个人简介

钟小敏，博士，博彩公司排名-博彩公司评级 副教授，博士生导师，中山大学百人计划引进人才。本科毕业于中山大学，博士毕业于中国科学院上海生命科学研究院健康科学研究所，并于美国University of Pennsylvania进行博士后研究工作。

主要研究方向为非编码RNA在肿瘤生物学中的功能研究，以及非编码RNA在干细胞的维持、诱导分化和重编程中的作用机理。在教学工作中，主讲医学研究生《干细胞与组织工程研究进展》理论课程，以及医学本科生《医学细胞生物学》的理论与实验课程。至今已在权威期刊上发布多篇相关领域研究文章及综述，作为项目负责人主持国家重点研发计划、国家自然科学基金、广东省科技计划及广州市科技计划等项目。

学术成果

  1. Peng L, Shi Y, Deng J, Chen J, Xiang P, Zhong X*. DANCR maintained colon epithelial homeostasis by regulating the TNFα/NF-κB pathway. Biochem Biophys Res Commun. 2024 Sep 3:723:150176. (*Corresponding author)
  2. Jiacheng Deng, Limei Peng, Yingpeng Shi, Xiaomin Zhong*. DANCR Regulates hESC Differentiation Towards Definitive Endoderm. Journal of Sun Yat-Sen University (Medical Sciences). 2024 Vol. 45 (1): 45-53. (*Corresponding author)
  3. Minmin Xiong, Mengshi Wu, Dan Peng, Weijun Huang, Zehong Chen, Haoxian Ke, Zewen Chen, Wu Song, Yonghua Zhao, Andy P Xiang, Xiaomin Zhong*. LncRNA DANCR represses Doxorubicin-induced apoptosis through stabilizing MALAT1 expression in colorectal cancer cells. Cell Death Dis. 2021 Jan 6;12(1):24. (*Corresponding author)
  4. Mengshi Wu, Minmin Xiong, Dan Peng, Xue Han, Xiaomin Zhong*. MS2-RIP Assay for Identifying the Interaction Partners of lncRNA DANCR in Tumor Cells. Journal of Sun Yat-Sen University (Medical Sciences). 2021 Vol. 42 (1): 24-32. (*Corresponding author)
  5. Lin X, Yang F, Qi X, Li Q, Wang D, Yi T, Yin R, Zhao X, Zhong X*, Bian C*. LncRNA DANCR promotes tumor growth and angiogenesis in ovarian cancer through direct targeting of miR-145. Mol Carcinog. 2019;58:2286–2296. (*Co-corresponding authors)
  6. Dan Peng, Xiaomin Zhong*. Stable Knockout of lncRNA DANCR Gene in Mesenchymal Stem Cells with a Dual-Target CRISPR Lentiviral Vector. Journal of Sun Yat-Sen University (Medical Sciences). 2019 Vol. 40 (1): 14-22. (*Corresponding author)
  7. Zhang L, Peng D, Sood AK, Dang CV, Zhong X*. Shedding Light on the Dark Cancer Genomes: Long Noncoding RNAs as Novel Biomarkers and Potential Therapeutic Targets for Cancer. Mol Cancer Ther. 2018 Sep;17(9):1816-1823. Review. (*Corresponding author)
  8. Lin X, Shen J, Peng D, He X, Xu C, Chen X, Tanyi JL, Montone K, Fan Y, Huang Q, Zhang L, Zhong X*. RNA-binding protein LIN28B inhibits apoptosis through regulation of the AKT2/FOXO3A/BIM axis in ovarian cancer cells. Signal Transduct Target Ther. 2018 Aug 31;3:23. (*Corresponding author)
  9. Zhong X*, Zhang D, Xiong M, Zhang L. Noncoding RNA for Cancer Gene Therapy. Recent Results Cancer Res. 2016;209:51-60. (*Corresponding author)
  10. Zhong X*, Zheng L, Shen J, Zhang D, Xiong M, Zhang Y, He X, Tanyi JL, Yang F, Montone KT, Chen X, Xu C, Xiang AP, Huang Q, Xu X, Zhang L*. Suppression of MicroRNA 200 Family Expression by Oncogenic KRAS Activation Promotes Cell Survival and Epithelial-Mesenchymal Transition in KRAS-Driven Cancer. Mol Cell Biol. 2016 Oct 13;36(21):2742-2754. (*Corresponding authors)
  11. Zhang D, Xiong M, Xu C, Xiang P, Zhong X*. Long Noncoding RNAs: An Overview. Methods Mol Biol. 2016;1402:287-95. (*Corresponding author)
  12. Zhong X*, Hu X, Zhang L. Oncogenic long noncoding RNA FAL1 in human cancer. Mol Cell Oncol. 2015 Feb 25;2(2):e977154. (*Corresponding author)
  13. Yang X#, Zhong X#, Tanyi JL, Shen J, Xu C, Gao P, Zheng TM, Demichele AM, Zhang L. mir-30d regulates multiple genes in the autophagy pathway and impairs autophagy process in human cancer cells. Biochem Biophys Res Commun. 2013 Feb 15;431(3):617-22. (#Co-first author)
