导师资格：博士生导师

所在教研室/单位： 生物化学与分子生物学教研室

E-mail：[email protected]

通信地址： 广州中山二路74号博彩公司排名-博彩公司评级 生物化学与分子生物学教研室

办公电话：02087330928-828

研究方向：脑卒中等中枢神经系统疾病脑损伤机制及其药物研发

个人简介

研究工作简介

研究方向为脑卒中、老年痴呆和胶质瘤等重大神经系统疾病的脑损伤机制与药物研发。研究近年集中于糖代谢关键酶对脑组织的损伤作用，发现新的脑卒中药物靶点己糖激酶2（HK2），并展开HK2促进炎症、外泌体生成等脑损伤机制探索；承担1.1类急性缺血性脑卒中新药YC-6（已进入II期临床试验）的临床前药效学与神经保护机制的研究，主持实施了YC-6及其同系物预防急性高原性脑损伤等其他适应症应用的研究；作为十一五重大新药创制负责人，主持了抗脑缺血基因工程直接溶栓药物研发。此外，还参与恶性实体瘤的诱导分化治疗研究，发现生物毒素、小分子及其组合物诱导胶质瘤细胞分化的作用，并展开恶性胶质瘤诱导分化治疗及其分子机制研究。

学术成果

发表的论文

  1. Xincheng Liu, Cui Guo, Tiandong Leng, Zhen Fan, Jialuo Mai, Jiehong Chen, Jinhai Xu, Qianyi Li, Bin Jiang, Ke Sai, Wenzhuo Yang, Jiayu Gu, Jingyi Wang, Shuxin Sun, Zhijie Chen, Yingqian Zhong, Xuanming Liang, Chaoxin Chen, Jing Cai, Yuan Lin, Jiankai Liang, Jun Hu, Guangmei Yan, Wenbo Zhu* and Wei Yin* , Differential regulation of H3K9/H3K14 acetylation by small molecules drives neuron-fate-induction of glioma cell. Cell Death and Disease,  2023, 14(2):142.  
  2. Chen Chen, YuWei Zhou, XinPeng Ning, ShengLong Li, DongDong Xue, CaiLv Wei, Zhu Zhu, LongXiang Sheng, BingZheng Lu, Yuan Li, XiaoYuan Ye, YunZhao Fu, Chuan Bai, Wei Cai, YuXuan Ding, SuiZhen Lin, GuangMei Yan, YiJun Huang* and Wei Yin*，Directly targeting ASC by lonidamine alleviates inflammasome-driven diseases, Journal of Neuroinflammation，2022，19(1)：315.  
  3. DongDong Xue, CaiLv Wei, YueHan Zhou, Kai Wang, YuWei Zhou, Chen Chen, Yuan Li, LongXiang Sheng, BingZheng Lu, Zhu Zhu, Wei Cai, XinPeng Ning, ShengLong Li, TianYu Qi, JiaKai Pi, SuiZhen Lin, GuangMei Yan, YiJun Huang*, and Wei Yin*, TRIOL Inhibits Rapid Intracellular Acidification and Cerebral Ischemic Injury: The Role of Glutamate in Neuronal Metabolic Reprogramming, ACS Chemical Neuroscience, 2022, 13 (14):2110-2121. 
  4. Chen Z, Zhong Y, Chen J, Sun S, Liu W, Han Y, Liu X, Guo C, Li D, Hu W, Zhang P, Chen Z, Chen Z, Mou Y, Yan G, Zhu W*, Yin W*, Sai K*., Disruption of β-catenin-mediated negative feedback reinforces cAMP-induced neuronal differentiation in glioma stem cells, Cell Death and Disease，2022 May 24;13(5):493. 
  5. Zhu Z, Lu J, Wang S, Peng W, Yang Y, Chen C, Zhou X, Yang X, Xin W, Chen X, Pi J, Yin W*, Yao L*, Pi R*. Acrolein, an endogenous aldehyde induces synaptic dysfunction in vitro and in vivo: Involvement of RhoA/ROCK2 pathway. Aging Cell. 2022 Apr;21(4):e13587.
  6. Yang Y, Tu Y, Lu J, Chen Q, Zhu Z, Peng W, Zhu W, Wen S, Zhang J, Yin W*, Pi R.*, PT109, a novel multi-kinase inhibitor, suppresses glioblastoma multiforme through cell reprogramming: Involvement of PTBP1/PKM1/2 pathway. European Journal of Pharmacology, 2022, Vol 920, 174837. 
  7. Bingzheng Lu, Zhu Zhu, Longxiang Sheng, Yuan Li, Yang Yang, Yupin Chen, Dongdong Xue, Yuwei Zhou, Wei Cai, Chen Chen, Cailv Wei, Dong Xu, Min Yan, Suizhen Lin, Guangmei Yan, Wei Yin*, SMARCB1 Promotes Ubiquitination and Degradation of NR4A3 via Direct Interaction Driven by ROS in Vascular Endothelial Cell Injury, Oxidative Medicine and Cellular Longevity, 2020 Oct 23; 2020:2048210.
  8. Zhang P, Chen JS, Li QY, Sheng LX, Gao YX, Lu BZ, Zhu WB, Zhan XY, Li Y, Yuan ZB, Xu G, Qiu BT, Yan M, Guo CX, Wang YQ, Huang YJ, Zhang JX, Liu FY, Tang ZW, Lin SZ, Cooper DN, Yang HM, Wang J, Gao YQ*, Yin W*, Zhang GJ*, Yan GM*. Neuroprotectants attenuate hypobaric hypoxia-induced brain injuries in cynomolgus monkeys. Zoological Research, 2020 Jan 18;41(1):3-19.
  9. Sheng L, Lu B, Chen H, Du Y, Chen C, Cai W, Yang Y, Tian X, Huang Z, Chi W, Lin S, Yan G, Yin W.* Marine-Steroid Derivative 5α-Androst-3β, 5α, 6β-triol Protects Retinal Ganglion Cells from Ischemia–Reperfusion Injury by Activating Nrf2 Pathway. Marine Drugs. 2019; 17(5):267.
  10. Sun, H.-J.-Q.; Xue, D.-D.; Lu, B.-Z.; Li, Y.; Sheng, L.-X.; Zhu, Z.; Zhou, Y.-W.; Zhang, J.-X.; Lin, G.-J.; Lin, S.-Z.; Yan, G.-M.; Chen, Y.-P. *; Yin, W.* A Novel Synthetic Steroid of 2β,3α,5α-Trihydroxy-androst-6-one Alleviates the Loss of Rat Retinal Ganglion Cells Caused by Acute Intraocular Hypertension via Inhibiting the Inflammatory Activation of Microglia. Molecules , 2019, 24(2), 252.
  11. Li Y, Lu B, Sheng L, Zhu Z, Sun H, Zhou Y, Yang Y, Xue D, Chen W, Tian X, Du Y, Yan M, Zhu W, Xing F, Li K, Lin S, Qiu P, Su X, Huang Y, Yan G*, Yin W.* Hexokinase 2-dependent Hyperglycolysis Driving Microglial Activation Contributes to Ischemic Brain Injury. Journal of  Neurochemistry. 2018,144, 186--200.
  12. Yin W, Wang ZJ, Li QY, Lian JM, Zhou Y, Lu BZ, Jin LJ, Qiu PX, Zhang P, Zhu WB, Wen B, Huang YJ, Lin ZL, Qiu BT, Su XW, Yang HM, Zhang GJ, Yan GM, Zhou Q. Evolutionary trajectories of snake genes and genomes revealed by comparative analyses of five-pacer viper. Nature Communications, 2016 Oct 6;7:13107.
  13. Li Y#, Yin W#, Wang X, Zhu W, Huang Y, Yan G*. Cholera toxin induces malignant glioma cell differentiation via the PKA/CREB pathway. Proc Natl Acad Sci U S A. 2007, Aug 14;104(33):13438-43.

