导师资格：博士生导师

所在教研室/单位： 遗传学与细胞生物学教研室

E-mail：[email protected]

通信地址： 广州市中山二路74号 中山大学北校区博彩公司排名

研究方向：本课题组通过深入研究干细胞的多能性以及体细胞重编程的分子机理，阐明胚胎干细胞的自我更新以及体细胞重编程的发生发展过程，并利用iPS细胞建立肿瘤疾病模型，对于干细胞的临床应用具有重要意义

个人/课题组主页：//rankbc.net/stemcellding/

个人简介

国家杰出青年基金获得者；国家海外高层次青年人才；广东省珠江人才计划创新创业团队带头人。

2002年6月毕业于北京师范大学，获理学学士学位。之后于2005年6月毕业于中国协和医科大学获医学硕士学位。2009年6月毕业于北京生命科学研究所，获理学博士学位。后于2009年9月开始在美国西奈山医学院（Icahn School of Medicine at Mount Sinai, NY, U.S.A.）进行博士后研究至2015年底。研究工作主要集中在胚胎干细胞、体细胞重编程以及早期胚胎发育的表观遗传学调控机制等热门生物医学领域，近年共发表SCI论著30篇（8篇IF>20，20篇IF>10）；其中以通讯或一作（含共同）发表论著15篇（6篇IF>20，9篇IF>10），包括Nature、Cell Stem Cell（两篇）、Cell Research（两篇）、Nature Structural & Molecular Biology等。

丁俊军实验室网站：//rankbc.net/stemcellding/

导师：博士导师

学科专业：干细胞

教育背景：

1998-2002
北京师范大学，生物科学，学士

2002-2005
中国协和医科大学，病原生物学，硕士

2006-2009
北京生命科学研究所，细胞生物学，博士

工作经历：

2005-2006
北京生命科学研究所，
干细胞生物学，研究助理，

2009-2015
西奈山医学院
干细胞生物学，博士后，

2016-现在
博彩公司排名-博彩公司评级
干细胞生物学，教授/博士生导师

 

研究领域

本课题组通过深入研究干细胞的多能性以及体细胞重编程的分子机理，阐明胚胎干细胞的自我更新以及体细胞重编程的发生发展过程，并利用iPS细胞建立肿瘤疾病模型，对于干细胞的基础研究和临床应用具有重要意义。基于此，实验室正在围绕多能干细胞开展以下几个方面研究：

1.  表观遗传与相分离：利用基因编辑和蛋白质组学等手段研究多能干细胞、体细胞重编程以及早期胚胎发育的表观遗传调控机制，包括相分离的调控机制和功能；

2.  三维基因组：结合染色体三维结构技术（HiC、HiChIP等）研究干细胞多能性的三维基因组调控机制；

3.  生物信息学与机器学习：利用生物信息学技术进行表观组学研究，整合二维的基因组学、转录组学、蛋白组学等数据和HiC、HiChIP等染色质三维数据，进行细胞命运和疾病发生的研究；

