导师资格：硕士生导师

所在教研室/单位： 寄生虫学教研室

E-mail：[email protected]

研究方向：宿主抗寄生虫感染免疫及肝脏在感染后损伤和修复的机制研究。目前主要发现包括：1）首次发现宿主免疫细胞可利用“胞啃作用(trogocytosis)”杀伤血吸虫的免疫现象，并阐明了其机制；2）首次明确iNOS是大鼠天然抗血吸虫感染的关键免疫因子及其机制。

个人简介

沈佳，博彩公司排名-博彩公司评级 副教授，硕士生导师。本科毕业于南方医科大学，硕士毕业于博彩公司排名-博彩公司评级 病原生物学专业，于2017年获中山大学生命科学学院微生物学博士学位。2017年至2023年在博彩公司排名-博彩公司评级 从事博士后和专职科研工作，并获得2018年中山大学优秀博士后称号。2024年起担任中山大学副教授职务。

学术成果

代表性学术论著:

  1. Siyu Zhao#, Yunyi Hu, Bicheng Yang, Lichao Zhang, Meiyining Xu, Kefeng Jiang, Zhun Liu, Mingrou Wu, Yun Huang, Peipei Li, Si-Jia Liang, Xi Sun, Geoff Hide, Zhao-Rong Lun, Zhongdao Wu, Jia Shen*. The transplant rejection response involves neutrophil and macrophage adhesion-mediated trogocytosis and is regulated by NFATc3. Cell Death & Disease, 2024,15(1):75.
  2. Mei Peng#, Siyu Zhao, Yunyi Hu, Lichao Zhang, Tao Zhou, Mingrou Wu, Meiyining Xu, Kefeng Jiang, Yun Huang, Dinghao Li, Zhao-Rong Lun, Zhongdao Wu, Jia Shen*. Nitric oxide-induced endoplasmic reticulum stress of Schistosoma japonicum inhibits the worm development in rats. Free Radical Biology and Medicine, 2024, 212:295-308.
  3. Jia Shen#*, Siyu Zhao, Mei Peng, Yanguo Li, Lichao Zhang, Xiaoping Li, Yunyi Hu, Mingrou Wu, Suoyu Xiang, Xiaoying Wu, Jiahua Liu, Beibei Zhang, Zebin Chen, Datao Lin, Huanyao Liu, Wenyan Tang, Jun Chen, Xi Sun, Qi Liao, Geoff Hide, Zhijun Zhou*, Zhao-Rong Lun*, Zhongdao Wu*. Macrophage-mediated trogocytosis contributes to destroying human schistosomes in a non-susceptible rodent host, Microtus fortis. Cell Discovery, 2023, 9(1):101.
  4. Jia Shen#, Si-Fei Yu, Mei Peng, De-Hua Lai, Geoff Hide, Zhongdao Wu*, Zhao-Rong Lun*. iNOS is essential to maintain a protective Th1/Th2 response and the production of cytokines/chemokines against Schistosoma japonicum infection in rats. PLoS Neglected Tropical Diseases, 2022, 18;16(5):e0010403.
  5. Siyu Zhao#, Lichao Zhang, Suoyu Xiang, Yunyi Hu, Zhongdao Wu*, Jia Shen*. Gnawing Between Cells and Cells in the Immune System: Friend or Foe? A Review of Trogocytosis. Frontiers in Immunology, 2022/02, 13: 0-791006.
  6. Mei Peng#, Fang Chen, Zhongdao Wu, Jia Shen*. Endoplasmic Reticulum Stress, a Target for Drug Design and Drug Resistance in Parasitosis. Frontiers in Microbiology, 2021, 12: 670874.
  7. Jia Shen#, Suoyu Xiang#, Mei Peng, Zhijun Zhou*, Zhongdao Wu*. Mechanisms of resistance to Schistosoma japonicum infection in Microtus fortis, the natural non-permissive host. Frontiers in Microbiology, 2020, 11:2092.
  8. Jia Shen#, Lifu Wang#, Mei Peng, Zhen Liu, Beibei Zhang, Tao Zhou, Xi Sun*, Zhongdao Wu*. Recombinant Sj16 protein with novel activity alleviates hepatic granulomatous inflammation and fibrosis induced by Schistosoma japonicum associated with M2 macrophages in a mouse model. Parasites & Vectors, 2019，12(1):457.
  9. Jia Shen#, De-Hua Lai#, R Alan Wilson, Yun-Fu Chen, Li-Fu Wang, Zi-Long Yu, Mei-Yu Li, Ping He, Geoff Hide, Xi Sun, Ting-Bao Yang, Zhong-Dao Wu*, Francisco J Ayala*, Zhao-Rong Lun*. Nitric oxide blocks the development of the human parasite Schistosoma japonicum. PNAS. 2017.114(38):10214-10219.

获奖荣誉

先后主持国家自然科学基金、广东省自然科学基金及中国博士后基金等7项科研项目，作为课题骨干参与国家重点研发项目、973项目等。以第一作者/通讯作者在Cell Discovery、PNAS、Cell Death & Disease、Free Radical Biology and Medicine、PLOS Neglected Tropical Diseases、Parasites & Vectors等国际期刊发表SCI论文10余篇。