博彩公司排名

个人简介

董俊超先后获得复旦大学生命科学院学士、得克萨斯大学圣安东尼奥健康科学中心博士学位，并在哈佛医学院从事博士后研究。获得国家高层次引进人才青年项目、广东省珠江人才计划创新创业团队和中山大学等项目支持，2017年起任博彩公司排名-博彩公司评级 教授，专注于淋巴细胞的发育、成熟和病变，重点以多组学方法研究表观调控和三维基因组结构影响淋巴细胞发育及血液系统肿瘤发生的机制，并探索肿瘤免疫治疗新疗法。相关研究成果发表在Nature、Molecular Cell、 EMBO J.、 PNAS、Cell Reports、J. Leukocyte. Biol.等学术期刊。

学术成果

1. Wanyu Bai,  Guangchao Zhu, Jiejie Xu,  Pingyue Chen,  Feilong Meng, Hongman Xue, Chun Chen# and Junchao Dong#. 3’-flap endonuclease XPF-ERCC1 promotes alternative end joining and chromosomal translocation during B cell class switching. Cell Reports. In press.

2. X Sun, M Liu, J Bai, J Xu, C Zhu, J Dong#, C Chen#.  ATR kinase activity promotes antibody class switch recombination in B cells through cell cycle regulation without suppressing DSB resection and microhomology usage. J. Leukoc Biol. 2021 Apr 22

3. Dingpeng Yang, Ying Sun, Jingjing Chen, Ying Zhang, et al.,  REV7 is required for processing AID initiated DNA lesions in activated B cells. Nature Communications. 2020(1):1-11

4. Xiaojing Liu, Tingting Liu, Yafang Shang, Pengfei Dai, Wubing Zhang, et al., ERCC6L2 promotes DNA orientation-specific recombination in mammalian cells. Cell Research, 2020:1-13

5. Guoxing Zheng, Qingqing Zhu, Junchao Dong, Xin Lin, Chengming Zhu. Rapid generation and selection of Cas9-engineering TRP53 R172P mice that do not have off-target effects. BMC Biotechnology. 2019

6. Juan He, Qiong Yang, Qiang Xiao, Aihua Lei, Xing Li, Pan Zhou, Ting Liu, Lijuan Zhang, Kun Shi, Quan Yang, Junchao Dong, Jie Zhou. IRF-7 Is a Critical Regulator of Type 2 Innate Lymphoid Cells in Allergic Airway Inflammation. Cell reports 2019: 29 (9), 2718-2730 

7. Panchakshari RA, Zhang X, Kumar V, Du Z, Wei PC, Kao J, Dong J#, Alt FW#. DNA double-strand break response factors influence end-joining features of IgH class switch and general translocation junctions. Proc Natl Acad Sci U S A. 2018 Jan 23;115(4):762-767. (*共同通讯作者)

8. Nguyen HV, Dong J, Panchakshari RA, Kumar V, Alt FW, Bories JC. Histone methyltransferase MMSET promotes AID-mediated DNA breaks at the donor switch region during class switch recombination. Proc Natl Acad Sci U S A. 2017 Dec 5;114(49)

9. Hu J, Meyers RM, Dong J, Panchakshari RA, Alt FW, Frock RL. Detecting DNA double-stranded breaks in mammalian genomes by linear amplification-mediated high-throughput genome-wide translocation sequencing. Nat Protoc. 2016 May;11(5):853-71

10.  Dong J#, Panchakshari RA#, Zhang T#, Zhang Y, Hu J, Volpi SA, Meyers RM, Ho YJ, Du Z, Robbiani DF, Meng F, Gostissa M, Nussenzweig MC, Manis JP, Alt FW. Orientation-specific joining of AID-initiated DNA breaks promotes antibody class switching. Nature. 2015 Sep 3;525(7567):134-9 (#co-first author)

11. Gostissa M, Schwer B, Chang A, Dong J, Meyers RM, Marecki GT, Choi VW, Chiarle R, Zarrin AA, Alt FW. gH class switching exploits a general property of two DNA breaks to be joined in cis over long chromosomal distances. Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2644-9

12. Li F#, Dong J#, Eichmiller R, Holland C, Minca E, Prakash R, Sung P, Shim E, Surtees JA, Eun Lee S. Role of Saw1 in Rad1/Rad10 complex assembly at recombination intermediates in budding yeast. EMBO J. 2013 Feb 6;32(3):461-72 (#co-first author)

13. Toh GW#, Sugawara N#, Dong J#, Toth R, Lee SE, Haber JE, Rouse J.Mec1/Tel1-dependent phosphorylation of Slx4 stimulates Rad1/Rad10 dependent cleavage of non-homologous DNA tails. DNA Repair (Amst). 2010 Jun 4;9(6):718-2 (#co-first author)

14. Li F, Dong J#, Pan X, Oum JH, Boeke JD, Lee SE. Microarray- based genetic screen defines SAW1, a gene required for Rad1/Rad10-dependent processing of recombination intermediates.Mol Cell. 2008 May 9;30(3):325-35 (#co-first author)

科研项目

基金项目：
1.广东省引进创新创业团队，团队带头人，iPS细胞源性组织构建及其治疗重大疾病的新技术研发，项目编号：2016ZT06S029，年份：2017-202
2.广东省自然科学基金重点项目，主持，基于iPS细胞乳腺癌模型研究乳腺癌发生发展、耐药及转移的分子机理，项目编号：2021B1515120063，年份：2021-2024
3.国家自然科学基金面上项目，主持，细胞命运决定转录因子通过诱导染色质三维结构的TAD重组调控细胞命运. 项目批准号：32170798，年份：2022-2025
4.国家自然科学基金面上项目，主持，核空间表观结构域调控神经分化的功能和机理. 项目批准号：31970811，年份：2020-2023
5.国家自然科学基金面上项目，主持，DNA结合蛋白Arid3b在干细胞多能性建立及定向分化中的功能与机制研究，项目批准号：31771639，年份：2018-2021

获奖荣誉

2016 入选中山大学第二批
2016 入选国家高层次引进人才青年项目
2017 入选广东省“珠江人才计划”引进创新创业团队
2017 科技部重点研发项目骨干

学术兼职

为以下学术期刊特邀审稿人：

Cancer Letters (影响因子5.62)
Molecular and Cellular Biology (影响因子4.78)
International Journal of Biological Sciences (3.98)
PLOS One(影响因子3.23)
Mutation Research (影响因子3.68)