4.  干细胞疾病模型：利用诱导多能干细胞（iPS细胞）建立人类疾病模型，特别是乳腺癌模型，并利用模型研究其发病机理、早期诊断，长期目标为筛选药物。

学术成果

通讯及第一作者论文（含共同）：

  1. 代表性通讯及第一作者论文（含共同）：
  2. Xiuxiao Tang*, Pengguihang Zeng*, Kezhi Liu, Li Qing, Yifei Sun, Xinyi Liu, Lizi Lu, Chao Wei, Jia Wang, Shaoshuai Jiang, Jun Sun, Wakam Chang, Haopeng Yu, Hebing Chen, Jiaguo Zhou, Chengfang Xu#, Lili Fan#, Yi-Liang Miao#, Junjun Ding# (Corresponding author). The PTM profiling of CTCF reveals the regulation of 3D chromatin structure by O-GlcNAcylation. Nature Communications. 2024 Apr 1;15(1):2813. doi: 10.1038/s41467-024-47048-3. (IF:16.6)
  3. Jun Sun*, Jiale Qu*, Cai Zhao*, Xinyao Zhang, Xinyu Liu, Jia Wang, Chao Wei, Xinyi Liu, Mulan Wang, Pengguihang Zeng, Xiuxiao Tang, Xiaoru Ling, Li Qing, Shaoshuai Jiang, Jiahao Chen, Tara SR Chen, Yalan Kuang, Jinhang Gao, Xiaoxi Zeng, Dongfeng Huang, Yong Yuan#, Lili Fan#, Haopeng Yu#, Junjun Ding# (Corresponding author). Precise prediction of phase-separation key residues by machine learning. Nature Communications. 2024 Mar 26;15(1):2662. doi: 10.1038/s41467-024-46901-9. (IF:16.6)
  4. Jiale Qu*, Jun Sun*, Cai Zhao, Xinyi Liu, Xinyao Zhang, Shaoshuai Jiang, Chao Wei, Haopeng Yu, Xiaoxi Zeng#, Lili Fan#, Junjun Ding# (Corresponding author). Simultaneous profiling of chromatin architecture and transcription in single cells. Nature Structural & Molecular Biology. 2023 Sep;30(9):1393-1402. doi: 10.1038/s41594-023-01066-9.(IF:18.36)
  5. Chao Wei*, Lumeng Jia*, Xiaona Huang*, Jin Tan*, Mulan Wang, Jing Niu, Yingping Hou, Jun Sun, Pengguihang Zeng, Jia Wang, Li Qing, Lin Ma, Xinyi Liu, Xiuxiao Tang, Fenjie Li, Shaoshuai Jiang, Jingxin Liu, Tingting Li, Lili Fan, Yujie Sun, Juntao Gao, Cheng Li, Junjun Ding# (Corresponding author). CTCF organizes inter-A compartment interactions through RYBP-dependent phase separation. Cell Research. 2022 Aug;32(8):744-760. doi: 10.1038/s41422-022-00676-0. (IF:46.297)
  6. Xinyi Liu*, Shaoshuai Jiang*, Lin Ma, Jiale Qu, Longying Zhao, Xing Zhu, Junjun Ding# (Corresponding author). Time-dependent effect of 1,6-hexanediol on biomolecular condensates and 3D chromatin organization. Genome Biology. 2021 Aug 17;22(1):230. doi: 10.1186/s13059-021-02455-3. (IF: 17.906)
  7. Jia Wang, Haopeng Yu, Qian Ma, Pengguihang Zeng, Danya Wu, Yingping Hou, Xinyi Liu, Lumeng Jia, Jun Sun, Yilong Chen, Diana Guallar, Miguel Fidalgo, Jiahao Chen, Yangyinhui Yu, Shaoshuai Jiang, Fenjie Li, Cai Zhao, Xianglin Huang, Jianlong Wang, Cheng Li, Yujie Sun, Xiaoxi Zeng, Wei Zhang, Yiliang Miao, Junjun Ding# (Corresponding author). Phase separation of OCT4 controls TAD reorganization to promote cell fate transitions. Cell Stem Cell. 2021 May 25; doi://doi.org/10.1016/j.stem.2021.04.023. （IF: 25.269）
