博彩公司排名

个人简介

黄朝峰,博士，博彩公司排名-博彩公司评级 副教授，博士生导师。2003年毕业于中国科学院遗传与发育生物学研究所，获遗传学博士学位。2004年美国伊利诺大学医学院微生物与免疫系做博士后；2009年起在美国农业部Jean Mayer 营养老化研究所营养免疫实验室担任助理研究员；2010年3月中山大学引进。主要研究方向：1. Th17细胞分化及功能活性调节的机制和临床应用。2. 免疫细胞治疗技术抗肿瘤和自免疫性疾病的临床应用探索。近年累积在《Nature immunology》 《Journal of Immunology》等专业杂志上发表论文30多篇，申请并授权发明专利10余项，申请PCT国际专利1项并进入多个国家和地区。主持包括国家自然基金面上项目和广东省科技计划、广州市对外科技合作专项等多项国家自然基金和省市重大科研项目，累计获得资助400多万元。

学术成果

学术论著与教材：

1. Yang Y, Deng Y, Zhang G, Xu X, Xiong X, Yu S, Peng F, Tian X, Ye W, Chen H, Yu B, Liu Z, He X, Huang Z.a-mangostin derivatives ameliorated mouse DSS-induced chronic colitis via regulating Th17/Treg balance. Mol Immunol. 2024 Feb;166:110-118. doi: 10.1016/j.molimm.2023.11.013
2. Chen H, Yang Y, Deng Y, Wei F, Zhao Q, Liu Y, Liu Z, Yu B, Huang Z. Delivery of CD47 blocker SIRPα-Fc by CAR-T cells enhances antitumor efficacy. Journal for immunotherapy of cancer. 2022;10(2). (IF: 13.751)
3. Huanpeng Chen, Fengjiao Wei, Meng Yin, Qingyu Zhao, Zhonghua Liu, Bolan Yu ，Zhaofeng Huang*. CD27 enhances the killing effect of CAR T cells targeting trophoblast cell surface antigen 2 in the treatment of solid tumors. Cancer Immunol Immunother 2021 Jul;70(7):2059-2071..
4. Xuyan Tian, Lipeng Tang, Fengjiao Wei, Huanpeng Chen, Longxiang Sheng, Yuying Yang, Xiaoqing Zhou, Yongchao Li, Xiaoting Xu, Boyang Zhang, Zhonghua Liu, Yu Lei, Bolan Yu, Chuan Bai, Xixin He*, Zhaofeng Huang*. Pentacyclic triterpene compounds from loquat leaves reduce skin inflammation and epidermal hyperplasia in psoriasis via inhibiting the Th17 cells [J]. Mol Immunol. 2021 Apr;132:30-40..
5. Wei F, Zhou X, Chen H, Tian X, Liu Z, Yu B, He X, Bai C*, Huang Z*. 5,6,7,8- Tetrahydrobenzo [4,5]thieno[2,3-d]pyrimidine derivative attenuates lupus nephritis with less effect to thymocyte development. Immunol Res. 2021 Aug;69(4):378-390. 
6. Zhou X, Chen H, Wei F, Zhao Q, Su Q, Lei Y, Yin M, Tian X, Liu Z, Yu B, Bai C, He X*, Huang Z*. α-mangostin attenuates pristane-induced lupus nephritis by regulating Th17 differentiation. Int J Rheum Dis. 2020 Jan;23(1):74-83. doi: 10.1111/1756-185X.13743.
7. Zhou X, Chen H, Wei F, Zhao Q, Su Q, Lei Y, Yin M, Tian X, Liu Z, Yu B, Bai C, He X*, Huang Z*. The Inhibitory Effects of Pentacyclic Triterpenes from Loquat Leaf against Th17 Differentiation. Immunol Invest. 2020 Aug;49(6):632-647. doi: 10.1080/08820139. 2019. 1698599.  
8. Zhou X, Chen H, Wei F, Zhao Q, Su Q, Liang J, Yin M, Tian X, Liu Z, Yu B, Bai C, He X*, Huang Z*. 3β-Acetyloxy-oleanolic Acid Attenuates Pristane-Induced Lupus Nephritis by Regulating Th17 Differentiation. J Immunol Res. 2019 May 22;2019:2431617. doi: 10.1155/2019/2431617.
9. Lao C, Zhou X, Chen H, Wei F, Huang Z*, Bai C* 5,6,7,8-Tetrahydrobenzo [4,5]thieno[2,3-d]pyrimidine derivatives as inhibitors of full-length RORγt. Bioorg Chem. 2019, 90:103077. doi: 10.1016/j.bioorg. 2019. 103077. 
10. Wu X, Huang J, Dai L, Zhou J, Huang Z, Yu B*  Adolescent diabetes induced by multiple parental exposures to cigarette smoke condensate. Toxicol Lett. 2019 Oct 10;314:98-105. doi: 10.1016/j.toxlet.2019.07.012.
11. Wu K, Li Y, Zhang S, Zhou N, Liu B, Pan T, Zhang X, Luo H, Huang Z, Li X, Zhang H, Zhang J*. Preferential Homing of Tumor-specific and Functional CD8+ Stem Cell-like Memory T Cells to the Bone Marrow. J Immunother. 2019, 42(6):197-207. doi: 10.1097/CJI.0000000000000273.
12. Wu K, Zhang S, Zhang X, Li X, Hong Z, Yu F, Liu B, Pan T, Huang Z, Tang XP, Cai W, Xia J, Li X, Zhang H, Zhang Y*, Li L*. IL-21 Expands HIV-1-Specific CD8+ T Memory Stem Cells to Suppress HIV-1 Replication In Vitro. J Immunol Res. 2019, 2019:1801560. doi: 10.1155/2019/1801560. 
13. Sheng L, Lu B, Chen H, Du Y, Chen C, Cai W, Yang Y, Tian X, Huang Z, Chi W, Lin S, Yan G, Yin W. Marine-Steroid Derivative 5α-Androst-3β, 5α, 6β-triol Protects Retinal Ganglion Cells from Ischemia⁻Reperfusion Injury by Activating Nrf2 Pathway. Mar Drugs. 2019,17(5). pii: E267. doi: 10.3390/md1705026.
