个人简介

杨明珠博士,博彩公司排名-博彩公司评级 副教授,硕士生导师。2021年博士毕业于博彩公司排名-博彩公司评级 ,导师王继厂教授;2021-2024年在中山大学肿瘤防治中心开展博士后研究工作。主要从事干细胞与异种嵌合研究,部分研究成果已发表于Cell Stem Cell 、Genome Biology、Cell Reports、Nucleic Acids Research等国际权威学术期刊。先后获得国家自然科学青年基金、博士后面上项目等资助。

主要研究领域

  1. 大型哺乳动物的新型多能干细胞研究:解析大型哺乳动物早期胚胎过程中的干细胞多能性调控机制,开发优化的干细胞培养体系,建立非人灵长类、猪等大型哺乳动物的新型多能干细胞系。
  2. 异种嵌合研究:利用非人灵长类、猪等大动物多能干细胞,结合类胚胎等体外模型,研究哺乳动物异种嵌合的关键障碍因素及其调控机制,开发和优化高效的非人灵长类-猪等大动物异种嵌合体技术,以实现在大动物体内培育出功能完善的器官,为人类器官的异种再造提供技术支持。

代表性学术成果

(# co-first author,* co-corresponding author)

  1. Mingzhu Yang#, Hanwen Yu#, Xiu Yu#, Shiqi Liang#, Yuanlang Hu, Yuxin Luo, Zsuzsanna Izsvák, Chuanbo Sun*, Jichang Wang*. Chemical-induced chromatin remodeling reprograms mouse ESCs to totipotent-like stem cells.Cell Stem Cell. 2022; 29:400-418.
  2. Niannian Li# , Kairang Jin# , Bin Liu# , Mingzhu Yang# , PanPan Shi , Dai Heng , Jichang Wang* , Lin Liu* . Single-cell 3D genome structure reveals distinct human pluripotent states. Genome Biol. 2024 May 13;25(1):122.
  3. Xiu Yu#; Shiqi Liang#; Manqi Chen#; Yu Hanwen; Ruiqi Li; Yuliang Qu; Xuhui Kong; Ruirui Guo; Rongyan Zheng; Zsuzsanna Izsvák; Chuanbo Sun*; Mingzhu Yang#*; Jichang Wang*; Recapitulating early human development with 8C-like cells, Cell Reports, 2022, 39(12): 110994-110994.
  4. Jia-Li Hu#, He Liang#, Hong Zhang#, Mingzhu Yang#, Wei Sun, Peng Zhang, Li Luo, Jian-Xiong Feng, Huajun Bai, Fang Liu, Tianpeng Zhang, Jin-Yu Yang, Qingsong Gao, Yongkang Long, Xiao-Yan Ma, Yang Chen, Qian Zhong, Bing Yu, Shuang Liao, Yongbo Wang, Yong Zhao, Mu-Sheng Zeng, Nan Cao, Jichang Wang, Wei Chen*, Huang-Tian Yang*, Song Gao*. FAM46B is a prokaryotic-like cytoplasmic poly(A) polymerase essential in human embryonic stem cells. Nucleic Acids Res. 2020; 48(5):2733-2748.
  5. Liang S, Yu X, Zhou C, Wang J, Yang M*, Sun C. Protocol for deriving human preimplantation epiblast stem cells and 8-cell embryo-like cells. STAR Protoc. 2024 Nov 15;5(4):103446.
  6. Chuanbo, Sun#.; Mingzhu, Yang#; Fengying, Qin.; Ruirui, Guo.; Shiqi, Liang.; Hao, Hu*.; Generation of an induced pluripotent stem cell line SYSUi-003-A from a child with epilepsy carrying GRIN2A mutation, Stem Cell Res, 2020, 43: 101706.
  7. Yu H#, Chen M#, Hu Y#, Ou S#, Yu X, Liang S, Li N, Yang M, Kong X, Sun C, Jia S, Zhang Q, Liu L, Hurst LD, Li R*, Wang W*, Wang J*. Dynamic reprogramming of H3K9me3 at hominoid-specific retrotransposons during human preimplantation development. Cell Stem Cell. 2022 Jul 7;29(7):1031-1050.e12.