  8. Xiaona Huang* Chao Wei* Fenjie Li* Lumeng Jia, Pengguihang Zeng, Jiahe Li, Jin Tan, Tuanfeng Sun, Shaoshuai Jiang, Jia Wang, Xiuxiao Tang, Qingquan Zhao, Bin Liu, Limin Rong, Cheng Li, and Junjun Ding# (Corresponding author). PCGF6 regulates stem cell pluripotency as a transcription activator via super-enhancer dependent chromatin interactions. Protein & Cell. 2019 Oct;10(10):709-725. （IF: 15.328）
  9. Li Fenjie, Junjun Ding# (Corresponding author).  Sialylation is involved in cell fate decision during development, reprogramming and cancer progression. Protein & Cell. 2019 Aug;10(8):550-565. Review. （IF: 15.328）
  10. Jia Wang*, Xingui Wu*, Chao Wei*, Xin Huang, Qian Ma, Xiaona Huang, Francesco Faiola, Diana Guallar, Miguel Fidalgo, Tingyuan Huang, Di Peng, Li Chen, Haopeng Yu, Xingyu Li, Junyi Sun, Xinyi Liu, Xiaoxia Cai, Xiao Chen, Ling Wang, Jian Ren, Jianlong Wang#, Junjun Ding# (Corresponding author). YY1 Positively Regulates Transcription by Targeting Promoters and Super-Enhancers through the BAF Complex in Embryonic Stem Cells, Stem Cell Reports. 2018 March 1; doi: 10.1016/j.stemcr.2018.02.004. （IF: 7.294）
  11. Junjun Ding, Xin Huang, Ningyi Shao, Hongwei Zhou, Dung-Fang Lee, Francesco Faiola, Miguel Fidalgo, Diana Guallar, Arven Saunders, Pavel V. Shliaha, Hailong Wang, Avinash Waghray, Dmitri Papatsenko, Carlos Sánchez-Priego, Dan Li, Ye Yuan, Ihor R. Lemischka, Li Shen, Kevin Kelley, Haiteng Deng, Xiaohua Shen, and Jianlong Wang. Tex10 Coordinates Epigenetic Control of Super-Enhancer Activity in Pluripotency and Reprogramming, Cell Stem Cell. 2015 Jun 4;16(6):653-68.（IF: 25.269）
  12. Yael Costa*, Junjun Ding* (co-first author), Thorold W. Theunissen*, Francesco Faiola*, Timothy A. Hore, Pavel V. Shliaha, Miguel Fidalgo, Arven Saunders, Moyra Lawrence, Sabine Dietmann, Satyabrata Das, Dana N. Levasseur, Zhe Li, Mingjiang Xu, Wolf Reik, Jose´ C. R. Silva & Jianlong Wang.  NANOG-dependent function of TET1 and TET2 in establishment of pluripotency, Nature. 2013 Mar 21;495(7441):370-4.（IF: 69.504）
  13. Junjun Ding, Huilei Xu, Francesco Faiola, Avi Ma'ayan, Jianlong Wang. Oct4 links multiple epigenetic pathways to the pluripotency network, Cell Research. 2012 Jan;22(1):155-67（IF: 46.297）
  14. Junjun Ding*, Yuanbiao Guo*, Sheng Liu, Yujuan Yan, Gang Chang, Zhaohui Kou, Yu Zhang, Ying Jiang, Fuchu He, Shaorong Gao and Jianli Sang. ES Cells Derived from Somatic Cloned and Fertilized Blastocysts are Post- transcriptionally Indistinguishable: a MicroRNA and Protein Profiles Comparison, Proteomics. 2009 May; 9(10):2711-21.（IF: 5.393）

