个人简介

袁洁，理学博士，博彩公司排名-博彩公司评级 副教授，硕士生导师。本科及研究生毕业于中山大学，获生化与分子生物学博士学位。

一直从事海洋天然产物活性分子筛选和新型抗肿瘤、抗病毒药物靶点及分子机制的研究工作。主要研究兴趣关注于：（1）新型抗肿瘤、抗病毒药物靶点研究：以重要的肿瘤信号通路为线索，探索新型的抗肿瘤、抗病毒药物靶点，进而对其抗肿瘤机制进行深入研究。（2）海洋活性分子药物筛选：以新型靶点分子、病毒、肿瘤细胞和模式生物为筛选模型，以海洋小分子天然产物库为基础，进行抗肿瘤、抗病毒海洋新药研发。从分子水平、细胞水平和动物水平进行全面的药效学评价和分子机制研究。发现了一系列具有显著的抗肿瘤、抗病毒活性的海洋来源的先导化合物。

作为项目主持人承担了国家863项目，国家自然青年基金，广东省自然科学基金等，作为研究骨干参与了多项国家自然基金、国家新药创制重大专项、广东省科技计划重大项目、海洋公益性行业科研专项、海洋经济创新发展区域示范项目的研究工作。以通讯作者（含共同）或第一作者身份在Brit J Pharmacology、BMC Medicine、Eur J Med Chem、Mar Drugs、Antiviral Res、Bioorg Chem等专业期刊发表多篇学术论文。