  14. Zhong X, Coukos G, Zhang L. miRNAs in human cancer. Methods Mol Biol. 2012;822:295-306.
  15. Zhong X, Li N, Liang S, Huang Q, Coukos G, Zhang L. Identification of microRNAs regulating reprogramming factor LIN28 in embryonic stem cells and cancer cells. J Biol Chem. 2010 Dec 31;285(53):41961-71.
  16. Zhong X, Jin Y. Critical roles of coactivator p300 in mouse embryonic stem cell differentiation and Nanog expression. J Biol Chem. 2009 Apr 3;284(14):9168-75.
  17. Hu Z, Zhou J, Jiang J, Yuan J, Zhang Y, Wei X, Loo N, Wang Y, Pan Y, Zhang T, Zhong X, Long M, Montone KT, Tanyi JL, Fan Y, Wang TL, Shih IM, Hu X, Zhang L. Genomic Characterization of Genes Encoding Histone Acetylation Modulator Proteins Identifies Therapeutic Targets for Cancer Treatment. Nat Commun. 2019 Feb 13;10(1):733. 
  18. Yuan J, Hu Z, Mahal BA, Zhao SD, Kensler KH, Pi J, Hu X, Zhang Y, Wang Y, Jiang J, Li C, Zhong X, Montone KT, Guan G, Tanyi JL, Fan Y, Xu X, Morgan MA, Long M, Zhang Y, Zhang R, Sood AK, Rebbeck TR, Dang CV, Zhang L. Integrated Analysis of Genetic Ancestry and Genomic Alterations across Cancers. Cancer Cell 2018 Oct 8;34, 549–560.
  19. Zhang D, Zhang G, Hu X, Wu L, Feng Y, He S, Zhang Y, Hu Z, Yang L, Tian T, Xu W, Wei Z, Lu Y, Flaherty KT, Zhong X, Mills GB, Gimotty PA, Xu X, Herlyn M, Zhang L. Oncogenic RAS Regulates Long Noncoding RNA Orilnc1 in Human Cancer. Cancer Res. 2017 Jul 15;77(14):3745-3757.
  20. Hu X, Feng Y, Zhang D, Zhao SD, Hu Z, Greshock J, Zhang Y, Yang L, Zhong X, Wang LP, Jean S, Li C, Huang Q, Katsaros D, Montone KT, Tanyi JL, Lu Y, Boyd J, Nathanson KL, Li H, Mills GB, Zhang L. A Functional Genomic Approach Identifies FAL1 as an Oncogenic Long Noncoding RNA that Associates with BMI1 and Represses p21 Expression in Cancer. Cancer Cell. 2014 Sep 8;26(3):344-57.
  21. Liao B, Zhong X, Xu H, Xiao F, Fang Z, Gu J, Chen Y, Zhao Y, Jin Y. Itch, an E3 Ligase of Oct4, Is Required for Embryonic Stem Cell Self-Renewal and Pluripotency Induction. J Cell Physiol. 2013 Jul;228(7):1443-51.
  22. Li N, Zhong X, Lin X, Guo J, Zou L, Tanyi JL, Shao Z, Liang S, Wang LP, Hwang WT, Katsaros D, Montone K, Zhao X, Zhang L. lin-28 homologue A (LIN28A) promotes cell cycle progression via the regulation of cyclin-dependent kinase 2 (CDK2), cyclin D1 (CCND1), and cell division cycle 25 homolog A (CDC25A) expression in cancer. J Biol Chem. 2012 May 18;287(21):17386-97.
  23. Li N, Kaur S, Greshock J, Lassus H, Zhong X, Wang Y, Leminen A, Shao Z, Hu X, Liang S, Katsaros D, Huang Q, Bützow R, Weber BL, Coukos G, Zhang L. A combined array-based comparative genomic hybridization and functional library screening approach identifies mir-30d as an oncomir in cancer. Cancer Res. 2012 Jan 1;72(1):154-64.
  24. Yang X, Lin X, Zhong X, Kaur S, Li N, Liang S, Lassus H, Wang L, Katsaros D, Montone K, Zhao X, Zhang Y, Bützow R, Coukos G, Zhang L. Double-negative feedback loop between reprogramming factor LIN28 and microRNA let-7 regulates aldehyde dehydrogenase 1-positive cancer stem cells. Cancer Res. 2010 Nov 15;70(22):9463-72.

科研项目

  1. GVHD靶向防治的临床级MSC制备和生物学效能评估体系的建立 (国家重点研发计划，课题负责人)
  2. Exosome介导的microRNA let-7靶向治疗卵巢癌的实验研究 (国家自然科学基金, 项目负责人)
  3. Neuropilin-1在诱导多能干细胞产生中的功能及机理研究 (广东省科技计划，项目负责人)
  4. 乳腺癌转移相关的环状RNA鉴定及其作用机理探讨 (广州市科技计划，项目负责人)
  5. “MSC”方案治疗GVHD的前瞻性、多中心、开放、随机对照临床研究 (广东省科技计划，项目参与人)