其它论文节选

  1. Guang Shi, Yaofu Bai, Xiya Zhang, Junfeng Su, Junjie Pang, Quanyuan He, Pengguihang Zeng, Junjun Ding, Yuanyan Xiong, Jingran Zhang, Jingwen Wang, Dan Liu, Wenbin Ma, Junjiu Huang, Zhou Songyang. Bend family proteins mark chromatin boundaries and synergistically promote early germ cell differentiation. Protein & Cell. 2022 Oct;13(10):721-741. doi: 10.1007/s13238-021-00884-1. (IF:15.328)
  2. Mingsen Li, Huaxing Huang, Bofeng Wang, Shaoshuai Jiang, Huizhen Guo, Liqiong Zhu, Siqi Wu, Jiafeng Liu, Li Wang, Xihong Lan, Wang Zhang, Jin Zhu, Fuxi Li, Jieying Tan, Zhen Mao, Chunqiao Liu, Jianping Ji, Junjun Ding, Kang Zhang, Jin Yuan, Yizhi Liu, Hong Ouyang. Comprehensive 3D epigenomic maps define limbal stem/progenitor cell function and identity. Nature Communications. 2022 Mar 11;13(1):1293. doi: 10.1038/s41467-022-28966-6. (IF:17.694)
  3. Xin Huang, Kyoung-Mi Park, Paul Gontarz, Bo Zhang, Joshua Pan, Zachary McKenzie, Laura A Fischer, Chen Dong, Sabine Dietmann, Xiaoyun Xing, Pavel V Shliaha, Jihong Yang, Dan Li, Junjun Ding, Tenzin Lungjangwa, Maya Mitalipova, Shafqat A Khan, Sumeth Imsoonthornruksa, Nick Jensen, Ting Wang, Cigall Kadoch, Rudolf Jaenisch, Jianlong Wang, Thorold W Theunissen. OCT4 cooperates with distinct ATP-dependent chromatin remodelers in naïve and primed pluripotent states in human. Nature Communications. 2021 Aug 26;12(1):5123. doi: 10.1038/s41467-021-25107-3. (IF:17.694)
  4. Xiang Sun, Zhijun Ren, Yixian Cun, Cai Zhao, Xianglin Huang, Jiajian Zhou, Rong Hu, Xiaoxi Su, Lu Ji, Peng Li, King Lun Kingston Mak, Feng Gao, Yi Yang, He Xu, Junjun Ding, Nan Cao, Shuo Li, Wensheng Zhang, Ping Lan, Hao Sun, Jinkai Wang, Ping Yuan. Hippo-YAP signaling controls lineage differentiation of mouse embryonic stem cells through modulating the formation of super-enhancers. Nucleic acids research. 2020 Jul 27;48(13):7182-7196. doi: 10.1093/nar/gkaa482. (IF:19.160)
  5. Mingsen Li, Huaxing Huang, Lingyu Li, Chenxi He, Liqiong Zhu, Huizhen Guo, Li Wang, Jiafeng Liu, Siqi Wu, Jingxin Liu, Tao Xu, Zhen Mao, Nan Cao, Kang Zhang, Fei Lan, Junjun Ding, Jin Yuan, Yizhi Liu, Hong Ouyang. Core transcription regulatory circuitry orchestrates corneal epithelial homeostasis. Nature Communicaitons. 2021 Jan 18;12(1):420. doi: 10.1038/s41467-020-20713-z.（IF: 17.694）
  6. Fuxi Li, Yang Yi, Yanyan Miao, Wenyong Long, Teng Long, Siyun Chen, Weisheng Cheng, Changye Zou, Yueyuan Zheng, Xingui Wu, Junjun Ding, Kaiyu Zhu, Delin Chen, Qiongcong Xu, Jinkai Wang, Qing Liu, Feng Zhi, Jian Ren, Qi Cao and Wei Zhao. N6-Methyladenosine Modulates Nonsense-Mediated mRNA Decay in Human Glioblastoma. Cancer Research. 2019 Nov 15;79(22):5785-5798. （IF: 13.312）
  7. Kun-Yong Kim, Yoshiaki Tanaka, Juan Su, Bilal Cakir, Yangfei Xiang, Benjamin Patterson, Junjun Ding, Yong-Wook Jung, Ji-Hyun Kim, Eriona Hysolli, Haelim Lee, Rana Dajani, Jonghwan Kim, Mei Zhong, Jeong-Heon Lee, David Skalnik, Jeong Mook Lim, Gareth J. Sullivan, Jianlong Wang & In-Hyun Park. Uhrf1 regulates active transcriptional marks at bivalent domains in pluripotent stem cells through Setd1a, Nature Communicaitons. 2018 Jul 3;9(1):2583. doi: 10.1038/s41467-018-04818-0. （IF: 17.694）
  8. Songyan Han, Christopher Tan, Junjun Ding, Jianlong Wang, Avi Ma'ayan, Valerie Gouon-Evans. Endothelial cells instruct liver specification of embryonic stem cell-derived endoderm through endothelial VEGFR2 signaling and endoderm epigenetic modifications, Stem Cell Research. 2018 Jul;30:163-170. doi: 10.1016/j.scr.2018.06.004. （IF: 1.587）