14. Zhao G, Mo J, Zheng T, Li Y, Wu X, Huang J, Liu G, Huang Z*, Yu B*. Puberty exposure to cigarette smoke extract impairs adult spermatogenesis in the mouse. Reprod Toxicol. 2019,83:8-13. doi: 10.1016/j.reprotox.2018.10.012.
15. Zhiheng He ; Zhang J; Huang Z; Du Q; Li N; Zhang Q; Chen Y; Sun Z * Sumoylation of RORγt regulates TH17 differentiation and thymocyte development., Nat Commun, 2018, 9(1) p.4870
16. Zhao, C.-L., Xia, Y.-X., Ye, J.-H., Ku, C.F., Li, W.-F., Luo, G.-Y., Zhang, J.-J., Xu, J., Huang, ZF., Tsang, S.W. et al. (2018). Isolation, evaluation of bioactivity and structure determination of amethinol A, a prototypic amethane diterpene from Isodon amethystoides bearing a six/five/seven-membered carbon-ring system.Acta Crystallogr C Struct Chem. 2018 , 74(Pt 5):635-640. doi: 10.1107/S2053229618005740. 
17. He Z#, Ma J#, Wang F, Wang R, Huang Z, Zhang J, Sen S, Rothenberg E,  Sun Z* Two amino acid mutation disrupts RORgt function in Th17 differentiation but not thymocyte development . Nature Immunology 2017, 18(10): 1128-1138.  doi: 10.1038/ni.3832.
18. Xu X, Huang J, Zhao M, Chen H, Mo J, Zhou X, Su Q, Yu B and Huang Z*. Stabilized ß-catenin ameliorates ALPS-like symptoms of B6/lpr mice. Journal of Immunology research. 2017, Article ID 3469108. doi.org/10.1155/2017/ 3469108 .
19. Xu X, Yu B, Cai W, Huang Z*. TCF1 deficiency ameliorates autoimmune lymphoproliferative syndrome (ALPS)-like phenotypes of lpr/lpr mice. Scand J Immunol. 2017，85：406-416.  doi: 10.1111/sji.12546. 
20. Zhao M, Chen H, Ding Q, Xu X, Yu B, Huang Z*. Nuclear Factor Erythroid 2-related Factor 2 Deficiency Exacerbates Lupus Nephritis in B6/lpr mice by Regulating Th17 Cell Function. Sci Rep. 2016, 6:38619. doi: 10.1038/srep38619
21. Yu B, Huang Z*. Variations in Antioxidant Genes and Male Infertility.Biomed Res Int. 2015:513196. doi: 10.1155/2015/513196.
22. Yu B, Zhou H, Liu M, Zheng T, Jiang L, Zhao M, Xu X, Huang Z*. Epigenetic Alterations in Density Selected Human Spermatozoa for Assisted Reproduction. PLoS One. 10(12):e0145585. doi: 10.1371/journal.pone.0145585. 
23. Ding Q, Zhao M, Yu B, Bai C, Huang Z*. Identification of tetraazacyclic compounds as novel potent inhibitors antagonizing RORγt activity and suppressing Th17 cell differentiation. plos one 2015 , 10(9):e0137711 DOI: 10.1371/journal.pone.0137711
24. Ding Q, Zhao M, Bai C, Yu B, Huang Z*. Inhibition of RORγt activity and Th17 differenti ation by a set of novel compounds. BMC immunology 2015, 16:32. DOI: 10.1186/s12865-015-0097-9
25. Yu B , Ding Q, Zheng T, Jiang L, Li Q, Sun X, Bai C and Z. Huang*. Smoking attenuated the association between IκBα rs696 polymorphism and defective spermatogenesis in humans. ANDROLOGIA 2015,47(9): 987–994 DOI: 10.1111/and.12368
26. Yu B, Qi Y, Liu D, Gao X, Chen H, Bai C, Huang Z*. Cigarette smoking is associated with abnormal histone-to-protamine transition in human sperm. Fertil Steril. 2014, 101(1):51-57.
27. Chen J, Yang L, Huang Z*. The N-terminal 33 amino acid sequence  of Siva-1 is
    sufficient for nuclear localization. Brazilian Journal of Medical and Biological Research 2013, 46(12): 1021-1027. 
28. Yu B, Chen J, Liu D, Zhou H, Xiao W, Xia X, Huang Z*. Cigarette smoking is associated with human semen quality in synergy with functional NRF2 polymorphisms. Biol Reprod. 2013, 89(1):5.
29. Yu B, Mai Z, Liu X, Huang Z*. Selective estrogen receptor modulator BC-1 activates antioxidant signaling pathway in vitro via formation of reactive metabolites. Acta Pharmacol Sin. 34(3):373-9. 2013
30. Molano A, Huang Z, Marko MG, Azzi A, Wu D, Wang E, Kelly SL, Merrill AH Jr, Bunnell SC, Meydani SN.  PLoS One. 2012;7(10):e47650. doi: 10.1371/journal.pone.0047650.
31. Yu B, Lin H, Yang L, Chen K, Luo H, Liu J, Gao X, Xia X, Huang Z*. Genetic variation in the Nrf2 promoter associates with defective spermatogenesis in humans. J Mol Med (Berl). 2012, 90(11):1333-42. 