学术成果

  1. Zhang K, Liang J, Zhang B, Huang L, Yu J, Xiao X, He Z*, Tao H*, Yuan J*: A Marine Natural Product, Harzianopyridone, as an Anti-ZIKV Agent by Targeting RNA-Dependent RNA Polymerase. Molecules 2024, 29(5).
  2. Chen Y, Yang W, Zhu G, Wang G, Chen T, Li H, Yuan J*, She Z*: Didymorenloids A and B, two polycyclic cyclopenta[b]fluorene-type alkaloids with anti-hepatoma activity from the mangrove endophytic fungus Didymella sp. CYSK-4. Organic Chemistry Frontiers 2024. 
  3. Yang W, Zhang B, Tan Q, Chen Y, Chen T, Zou G, Sun B, Wang B, Yuan J*, She Z*: 4-Hydroxy-2-pyridone derivatives with antitumor activity produced by mangrove endophytic fungus Talaromyces sp. CY-3. Eur J Med Chem 2024, 269:116314. 
  4. Zhu, Y; Yu, J; Chen, T; Liu, W; Huang, Y; Li, J; Zhang, B; Zhu, G; He, Z*; Long, Y*; Yuan, J*, Design, synthesis, and biological evaluation of a series of new anthraquinone derivatives as anti-ZIKV agents. Eur J Med Chem 2023, 258, 115620. 
  5. Zhu, Y; Liang, M; Yu, J; Zhang, B; Zhu, G; Huang, Y; He, Z*; Yuan, J*, Repurposing of Doramectin as a New Anti-Zika Virus Agent. Viruses 2023, 15, (5). 
  6. Huang, Y; Huang, Y; Zhu, G; Zhang, B; Zhu, Y; Chen, B*; Gao, X*; Yuan, J*, A Meroterpenoid from Tibetan Medicine Induces Lung Cancer Cells Apoptosis through ROS-Mediated Inactivation of the AKT Pathway. Molecules 2023, 28, (4). 
  7. Yao, G; Yu, J; Lin, C; Zhu, Y; Duan, A; Li, M; Yuan, J*; Zhang, J*, Design, synthesis, and biological evaluation of novel 2'-methyl-2'-fluoro-6-methyl-7-alkynyl-7-deazapurine nucleoside analogs as anti-Zika virus agents. Eur J Med Chem 2022, 234, 114275. 
  8. Jiang, H; Cai, R; Zang, Z; Yang, W; Wang, B.; Zhu, G; Yuan, J*; She, Z*, Azaphilone derivatives with anti-inflammatory activity from the mangrove endophytic fungus Penicillium sclerotiorum ZJHJJ-18. Bioorg Chem 2022, 122, 105721. 
  9. Zheng, Y, Pei, Y, Yang, L, Zeng, Z, Wang, J, Xie, G, Wang, L*, Yuan, J*. Upregulated GRB7 promotes proliferation and tumorigenesis of Bladder Cancer via Phospho-AKT Pathway. Int J Biol Sci 2020, 16, (16), 3221-3230. 
  10. Wang, L, Huang, Y, Huang, C. H, Yu, J. C, Zheng, Y. C, Chen, Y, She, Z*, Yuan, J*. A Marine Alkaloid, Ascomylactam A, Suppresses Lung Tumorigenesis via Inducing Cell Cycle G1/S Arrest through ROS/Akt/Rb Pathway. Mar Drugs 2020, 18, (10). 
  11. Yuan, J#, Yu, J#, Huang, Y, He, Z, Luo, J, Wu, Y, Zheng, Y, Wu, J, Zhu, X, Wang, H, Li, M., Antibiotic fidaxomicin is an RdRp inhibitor as a potential new therapeutic agent against Zika virus. BMC Medicine 2020, 18, (1), 204.
  12. Chen Y, Liu Z, Huang Y, Liu L, He J, Wang L, Yuan J*, She Z*. Ascomylactams A-C, Cytotoxic 12- or 13-Membered-Ring Macrocyclic Alkaloids Isolated from the Mangrove Endophytic Fungus Didymella sp. CYSK-4, and Structure Revisions of Phomapyrrolidones A and C." J Nat Prod. 2019. 82(7): 1752-1758. 
  13. Lin C, Yu J, Hussain M, Zhou Y, Duan A, Pan W, Yuan J*, Zhang J*. Design, synthesis, and biological evaluation of novel 7-deazapurine nucleoside derivatives as potential anti-dengue virus agents. Antiviral Res. 2018 Jan;149:95-105. 
  14. Huang Y, Yang L, Pei YY, Wang J, Wu H, Yuan J*, Wang L*. Overexpressed ACBD3 has prognostic value in human breast cancer and promotes the self-renewal potential of breast cancer cells by activating the Wnt/beta-catenin signaling pathway. Exp Cell Res. 2018 Feb 1;363(1):39-47.
  15. Cui H, Yu J, Chen S, Ding M, Huang X, Yuan J*, She Z*. Alkaloids from the mangrove endophytic fungus Diaporthe phaseolorum SKS019. Bioorg Med Chem Lett. 2017 Feb 15;27(4):803-807. 
  16. Hu Y, Chen J, Hu G, Yu J, Zhu X, Lin Y, Chen S, Yuan J*. Statistical research on the bioactivity of new marine natural products discovered during the 28 years from 1985 to 2012. Mar Drugs. 2015 Jan 7;13(1):202-21. 
  17. Xiong H, Wang J, Guan H, Wu J, Xu R, Wang M, Rong X, Huang K, Huang J, Liao Q, Fu Y, Yuan J*. SphK1 confers resistance to apoptosis in gastric cancer cells by downregulating Bim via stimulating Akt/FoxO3a signaling. Oncol Rep. 2014 Aug 7. doi: 10.3892/or.2014.3391. 
  18. Xie G, Zhu X, Qing Li, He Z, Wu J, Li J, Lin Y, Li M, She Z, Yuan J*.SZ-685C, a marine anthraquinone, as a potent apoptosis inducer with anticancer activity through suppressing the Akt/FOXO pathway. British J Pharmacology. 2010 Feb 1;159(3):689-97. 

教材专著

主编出版了2部国家规划教材：

  1. 十三五规划教材，《生物化学学习指导及习题集》第四版，人卫出版社，2019年。
  2. 十四五规划教材，《生物化学学习指导及习题集》第五版，人卫出版社，2023年。

副主编出版了3部教材：

  1. 《精编速览生物化学与分子生物学》，中国医药科技出版社，2018年。
  2. 《同步习题集生物化学与分子生物学》，中国医药科技出版社，2018年。
  3. 《分子生物学经典理论与实用技术》，人卫出版社，2024年。

科研项目

  1. 国家863项目，2007至2010
  2. 国家自然科学基金，2009至2011
  3. 广东省自然科学基金，2009至2010；2022至2024