  9. Diana Guallar, Xianju Bi, Jose Angel Pardavila, Xin Huang, Carmen Saenz, Xianle Shi, Hongwei Zhou, Francesco Faiola, Junjun Ding, Phensinee Haruehanroengra, Fan Yang, Dan Li, Carlos Sanchez-Priego, Arven Saunders, Feng Pan, Victor Julian Valdes, Kevin Kelley, Miguel G. Blanco, Lingyi Chen, Huayan Wang, Jia Sheng, Mingjiang Xu, Miguel Fidalgo, Xiaohua Shen & Jianlong Wang. RNA-dependent chromatin targeting of TET2 for endogenous retrovirus control in pluripotent stem cells, Nature Genetics. 2018 Feb 26. doi: 10.1038/s41588-018-0060-9. （IF: 41.307）
  10. Chunliu Huang  Junjie Shi  Yibin Guo  Weijun Huang  Shanshan Huang Siqi Ming  Xingui Wu  Rui Zhang  Junjun Ding  Wei Zhao  Jie Jia  Xi Huang Andy Peng Xiang  Yongsheng Shi  Chengguo Yao. A snoRNA modulates mRNA 3' end processing and regulates the expression of a subset of mRNAs, Nucleic Acids Research. 2017 Sep 6;45(15):8647-8660.  （IF: 19.160）
  11. Francesco Faiola, Nuoya Yin, Miguel Fidalgo, Xin Huang, Arven Saunders, Junjun Ding, DianaGuallar, BaoyenDang, JianlongWang. NAC1 Regulates Somatic Cell Reprogramming by Controlling Zeb1 and E-cadherin Expression, Stem Cell Reports. 2017 Sep 12;9(3):913-926. （IF: 7.294）
  12. Arven Saunders, Dan Li, Francesco Faiola, Xin Huang, Miguel Fidalgo, Diana Guallar, Junjun Ding, Fan Yang, Yang Xu, Hongwei Zhou, Jianlong Wang. Context-Dependent Functions of NANOG Phosphorylation in Pluripotency and Reprogramming, Stem Cell Reports. 2017 May 9;8(5):1115-1123. （IF: 7.294）
  13. Bo Yang, Yi Qiu, Niu Zhou, Hong Ouyang, Junjun Ding, Bin Cheng, Jianbo Sun. Application of Stem Cells in Oral Disease Therapy: Progresses and Perspectives. Frontiers in Physiology. 2017 Apr 3;8:197. Review. （IF: 4.755）
  14. Arven Saunders, Xin Huang, Miguel Fidalgo, Michael H. Reimer Jr., Francesco Faiola, Junjun Ding, Carlos Sánchez-Priego, Diana Guallar, Carmen Sáenz, Dan Li, Jianlong Wang. The SIN3A/HDAC Corepressor Complex Functionally Cooperates with NANOG to Promote Pluripotency, Cell Reports. 2017 Feb 14;18(7):1713-1726. （IF: 9.995）
  15. Miguel Fidalgo, Xin Huang, Diana Guallar, Carlos Sanchez-Priego, Victor Julian Valdes, Arven Saunders, Junjun Ding, Wen-Shu Wu, Carlos Clave, Jianlong Wang. Zfp281 Coordinates Opposing Functions of Tet1 and Tet2 in Pluripotent States, Cell Stem Cell. 2016 Jun 21. （IF: 25.269）
  16. Jiao Yang, Renpeng Guo, Hua Wang, Xiaoying Ye, Zhongcheng Zhou, Jiameng Dan, Haiying Wang, Peng Gong, Wei Deng, Yu Yin, ShiQing Mao, Lingbo Wang, Junjun Ding, Jinsong Li, David L. Keefe, Meelad M. Dawlaty, Jianlong Wang, GuoLiang Xu, Lin Liu. Tet Enzymes Regulate Telomere Maintenance and Chromosomal Stability of Mouse ESCs, Cell Reports. 2016 May 24;15(8):1809-21. （IF: 9.995）
  17. Miguel Fidalgo, Francesco Faiola, Carlos-Filipe Pereira, Junjun Ding, Arven Saunders, Julian Gingold, Christoph Schaniel, Ihor R. Lemischka, José C. R. Silva, and Jianlong Wang. Zfp281 mediates Nanog   autorepression through recruitment of the NuRD complex and inhibits somatic cell reprogramming, Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):16202-7. （IF: 12.779）
  18. Yen-Sin Ang, Su-Yi Tsai, Dung-Fang Lee, Jonathan Monk, Jie Su, Kajan Ratnakumar, Junjun Ding, Yongchao Ge, Henia Darr, Betty Chang, Jianlong Wang, Michael Rendl, Emily Bernstein, Christoph Schaniel and Ihor R. Lemischkar. Wdr5 Mediates Self-Renewal and Reprogramming via the Embryonic Stem Cell Core Transcriptional Network, Cell. 2011, Volume 145, Issue 2, 15 April 2011, Pages 183-197. （IF: 66.850）