科研项目

主持项目：       

国家自然基金委面上项目：b-Catenin调节T细胞激活后凋亡的分子机制。31170831 2012.1-2015.12  60万

广东省科技厅公益建设和能力项目建设专项：环境氧化应激和NRF2基因缺陷协同诱导早发型系统性红斑狼疮模型。2015A030302016  2015.7.1-2017.12.31   10万

广东省粤港联合创新项目：基于岭南药用植物中寻找RORγt天然小分子抑制剂及其在狼疮性肾炎治疗中的应用。2016A050503023 2016.1.1-2018.12.31  100万

广东省国际合作专项：新型Th17细胞分化抑制剂的靶标特异性评价体系的建立。2017A050501010 2017.1.1-2019.12.31   50万

广东省自然基金面上项目：山竹活性物质抑制RORγt活性与Th17细胞功能的分子机制。2021A1515010339   2021.1-2023.12。 负责人，结题，广东省科技厅

广东省自然基金面上项目：四氮杂环噻吩并嘧啶靶向调节RORγt活性的作用机制及在自免疫疾病治疗中的应用。2022A1515011758  2022.1-2024.12。负责人，在研，广东省科技厅。

参与人才项目：

广东省珠江人才计划引进科研创新团队 “重大人类致病病毒特异性药物的研发与免疫细胞的再生工程”项目，核心成员及第三子课题负责人。2009010058   2010.6-2017.12    总计 8000万， 子课题负责 100万

学术兼职

广东省精准医学应用学会理事，疾病模型分会主委，免疫治疗分会副主委。