458. 
  10. Ke Q#, Li W#, Lai X#, Chen H, Huang L, Kang Z, Li K, Ren J, Lin X, Zheng H, Huang W, Ma Y, Xu D, Chen Z, Song X, Lin X, Zhuang M, Wang T, Zhuang F, Xi J, Mao FF, Xia H, Lahn BT, Zhou Q*, Yang S*, Xiang AP*. TALEN-based generation of a cynomolgus monkey disease model for human microcephaly. Cell Res. 2016 Sep;26(9):1048-61. 
  11. Hu X#, Xie P#, Li W#, Li Z, Shan H*. Direct induction of hepatocyte-like cells from immortalized human bone marrow mesenchymal stem cells by overexpression of HNF4α. Biochem Biophys Res Commun. 2016 Sep 16;478(2):791-7. 
  12. Yan S#, Li P#, Wang Y#, Yu W, Qin A, Liu M, Xiang AP, Zhang W*, Li W*. Nestin regulates neural stem cell migration via controlling the cell contractility. Int J Biochem Cell Biol. 2016 Sep;78:349-60. 
  13. Li W#, Huang LH#, Lin WY#, Ke Q, Chen R, Lai XQ, Wang XY, Zhang JF, Jiang MH, Huang WJ, Wang T, Yang XS, Chen Y, Song W, Xiang AP*. Engraftable neural crest stem cells derived from cynomolgus monkey embryonic stem cells. Biomaterials, 2015 Jan;39:75-84. 
  14. Liu J#, Li W, Wang Y, Fan W, Li P, Lin W, Yang D, Fang R, Feng M, Hu C, Du Z, Wu G*, Xiang AP*. Islet-1 overexpression in human mesenchymal stem cells promotes vascularization through monocyte chemoattractant protein-3. Stem Cells. 2014 Jul;32(7):1843-54.
  15. Li W*, Xiang AP*. Safeguarding clinical translation of pluripotent stem cells with suicide genes. Organogenesis. 2013 Jan-Mar;9(1):34-9. （第一作者、共同通讯作者）IF2.316
  16. Cheng F#, Ke Q#, Chen F#, Cai B, Gao Y, Ye C, Wang D, Zhang L, Lahn BT, Li W*, Xiang AP*. Protecting against wayward human induced pluripotent stem cells with a suicide gene. Biomaterials. 2012 Apr;33(11):3195-204. 
  17. Yao XL#*, Liu Q#, Ye CH, Li ZP, Lu XL, Li PL, Li XB, Li W*. Neuronal differentiation potential of mouse induced pluripotent stem cells. Neuroreport. 2011 Oct 5; 22(14):689-95. 
  18. Qin J#, Li W#, Zhang L, Chen F, Liang WH, Mao FF, Zhang XM, Lahn BT, Yu WH*, Xiang AP*. A stem cell-based tool for small molecule screening in adipogenesis. PLoS One. 2010 Sep27; 5 (9): e13014.
  19. Li W#, Liu C#, Qin J, Zhang L, Chen R, Chen J, Yu X, Wu G, Lahn BT, Fu Y, Xiang AP. Efficient genetic modification of cynomolgus monkey embryonic stem cells with lentiviral vectors. Cell transplant. 2010; 19(9):1181-93.
  20. Li W#, Wang D#, Qin J, Liu C, Zhang Q, Zhang X, Yu X, Lahn BT, Mao FF, Xiang AP. Generation of functional hepatocytes from mouse induced pluripotent stem cells. J Cell Physiol. 2010 Mar; 222(3): 492-501.

获奖及荣誉

2021 广东省自然科学一等奖 第二完成人
2021 广东医学科技奖一等奖 第二完成人
2018 中华医学科技奖青年科技奖 第二完成人

学术兼职

广东省医学会细胞治疗学分会委员兼秘书
广东省生殖医学重点实验室副主任
中国卒中学会脑小血管病分会常委
中华医学会医学细胞生物学分会第六届委员会青年委员

主持的科研项目

  1. 国家自然科学基金面上项目，2025-2028
  2. 国家自然科学基金面上项目，2023-2026
  3. 国家自然科学基金面上项目，2020-2023
  4. 国家自然科学基金面上项目，2016-2019
  5. 国家重点研发计划，2021-2026，项目骨干
  6. 国家重点研发计划，2017-2021，项目骨干
  7. 广东省重点领域研发计划项目，2019-2021