获奖荣誉

  1. 2024年 国家杰出青年基金
  2. 2017年 广东省“珠江人才计划”引进创新创业团队（带头人）
  3. 2017年 干细胞年会青年论坛一等奖（仅一名）
  4. 2016年 中组部国家海外高层次人才计划（青年项目）
  5. 2015年 中山大学百人计划

基金项目

  1. 国家杰出青年科学基金，主持，多能干细胞的染色质三维结构调控, 项目批准号：32425022，年份：2025-2029
  2. 广东省引进创新创业团队，团队带头人，iPS细胞源性组织构建及其治疗重大疾病的新技术研发，项目编号：2016ZT06S029，年份：2017-2022
  3. 广东省自然科学基金重点项目，主持，基于iPS细胞乳腺癌模型研究乳腺癌发生发展、耐药及转移的分子机理，项目编号：2021B1515120063，年份：2021-2024
  4. 国家自然科学基金面上项目，主持，细胞命运决定转录因子通过诱导染色质三维结构的TAD重组调控细胞命运. 项目批准号：32170798，年份：2022-2025
  5. 国家自然科学基金面上项目，主持，核空间表观结构域调控神经分化的功能和机理. 项目批准号：31970811，年份：2020-2023 
  6. 国家自然科学基金面上项目，主持，DNA结合蛋白Arid3b在干细胞多能性建立及定向分化中的功能与机制研究，项目批准号：31771639，年份：2018-2021

其他

本实验室博士后科研人员。

要求（符合任何一项者均可申请）：

  1. 生物信息研究背景者 （可适当增加每月补助）；
  2. 有表观遗传研究背景者；
  3. 有干细胞或者肿瘤研究背景者；

岗位待遇

  1. 年薪不低于26万（包括五险二金）。
  2. 协助申报逸仙博士后项目，年薪不低于50万（包括五险二金）。于境外获得博士学位并符合条件者，可申请“广东省博士后人才引进计划”以及其他博士后人才项目，最高可获100万资助。
  3. 在站期间，提供博士后公寓，子女可申请入读中山大学附属中小学和幼儿园。
  4. 全力支持博士后申请各种基金和人才项目，优秀者可申请应聘本校事业编制的教研岗教师系列。

也欢迎报考我的硕士以及博士研究生。