科研项目

  1. 国家自然科学基金，面上项目，No. 82071321，己糖激酶2通过蛋白激酶活性调节星形胶质细胞外泌体生成参与急性缺血性脑损伤，2021-01至2024-12，55万；
  2. 国家自然科学基金，面上项目，No. 81773711，糖酵解关键酶HK2在缺血性脑卒中的神经元损伤新角色，2018-01至2021-12，55万；
  3. 广东省省级科技计划项目，产业技术研究与开发专项，No. 20160909，新型溶瘤病毒M1的一步法纯化工艺研究，2016-08至2019/07，150万；
  4. 广州市科技计划项目产学研协同创新重大专项（民生科技研究），No. 201704020103, 新型小分子甾体预防急性低压缺氧脑损伤的临床前研究，2017/05至2020/04，400万；
  5. 国家自然科学基金项目，面上项目，No. 81470162，新型神经保护剂YC-6预防急性高原病的非人灵长类动物多组学研究，2015/01至2016/12，30万；
  6. 十一五科技部科技重大专项, “重大新药创制”， No.2009ZX09102-217, 直接溶栓药重组蛇毒纤溶酶II 的临床前研究（Ⅰ类新药）, 2010/01至2011/12，267万；
  7. 国家自然科学基金项目, 青年基金，No. 30700202, 泛素相互作用蛋白KIAA0280的基因敲除及其对神经元凋亡信号通路的调控, 2008/01至2010/12，17万。